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Novel subtype-selective and weakly desensitizing AMPA receptor partial agonist (Ki values are 44, 109, 223, 1890 and 2090 nM at GluK1, GluA1, GluA2, GluA3 and GluA4 receptors respectively). Exhibits potent agonist activity at GluA1 and GluA2 subunit-containing AMPA receptors (EC50 values are 24.9 and 13.9 μM respectively) and is excitotoxic in vitro.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
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References are publications that support the biological activity of the product.
Butini et al (2008) 1H-Cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptor ligands. Structure-activity relationships and identification of potent and selective iGluR5 modulators. J.Med.Chem. 51 6614 PMID: 18811139
Campiani et al (2001) Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent and subtype-selective AMPA receptor full agonist with partial desensitization properties. J.Med.Chem. 44 4501 PMID: 11741469
Sinclair et al (2003) Inherent desensitisation-preventing properties of a novel subtype-selective AMPA receptor agonist, (S)-CPW 399, as a possible explanation for its excitotoxic action in cultured cerebellar granule cells. Neurochem.Int. 42 499 PMID: 12547649
Keywords: (S)-CPW 399, (S)-CPW 399 supplier, Subtype-selective, weakly, desensitizing, AMPA, agonists, Glutamate, Receptors, iGlur, Ionotropic, (S)-CPW399, 1543, Tocris Bioscience
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