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An antagonist at the NMDA receptor, binding to the ion channel site. Used in the treatment of Parkinsonism.
Deuterated analog also available.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 100 mM in water|
References are publications that support the biological activity of the product.
Chen et al (1998) Neuroprotective concentrations of the N-MthD.-aspartate open-channel blocker Mem. are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation. Neuroscience 86 1121 PMID: 9697119
Parsons et al (1999) Mem. is a clinically well tolerated N-MthD.-aspartate (NMDA) receptor antagonist - a review of preclinical data. Neuropharmacology 38 735 PMID: 10465680
Parsons et al (2007) Mem.: A NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system - too little activation is bad, too much is even worse. Neuropharmacology 53 699 PMID: 17904591
Zajaczkowski et al (1997) Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP. Neuropharmacology 36 961 PMID: 9257940
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Keywords: Memantine hydrochloride, Memantine hydrochloride supplier, NMDA, antagonists, ion, channel, site, glutamate, receptors, N-Methyl-D-Aspartate, iGluR, ionotropic, Receptors, 0773, Tocris Bioscience
17 Citations for Memantine hydrochloride
Citations are publications that use Tocris products. Selected citations for Memantine hydrochloride include:
Birnbaum et al (2015) Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss. J Neurosci 6 e1791 PMID: 26086964
Campbell et al (2015) Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia. Invest Ophthalmol Vis Sci 8 425 PMID: 25565960
Carlson et al (2012) Pharmacological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica. Brain Behav 2 391 PMID: 22950043
Fan and Cooper (2009) Glutamate-induced NFκB activation in the retina. Proc Natl Acad Sci U S A 50 917 PMID: 18836176
Simma et al (2014) NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells. Front Cell Neurosci 12 75 PMID: 25477292
Puddifoot et al (2009) Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes. Br J Pharmacol 156 509 PMID: 19154422
Rzeski et al (2001) Glutamate antagonists limit tumor growth. FASEB J 98 6372 PMID: 11331750
Bali et al (2019) Cognitive enhancer effects of low Mem. doses are facilitated by an alpha7 nicotinic acetylcholine receptor agonist in scopolamine-induced amnesia in rats. Front Pharmacol 10 73 PMID: 30804787
Manning et al (2008) NMDA receptor blockade with Mem. attenuates white matter injury in a rat model of periventricular leukomalacia. Cell Commun Signal 28 6670 PMID: 18579741
Bouchard-Cannon et al (2018) Dexras1 is a homeostatic regulator of exercise-dependent proliferation and cell survival in the hippocampal neurogenic niche. Sci Rep 8 5294 PMID: 29593295
Léveillé et al (2008) Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors. FASEB J 22 4258 PMID: 18711223
Costa et al (2008) Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition. J Neurosci 28 8040 PMID: 18685029
Kaufman et al (2012) Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons. Cell Death Dis 32 3992 PMID: 22442066
He and Bausch (2014) Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic Mem. treatment in an in vitro model of limbic epileptogenesis. J Neurosci 77 379 PMID: 24184417
Jaekel et al (2006) Neuroprotection associated with alternative splicing of NMDA receptors in rat cortical neurons. Neuropharmacology 147 622 PMID: 16314856
Hedegaard et al (2012) Molecular pharmacology of human NMDA receptors. Neurochem Int 61 601 PMID: 22197913
Sachser et al (2016) Forgetting of long-term memory requires activation of NMDA receptors, L-type voltage-dependent Ca(2+) channels, and calcineurin. Sci Rep 6 22771 PMID: 26947131
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Reviews for Memantine hydrochloride
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We have been using memantine hydrochloride from Tocris for behavioral pharmacology and in vivo electrophysiology in rats. In electrophysiology experiments, memantine was delivered with microiontophoresis into the close vicinity of the neurons during recording in the rat cerebral cortex. Memantine was successfully applied from glass micropipettes of multi-barrel electrodes with positive constant currents at acidic pH, and it exerted the expected effect on hippocampal neurons (see attached figure of a representative recording).In behavioral experiments, memantine enhanced cognitive function in scopolamine-induced transient amnesia in rats. However, we found that memantine was effective at substantially lower doses compared to most of the publications from other laboratories.
It is recommended to always perform an initial experiment for the assessment of the dose-response curve, and not to rely on available literature data regarding suggested suitable doses, since the effect of memantine may substantially differ in different assays or behavioral paradigms.
Literature in this Area
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*Please note that Tocris will only send literature to established scientific business / institute addresses.
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Huntington's Disease Poster
Huntington's disease (HD) is a monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the MSN intracellular signaling pathways implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.