Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewS 24795
Description: α7 nAChR partial agonist
Chemical Name: 2-[2-(4-Bromophenyl)-2-oxoethyl]-1-methylpyridinium iodide
Purity: ≥99% (HPLC)
Biological Activity for S 24795
S 24795 is a partial agonist of α7 nAChR. Improves mnemonic function in aged mice for the treatment of aging-related memory disturbances. Displays more efficient memory-enhancing effects than memantine (Cat. No. 0773) in Alzheimer's disease mouse models.
Technical Data for S 24795
| M. Wt | 418.07 |
| Formula | C14H13BrINO |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 304679-75-2 |
| PubChem ID | 9888248 |
| InChI Key | LERUHBBUGAOYOD-UHFFFAOYSA-M |
| Smiles | BrC1=CC=C(C(CC2=[N+](C)C=CC=C2)=O)C=C1.[I-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for S 24795
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 4.18 | 10 with gentle warming | |
| DMSO | 41.81 | 100 |
Preparing Stock Solutions for S 24795
The following data is based on the product molecular weight 418.07. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.39 mL | 11.96 mL | 23.92 mL |
| 5 mM | 0.48 mL | 2.39 mL | 4.78 mL |
| 10 mM | 0.24 mL | 1.2 mL | 2.39 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for S 24795
References for S 24795
References are publications that support the biological activity of the product.
Lagostena et al (2008) The partial α7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus. Neuropharmacology 54 676 PMID: 18187166
Marighetto et al (2008) Comparative effects of the α7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against aging-related deficits in declarative and working memory in mice. Psychopharmacology. 197 499 PMID: 18265960
Beracochea et al (2008) Improvement of contextual memory by S 24795 in aged mice: comparison with Mem.. Psychopharmacology 196 555 PMID: 18034231
If you know of a relevant reference for S 24795, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: S 24795, S 24795 supplier, S24795, partial, agonist, a7, nAChR, nicotinic, acetylcholine, receptor, α7, agonists, Nicotinic, (a7), Receptors, 3518, Tocris Bioscience
Citations for S 24795
Citations are publications that use Tocris products.
Currently there are no citations for S 24795. Do you know of a great paper that uses S 24795 from Tocris? Please let us know.
Reviews for S 24795
There are currently no reviews for this product. Be the first to review S 24795 and earn rewards!
Have you used S 24795?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.