U 46619
Biological Activity
PGH2 (TXA2) analog that is a potent and stable thromboxane A2 (TP) receptor agonist (EC50 = 0.035 μM). Potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. Activates ERK-1 and ERK-2 in HEK 293 cells expressing TPα and TPβ receptors.
Technical Data
| M. Wt | 350.5 |
| Formula | C21H34O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 56985-40-1 |
| PubChem ID | 5311493 |
| InChI Key | LQANGKSBLPMBTJ-BRSNVKEHSA-N |
| Smiles | O[C@@H](CCCCC)/C=C/[C@H]1[C@@H]2OC[C@@H](C2)[C@@H]1C/C=C\CCCC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble in methyl acetate (supplied pre-dissolved -10mg/ml) |
Preparing Stock Solutions
The following data is based on the product molecular weight 350.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.85 mL | 14.27 mL | 28.53 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.71 mL |
| 10 mM | 0.29 mL | 1.43 mL | 2.85 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
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References
References are publications that support the products' biological activity.
Coleman et al (1981) Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle preparations. Br.J.Pharmacol. 73 773 PMID: 7248665
Morinelli et al (1987) Receptor-mediated effects of a PGH2 analogue (U 46619) on human platelets. Am.J.Physiol. 253 H1035 PMID: 3688248
Miggin and Kinsella (2002) Regulation of extracellular signal-regulated kinase cascades by α- and β-isoforms of the human thromboxane A2 receptor. Mol.Pharmacol. 61 817 PMID: 11901221
If you know of a relevant reference for U 46619, please let us know.
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Keywords: Potent stable thromboxane A2 TP receptor agonists TXA2 Prostanoid prostaglandins prostacyclins eicosanoids U46619 9 11-Dideoxy-9a 11a-methanoepoxy prostaglandinF2a 9,11-Dideoxy-9a,11a-methanoepoxy prostaglandin F2a Prostanoid Receptors
6 Citations for U 46619
Citations are publications that use Tocris products. Selected citations for U 46619 include:
Choi et al (2016) Inhibition of endoplasmic reticulum stress improves coronary artery function in the spontaneously hypertensive rats. Scientific Reports 6 31925 PMID: 27550383
Lee and Diamond (2015) A human platelet calcium calculator trained by pairwise agonist scanning. PLoS One 11 e1004118 PMID: 25723389
Pike et al (2014) Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence. Sci Rep 4 4705 PMID: 24740086
Seto et al (2013) Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. Diabetes 8 e66404 PMID: 23799098
Lacar et al (2012) S phase entry of neural progenitor cells correlates with increased blood flow in the young subventricular zone. PLoS One 7 e31960 PMID: 22359646
Chapman et al (2012) Platelets present antigen in the context of MHC class I. J Immunol 189 916 PMID: 22706078
Do you know of a great paper that uses U 46619 from Tocris? If so please let us know.
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