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Biological Activity for S 24795
S 24795 is a partial agonist of α7 nAChR. Improves mnemonic function in aged mice for the treatment of aging-related memory disturbances. Displays more efficient memory-enhancing effects than memantine (Cat. No. 0773) in Alzheimer's disease mouse models.
Technical Data for S 24795
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for S 24795
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||4.18||10 with gentle warming|
Preparing Stock Solutions for S 24795
The following data is based on the product molecular weight 418.07. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.39 mL||11.96 mL||23.92 mL|
|5 mM||0.48 mL||2.39 mL||4.78 mL|
|10 mM||0.24 mL||1.2 mL||2.39 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
References for S 24795
References are publications that support the biological activity of the product.
Lagostena et al (2008) The partial α7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus. Neuropharmacology 54 676 PMID: 18187166
Marighetto et al (2008) Comparative effects of the α7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against aging-related deficits in declarative and working memory in mice. Psychopharmacology. 197 499 PMID: 18265960
Beracochea et al (2008) Improvement of contextual memory by S 24795 in aged mice: comparison with Mem.. Psychopharmacology 196 555 PMID: 18034231
If you know of a relevant reference for S 24795, please let us know.
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Keywords: S 24795, S 24795 supplier, S24795, partial, agonist, a7, nAChR, nicotinic, acetylcholine, receptor, α7, agonists, Nicotinic, (a7), Receptors, 3518, Tocris Bioscience
Citations for S 24795
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.