S 24795

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Cat.No. 3518 - S 24795 | C14H13BrINO | CAS No. 304679-75-2
Description: Partial agonist at α7 nAChR
Chemical Name: 2-[2-(4-Bromophenyl)-2-oxoethyl]-1-methylpyridinium iodide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Partial agonist of α7 nAChR. Improves mnemonic function in aged mice for the treatment of aging-related memory disturbances. Displays more efficient memory-enhancing effects than memantine (Cat. No. 0773) in Alzheimer's disease mouse models.

Technical Data

M. Wt 418.07
Formula C14H13BrINO
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 304679-75-2
PubChem ID 9888248
InChI Key LERUHBBUGAOYOD-UHFFFAOYSA-M
Smiles BrC1=CC=C(C(CC2=[N+](C)C=CC=C2)=O)C=C1.[I-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.81 100
water 4.18 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 418.07. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.39 mL 11.96 mL 23.92 mL
5 mM 0.48 mL 2.39 mL 4.78 mL
10 mM 0.24 mL 1.2 mL 2.39 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Lagostena et al (2008) The partial α7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus. Neuropharmacology 54 676 PMID: 18187166

Marighetto et al (2008) Comparative effects of the α7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against aging-related deficits in declarative and working memory in mice. Psychopharmacology. 197 499 PMID: 18265960

Beracochea et al (2008) Improvement of contextual memory by S 24795 in aged mice: comparison with memantine. Psychopharmacology 196 555 PMID: 18034231


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Citations for S 24795

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