RWJ 50271

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Cat.No. 4227 - RWJ 50271 | C18H17F3N4O2S | CAS No. 162112-37-0
Description: Inhibitor of LFA-1/ICAM mediated cell adhesion
Chemical Name: N-(3-Hydroxypropyl)-5-methyl-1-[-4-[3-(trifluoromethyl)phenyl)]-2-thiazolyl]-1H-pyrazole-4-carboxamide
Purity: ≥99% (HPLC)

Biological Activity

Selective inhibitor of LFA-1 (lymphocyte function-associated antigen-1) adhesion to soluble intercellular adhesion molecule (sICAM) (IC50 = 5 μM in HL60 cells).

Compound Libraries

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Technical Data

M. Wt 410.41
Formula C18H17F3N4O2S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 162112-37-0
PubChem ID 9953357
Smiles CC1=C(C(NCCCO)=O)C=NN1C2=NC(C3=CC(C(F)(F)F)=CC=C3)=CS2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 41.04 100
ethanol 4.1 10

Preparing Stock Solutions

The following data is based on the product molecular weight 410.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.18 mL 24.37 mL
5 mM 0.49 mL 2.44 mL 4.87 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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Product Datasheets

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References are publications that support the products' biological activity.

Sanfilippo et al (1995) Novel thiazole based heterocycles as inhibitors of LFA-1/ICAM-1 mediated cell adhesion. J.Med.Chem. 38 1057 PMID: 7707308

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Keywords: RWJ50271 inhibitors inhibits LFA-1/ICAM-1 adhesion sICAM lymphocyte function-associated antigen-1 Integrins

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Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation

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