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Submit ReviewS 07662 is an inverse agonist of the constitutive androstane receptor (CAR). Inhibits CAR activity via recruitment of nuclear receptor co-repressor (NCoR). Suppresses CITCO-induced CYP2B6 gene expression in human primary hepatocytes.
M. Wt | 300.38 |
Formula | C16H16N2O2S |
Storage | Store at +4°C |
Purity | ≥98% (HPLC) |
CAS Number | 883226-64-0 |
PubChem ID | 2732040 |
InChI Key | UITFWLJMEZPXOF-UHFFFAOYSA-N |
Smiles | CC2=C(CNC(NCC3=CC=CS3)=O)C1=CC=CC=C1O2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 30.04 | 100 | |
ethanol | 15.02 | 50 |
The following data is based on the product molecular weight 300.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 3.33 mL | 16.65 mL | 33.29 mL |
5 mM | 0.67 mL | 3.33 mL | 6.66 mL |
10 mM | 0.33 mL | 1.66 mL | 3.33 mL |
50 mM | 0.07 mL | 0.33 mL | 0.67 mL |
References are publications that support the biological activity of the product.
Küblbeck et al (2011) New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists. Mol.Pharm. 8 2424 PMID: 22044162
If you know of a relevant reference for S 07662, please let us know.
Keywords: S 07662, S 07662 supplier, S07662, inverse, agonists, constitutive, androstane, receptors, CAR, nuclear, Constitutive, Androstane, Receptor, 5188, Tocris Bioscience
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