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Potent thromboxane A2 (TP) inhibitor (IC50 = 16.4 nM). Inhibits U 46619 (Cat. No. 1932) induced human platelet aggregation and contraction of isolated rabbit saphenous vein in vitro. Also inhibits U 46619 induced increase in tracheal pressure in guinea pigs. Orally available.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||8.16||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 407.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.45 mL||12.26 mL||24.52 mL|
|5 mM||0.49 mL||2.45 mL||4.9 mL|
|10 mM||0.25 mL||1.23 mL||2.45 mL|
|50 mM||0.05 mL||0.25 mL||0.49 mL|
References are publications that support the biological activity of the product.
Cimetière et al (1998) Synthesis and biological evaluation of new tetrahydronaphthalene derivatives as thromboxane receptor antagonists. Bioorg.Med.Chem.Lett. 8 1375 PMID: 9871769
Wang et al (2014) Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists. ACS Med.Chem.Lett. 5 1015 PMID: 25221659
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Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.