S 07662

Pricing Availability   Qty
Cat.No. 5188 - S 07662 | C16H16N2O2S | CAS No. 883226-64-0
Description: Constitutive androstane receptor (CAR) inverse agonist
Chemical Name: N-[(2-Methyl-3-benzofuranyl)methyl]-N'-(2-thienylmethyl)urea
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Inverse agonist of the constitutive androstane receptor (CAR). Inhibits CAR activity via recruitment of nuclear receptor co-repressor (NCoR). Suppresses CITCO-induced CYP2B6 gene expression in human primary hepatocytes.

Compound Libraries

S 07662 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 300.38
Formula C16H16N2O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 883226-64-0
PubChem ID 2732040
InChI Key UITFWLJMEZPXOF-UHFFFAOYSA-N
Smiles CC2=C(CNC(NCC3=CC=CS3)=O)C1=CC=CC=C1O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.04 100
ethanol 15.02 50

Preparing Stock Solutions

The following data is based on the product molecular weight 300.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.33 mL 16.65 mL 33.29 mL
5 mM 0.67 mL 3.33 mL 6.66 mL
10 mM 0.33 mL 1.66 mL 3.33 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Küblbeck et al (2011) New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists. Mol.Pharm. 8 2424 PMID: 22044162


If you know of a relevant reference for S 07662, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Constitutive Androstane Receptor Inverse Agonists

Keywords: S 07662, S 07662 supplier, S07662, inverse, agonists, constitutive, androstane, receptors, CAR, nuclear, Constitutive, Androstane, Receptor, 5188, Tocris Bioscience

Citations for S 07662

Citations are publications that use Tocris products.

Currently there are no citations for S 07662. Do you know of a great paper that uses S 07662 from Tocris? Please let us know.

Reviews for S 07662

There are currently no reviews for this product. Be the first to review S 07662 and earn rewards!

Have you used S 07662?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors