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S 07662

Cat. No. 5188 Submit a Review Datasheet / COA / SDS
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Description: Constitutive androstane receptor (CAR) inverse agonist
Chemical Name: N-[(2-Methyl-3-benzofuranyl)methyl]-N'-(2-thienylmethyl)urea
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for S 07662

S 07662 is an inverse agonist of the constitutive androstane receptor (CAR). Inhibits CAR activity via recruitment of nuclear receptor co-repressor (NCoR). Suppresses CITCO-induced CYP2B6 gene expression in human primary hepatocytes.

Technical Data for S 07662

M. Wt 300.38
Formula C16H16N2O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 883226-64-0
PubChem ID 2732040
InChI Key UITFWLJMEZPXOF-UHFFFAOYSA-N
Smiles CC2=C(CNC(NCC3=CC=CS3)=O)C1=CC=CC=C1O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for S 07662

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.04 100
ethanol 15.02 50

Preparing Stock Solutions for S 07662

The following data is based on the product molecular weight 300.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.33 mL 16.65 mL 33.29 mL
5 mM 0.67 mL 3.33 mL 6.66 mL
10 mM 0.33 mL 1.66 mL 3.33 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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References for S 07662

References are publications that support the biological activity of the product.

Küblbeck et al (2011) New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists. Mol.Pharm. 8 2424 PMID: 22044162

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Citations for S 07662

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