(S)-(+)-Ibuprofen

Pricing Availability Delivery Time Qty
Cat.No. 2796 - (S)-(+)-Ibuprofen | C13H18O2 | CAS No. 51146-56-6
Description: Cyclooxygenase inhibitor (COX-1 > COX-2)
Chemical Name: (S)-α-Methyl-4-(2-methylpropyl)benzeneacetic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase 1 and cyclooxygenase 2 (IC50 values are 12 and 80 μM respectively). Active isomer of ibuprofen.

Compound Libraries

(S)-(+)-Ibuprofen is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 206.28
Formula C13H18O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 51146-56-6
PubChem ID 39912
InChI Key HEFNNWSXXWATRW-JTQLQIEISA-N
Smiles CC(C)CC1=CC=C([C@H](C)C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.63 100
ethanol 20.63 100

Preparing Stock Solutions

The following data is based on the product molecular weight 206.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.85 mL 24.24 mL 48.48 mL
5 mM 0.97 mL 4.85 mL 9.7 mL
10 mM 0.48 mL 2.42 mL 4.85 mL
50 mM 0.1 mL 0.48 mL 0.97 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kato et al (2001) Cyclooxygenase-1 and cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs: investigation using human peripheral monocytes. J.Pharm.Pharmacol. 53 1679 PMID: 11804398


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Keywords: (S)-(+)-Ibuprofen, supplier, Cyclooxygenase, inhibitors, inhibits, COX-1, COX-2, Oxygenases, Oxidases, Cyclooxygenase, Tocris Bioscience

Citations for (S)-(+)-Ibuprofen

Citations are publications that use Tocris products.

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Literature in this Area

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Pathways for (S)-(+)-Ibuprofen

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