Memantine hydrochloride

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Cat.No. 0773 - Memantine hydrochloride | C12H21N.HCl | CAS No. 41100-52-1
Description: NMDA antagonist; acts at ion channel site
Chemical Name: 3,5-Dimethyl-tricyclo[3.3.1.13,7]decan-1-amine hydrochloride
Datasheet
Citations (13)
Literature

Biological Activity

An antagonist at the NMDA receptor, binding to the ion channel site. Used in the treatment of Parkinsonism.

Technical Data

M. Wt 215.77
Formula C12H21N.HCl
Storage Store at RT
CAS Number 41100-52-1
PubChem ID 181458
InChI Key LDDHMLJTFXJGPI-UHFFFAOYSA-N
Smiles NC12CC3(CC(C1)(CC(C2)C3)C)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 215.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.63 mL 23.17 mL 46.35 mL
5 mM 0.93 mL 4.63 mL 9.27 mL
10 mM 0.46 mL 2.32 mL 4.63 mL
50 mM 0.09 mL 0.46 mL 0.93 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Chen et al (1998) Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation. Neuroscience 86 1121 PMID: 9697119

Parsons et al (1999) Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist - a review of preclinical data. Neuropharmacology 38 735 PMID: 10465680

Parsons et al (2007) Memantine: A NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system - too little activation is bad, too much is even worse. Neuropharmacology 53 699 PMID: 17904591

Zajaczkowski et al (1997) Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP. Neuropharmacology 36 961 PMID: 9257940


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Keywords: Memantine hydrochloride, supplier, NMDA, antagonists, ion, channel, site, glutamate, receptors, N-Methyl-D-Aspartate, iGluR, ionotropic, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience

13 Citations for Memantine hydrochloride

Citations are publications that use Tocris products. Selected citations for Memantine hydrochloride include:

Simma et al (2014) NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells. Front Cell Neurosci 12 75 PMID: 25477292

He and Bausch (2014) Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic memantine treatment in an in vitro model of limbic epileptogenesis. J Neurosci 77 379 PMID: 24184417

Hedegaard et al (2012) Molecular pharmacology of human NMDA receptors. Neurochem Int 61 601 PMID: 22197913

Kaufman et al (2012) Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons. Cell Death Dis 32 3992 PMID: 22442066

Birnbaum et al (2015) Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss. J Neurosci 6 e1791 PMID: 26086964

Campbell et al (2015) Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia. Invest Ophthalmol Vis Sci 8 425 PMID: 25565960

Puddifoot et al (2009) Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes. Br J Pharmacol 156 509 PMID: 19154422

Fan and Cooper (2009) Glutamate-induced NFκB activation in the retina. Proc Natl Acad Sci U S A 50 917 PMID: 18836176

Léveillé et al (2008) Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors. FASEB J 22 4258 PMID: 18711223

Costa et al (2008) Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition. J Neurosci 28 8040 PMID: 18685029

Manning et al (2008) NMDA receptor blockade with memantine attenuates white matter injury in a rat model of periventricular leukomalacia. Cell Commun Signal 28 6670 PMID: 18579741

Jaekel et al (2006) Neuroprotection associated with alternative splicing of NMDA receptors in rat cortical neurons. Neuropharmacology 147 622 PMID: 16314856

Rzeski et al (2001) Glutamate antagonists limit tumor growth. FASEB J 98 6372 PMID: 11331750


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