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Potent AMPA receptor agonist. Also active at dorsal root C fibre kainate receptors and DRG cells.
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Hawkins et al (1995) Binding of the new radioligand (S)-[3H]-AMPA to rat synaptic membranes: effects of a series of structural analogues of the non-NMDA receptor agonist willardine. Neuropharmacology 34 405 PMID: 7566471
Patneau et al (1992) Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine. J.Neurosci. 12 595 PMID: 1371315
Jane et al (1991) New willardiine analogues with potent stereoselective actions of mammalian spinal neurones. Br.J.Pharmacol. 104 333P
Thompson et al (1996) Depolarising effects of certain derivatives of (S)-willardine upon in vitro neonatalrat dorsal roots. Br.J.Pharmacol. 117 331P
Keywords: (S)-5-Bromowillardiine, (S)-5-Bromowillardiine supplier, AMPA, Receptors, 0304, Tocris Bioscience
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
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