CITCO

Pricing Availability   Qty
Description: Selective CAR agonist
Chemical Name: 6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews

Biological Activity for CITCO

CITCO is a constitutive androstane receptor (CAR) agonist (EC50 = 49 nM). Displays > 100-fold selectivity over PXR receptors and no activity at LXR, ERα, ERβ, PPAR, RAR, FXR, VDR and THR. Induces CAR nuclear translocation and expression of CYP2B6 in hepatocytes in vitro.

Compound Libraries for CITCO

CITCO is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CITCO

M. Wt 436.74
Formula C19H12Cl3N3OS
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 338404-52-7
PubChem ID 9600409
InChI Key ZQWBOKJVVYNKTL-AUEPDCJTSA-N
Smiles ClC(C(Cl)=C4)=CC=C4CO/N=C/C1=C(C3=CC=C(Cl)C=C3)N=C2N1C=CS2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CITCO

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.84 50

Preparing Stock Solutions for CITCO

The following data is based on the product molecular weight 436.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.58 mL 22.9 mL 45.79 mL
2.5 mM 0.92 mL 4.58 mL 9.16 mL
5 mM 0.46 mL 2.29 mL 4.58 mL
25 mM 0.09 mL 0.46 mL 0.92 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for CITCO

Certificate of Analysis / Product Datasheet
Select another batch:

References for CITCO

References are publications that support the biological activity of the product.

Maglich et al (2003) Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. J.Biol.Chem. 278 17277 PMID: 12611900

Clen et al (2009) A single amino acid controls the functional switch of human CAR1 to the xenobiotic sensitive splicing variant CAR3. J.Pharmacol.Exp.Ther. 332 106 PMID: 19820207

Moreau et al (2007) Constitutive androstane receptor-vitamin D receptor crosstalk: consequence on CYP24 gene expression. Biochem.Biophys.Res.Comm. 360 76 PMID: 17585873


If you know of a relevant reference for CITCO, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Constitutive Androstane Receptor Agonists

Keywords: CITCO, CITCO supplier, Selective, CAR, agonists, Constitutive, androstane, VDR-like, receptors, Androstane, Receptor, 3683, Tocris Bioscience

Reviews for CITCO

There are currently no reviews for this product. Be the first to review CITCO and earn rewards!

Have you used CITCO?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review