RWJ 50271

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Cat.No. 4227 - RWJ 50271 | C18H17F3N4O2S | CAS No. 162112-37-0
Description: Inhibitor of LFA-1/ICAM mediated cell adhesion
Chemical Name: N-(3-Hydroxypropyl)-5-methyl-1-[-4-[3-(trifluoromethyl)phenyl)]-2-thiazolyl]-1H-pyrazole-4-carboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Selective inhibitor of LFA-1 (lymphocyte function-associated antigen-1) adhesion to soluble intercellular adhesion molecule (sICAM) (IC50 = 5 μM in HL60 cells).

Compound Libraries

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Technical Data

M. Wt 410.41
Formula C18H17F3N4O2S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 162112-37-0
PubChem ID 9953357
InChI Key HOFGTYCLOKDAES-UHFFFAOYSA-N
Smiles CC1=C(C(NCCCO)=O)C=NN1C2=NC(C3=CC(C(F)(F)F)=CC=C3)=CS2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.04 100
ethanol 4.1 10

Preparing Stock Solutions

The following data is based on the product molecular weight 410.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.18 mL 24.37 mL
5 mM 0.49 mL 2.44 mL 4.87 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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References

References are publications that support the biological activity of the product.

Sanfilippo et al (1995) Novel thiazole based heterocycles as inhibitors of LFA-1/ICAM-1 mediated cell adhesion. J.Med.Chem. 38 1057 PMID: 7707308


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Keywords: RWJ 50271, RWJ 50271 supplier, RWJ50271, inhibitors, inhibits, LFA-1/ICAM-1, adhesion, sICAM, lymphocyte, function-associated, antigen-1, Integrins, Cell, Adhesion, Molecules, 4227, Tocris Bioscience

1 Citation for RWJ 50271

Citations are publications that use Tocris products. Selected citations for RWJ 50271 include:

Takizawa (2017) Bone marrow-derived mesenchymal stem cells propagate immunosuppressive/anti-inflammatorymacrophages in cell-to-cell contact-independent and dependent manners under hypoxic culture. Exp Cell Res 358 441 PMID: 28712928


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