U 46619

Pricing Availability   Qty
Description: Potent, stable thromboxane A2 (TP) receptor agonist
Alternative Names: 9,11-Dideoxy-9a,11a-methanoepoxy prostaglandin F2a
Chemical Name: (5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]-5-heptenoic acid
Purity: ≥98% (HPLC)
Citations (9)

Biological Activity for U 46619

U 46619 is a PGH2 (TXA2) analog that is a potent and stable thromboxane A2 (TP) receptor agonist (EC50 = 0.035 μM). Potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. Activates ERK-1 and ERK-2 in HEK 293 cells expressing TPα and TPβ receptors.

Technical Data for U 46619

M. Wt 350.5
Formula C21H34O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 56985-40-1
PubChem ID 5311493
Smiles O[C@@H](CCCCC)/C=C/[C@H]1[C@@H]2OC[C@@H](C2)[C@@H]1C/C=C\CCCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for U 46619

Solubility Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)

Product Datasheets for U 46619

Certificate of Analysis / Product Datasheet
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References for U 46619

References are publications that support the biological activity of the product.

Coleman et al (1981) Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle preparations. Br.J.Pharmacol. 73 773 PMID: 7248665

Morinelli et al (1987) Receptor-mediated effects of a PGH2 analogue (U 46619) on human platelets. Am.J.Physiol. 253 H1035 PMID: 3688248

Miggin and Kinsella (2002) Regulation of extracellular signal-regulated kinase cascades by α- and β-isoforms of the human thromboxane A2 receptor. Mol.Pharmacol. 61 817 PMID: 11901221

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Keywords: U 46619, U 46619 supplier, Potent, stable, thromboxane, A2, TP, receptor, agonists, TXA2, Prostanoid, prostaglandins, prostacyclins, eicosanoids, U46619, 9, 11-Dideoxy-9a, 11a-methanoepoxy, prostaglandinF2a, 9,11-Dideoxy-9a,11a-methanoepoxy, prostaglandin, F2a, Receptors, 1932, Tocris Bioscience

9 Citations for U 46619

Citations are publications that use Tocris products. Selected citations for U 46619 include:

Coleman et al (2014) New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1. Mol Pharmacol 86 342 PMID: 24958817

Pike et al (2014) Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence. Sci Rep 4 4705 PMID: 24740086

Seto et al (2013) Acute SimV. inhibits K ATP channels of porcine coronary artery myocytes. Diabetes 8 e66404 PMID: 23799098

Lee and Diamond (2015) A human platelet calcium calculator trained by pairwise agonist scanning. PLoS One 11 e1004118 PMID: 25723389

Do you know of a great paper that uses U 46619 from Tocris? Please let us know.

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