S 18886

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Cat.No. 5568 - S 18886 | C20H22ClNO4S | CAS No. 165538-40-9
Description: Potent thromboxane A2 (TP) antagonist
Alternative Names: terutroban
Chemical Name: (6R)-6-[[(4-Chlorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydro-2-methyl-1-naphthalenepropanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent thromboxane A2 (TP) inhibitor (IC50 = 16.4 nM). Inhibits U 46619 (Cat. No. 1932) induced human platelet aggregation and contraction of isolated rabbit saphenous vein in vitro. Also inhibits U 46619 induced increase in tracheal pressure in guinea pigs. Orally available.

Compound Libraries

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Technical Data

M. Wt 407.91
Formula C20H22ClNO4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 165538-40-9
PubChem ID 9938840
InChI Key HWEOXFSBSQIWSY-MRXNPFEDSA-N
Smiles CC1=CC=C(C[C@H](NS(C2=CC=C(Cl)C=C2)(=O)=O)CC3)C3=C1CCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.79 100
ethanol 8.16 20 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 407.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.26 mL 24.52 mL
5 mM 0.49 mL 2.45 mL 4.9 mL
10 mM 0.25 mL 1.23 mL 2.45 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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References

References are publications that support the biological activity of the product.

Cimetière et al (1998) Synthesis and biological evaluation of new tetrahydronaphthalene derivatives as thromboxane receptor antagonists. Bioorg.Med.Chem.Lett. 8 1375 PMID: 9871769

Wang et al (2014) Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists. ACS Med.Chem.Lett. 5 1015 PMID: 25221659


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