S 24795

Pricing Availability   Qty
Description: α7 nAChR partial agonist
Chemical Name: 2-[2-(4-Bromophenyl)-2-oxoethyl]-1-methylpyridinium iodide
Purity: ≥99% (HPLC)
Literature (2)

Biological Activity for S 24795

S 24795 is a partial agonist of α7 nAChR. Improves mnemonic function in aged mice for the treatment of aging-related memory disturbances. Displays more efficient memory-enhancing effects than memantine (Cat. No. 0773) in Alzheimer's disease mouse models.

Technical Data for S 24795

M. Wt 418.07
Formula C14H13BrINO
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 304679-75-2
PubChem ID 9888248
Smiles BrC1=CC=C(C(CC2=[N+](C)C=CC=C2)=O)C=C1.[I-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for S 24795

Solvent Max Conc. mg/mL Max Conc. mM
water 4.18 10 with gentle warming
DMSO 41.81 100

Preparing Stock Solutions for S 24795

The following data is based on the product molecular weight 418.07. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.39 mL 11.96 mL 23.92 mL
5 mM 0.48 mL 2.39 mL 4.78 mL
10 mM 0.24 mL 1.2 mL 2.39 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets for S 24795

Certificate of Analysis / Product Datasheet
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References for S 24795

References are publications that support the biological activity of the product.

Lagostena et al (2008) The partial α7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus. Neuropharmacology 54 676 PMID: 18187166

Marighetto et al (2008) Comparative effects of the α7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against aging-related deficits in declarative and working memory in mice. Psychopharmacology. 197 499 PMID: 18265960

Beracochea et al (2008) Improvement of contextual memory by S 24795 in aged mice: comparison with Mem.. Psychopharmacology 196 555 PMID: 18034231

If you know of a relevant reference for S 24795, please let us know.

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Citations for S 24795

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Currently there are no citations for S 24795. Do you know of a great paper that uses S 24795 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.