S 18886

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Description: Potent thromboxane A2 (TP) antagonist
Alternative Names: terutroban
Chemical Name: (6R)-6-[[(4-Chlorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydro-2-methyl-1-naphthalenepropanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
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Biological Activity for S 18886

S 18886 is a potent thromboxane A2 (TP) inhibitor (IC50 = 16.4 nM). Inhibits U 46619 (Cat. No. 1932) induced human platelet aggregation and contraction of isolated rabbit saphenous vein in vitro. Also inhibits U 46619 induced increase in tracheal pressure in guinea pigs. Orally available.

Compound Libraries for S 18886

S 18886 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for S 18886

M. Wt 407.91
Formula C20H22ClNO4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 165538-40-9
PubChem ID 9938840
InChI Key HWEOXFSBSQIWSY-MRXNPFEDSA-N
Smiles CC1=CC=C(C[C@H](NS(C2=CC=C(Cl)C=C2)(=O)=O)CC3)C3=C1CCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for S 18886

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.79 100
ethanol 8.16 20 with gentle warming

Preparing Stock Solutions for S 18886

The following data is based on the product molecular weight 407.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.26 mL 24.52 mL
5 mM 0.49 mL 2.45 mL 4.9 mL
10 mM 0.25 mL 1.23 mL 2.45 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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References for S 18886

References are publications that support the biological activity of the product.

Cimetière et al (1998) Synthesis and biological evaluation of new tetrahydronaphthalene derivatives as thromboxane receptor antagonists. Bioorg.Med.Chem.Lett. 8 1375 PMID: 9871769

Wang et al (2014) Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists. ACS Med.Chem.Lett. 5 1015 PMID: 25221659


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Citations for S 18886

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