(S)-CPW 399

Discontinued Product

(S)-CPW 399 (Cat. No. 1543) has been withdrawn from sale for commercial reasons.
Description: Subtype-selective weakly desensitizing AMPA agonist
Chemical Name: (S)-α-Amino-2,3,4,5,6,7-hexahydro-2,4-dioxo-1H-cyclopentapyrimidine-1-propanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity for (S)-CPW 399

Novel subtype-selective and weakly desensitizing AMPA receptor partial agonist (Ki values are 44, 109, 223, 1890 and 2090 nM at GluK1, GluA1, GluA2, GluA3 and GluA4 receptors respectively). Exhibits potent agonist activity at GluA1 and GluA2 subunit-containing AMPA receptors (EC50 values are 24.9 and 13.9 μM respectively) and is excitotoxic in vitro.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data for (S)-CPW 399

M. Wt 239.23
Formula C10H13N3O4
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 389888-02-2
PubChem ID 657004
InChI Key VSGUEKZRMJVQOH-LURJTMIESA-N
Smiles O=C1NC(C2=C(CCC2)N1C[C@H](N)C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for (S)-CPW 399

Certificate of Analysis / Product Datasheet
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Keywords: (S)-CPW 399, (S)-CPW 399 supplier, Subtype-selective, weakly, desensitizing, AMPA, agonists, Glutamate, Receptors, iGlur, Ionotropic, (S)-CPW399, 1543, Tocris Bioscience

Citations for (S)-CPW 399

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