S 07662

Pricing Availability Delivery Time Qty
Cat.No. 5188 - S 07662 | C16H16N2O2S | CAS No. 883226-64-0
Description: Inverse agonist of the constitutive androstane receptor (CAR)
Chemical Name: N-[(2-Methyl-3-benzofuranyl)methyl]-N'-(2-thienylmethyl)urea
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inverse agonist of the constitutive androstane receptor (CAR). Inhibits CAR activity via recruitment of nuclear receptor co-repressor (NCoR). Suppresses CITCO-induced CYP2B6 gene expression in human primary hepatocytes.

Compound Libraries

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Technical Data

M. Wt 300.38
Formula C16H16N2O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 883226-64-0
PubChem ID 2732040
InChI Key UITFWLJMEZPXOF-UHFFFAOYSA-N
Smiles CC2=C(CNC(NCC3=CC=CS3)=O)C1=CC=CC=C1O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.04 100
ethanol 15.02 50

Preparing Stock Solutions

The following data is based on the product molecular weight 300.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.33 mL 16.65 mL 33.29 mL
5 mM 0.67 mL 3.33 mL 6.66 mL
10 mM 0.33 mL 1.66 mL 3.33 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Küblbeck et al (2011) New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists. Mol.Pharm. 8 2424 PMID: 22044162


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View all Constitutive Androstane Receptor Antagonists

Keywords: S07662 inverse agonists constitutive androstane receptors CAR nuclear Constitutive Androstane Receptor

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Nuclear Receptors

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