RWJ 52353

Pricing Availability Delivery Time Qty
Cat.No. 3935 - RWJ 52353 | C11H10N2S | CAS No. 245744-10-9
Description: α2D agonist
Chemical Name: 5-(6,7-Dihydrobenzo[b]thien-4-yl-1H-imidazole hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Agonist of the α2D adrenergic receptor (Ki values are 1.5, 254, 443 and 621 nM for α2D, α2A, α1 and α2B adrenergic receptors respectively).

Technical Data

M. Wt 202.28
Formula C11H10N2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 245744-10-9
PubChem ID 71752148
InChI Key LIHWQUZNTRDJFW-UHFFFAOYSA-N
Smiles C1(SC=C2)=C2C(C3=CN=CN3)=CCC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.11 50
ethanol 10.11 50

Preparing Stock Solutions

The following data is based on the product molecular weight 202.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.94 mL 24.72 mL 49.44 mL
5 mM 0.99 mL 4.94 mL 9.89 mL
10 mM 0.49 mL 2.47 mL 4.94 mL
50 mM 0.1 mL 0.49 mL 0.99 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ross et al (2000) α2 adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-imidazo)-1,3-dimethyl-6,7-dihydrothianaphthene as a high-affinity ligand for the α2D adrenergic receptor. J.Med.Chem. 43 765 PMID: 10753480

Amphoux et al (2010) Inhibitory and facilitatory actions of isocyanine derivatives at human and rat organic cation transporters 1, 2 and 3: a comparison to human α1- and α2-adrenoceptor subtypes. Eur.J.Pharmacol. 634 1 PMID: 20170649


If you know of a relevant reference for RWJ 52353, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Adrenergic α2 Receptor Agonists

Keywords: RWJ52353 agonists alpha2D a2d α2d adrenergic receptors adrenoceptors Adrenergic Alpha-2 Receptors

Citations for RWJ 52353

Citations are publications that use Tocris products.

Currently there are no citations for RWJ 52353. Do you know of a great paper that uses RWJ 52353 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Pathways for RWJ 52353

Protocols

TODO: Add Protocols