Rupintrivir

Discontinued Product

Rupintrivir (Cat. No. 6414) has been withdrawn from sale for commercial reasons.
Cat.No. 6414 - Rupintrivir | C31H39FN4O7 | CAS No. 223537-30-2
Description: Potent and selective irreversible human rhinovirus 3Cpro inhibitor
Chemical Name: Ethyl (2E,4S)-4-[[(2R,5S)-2-[(4-fluorophenyl)methyl]-6-methyl-5-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-1,4-dioxoheptyl]amino]-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for Rupintrivir

Rupintrivir is a potent and selective irreversible human rhinovirus (HRV) 3C protease inhibitor (EC50 = 5 nM). Exhibits no significant inhibition against a variety of serine and cysteine proteases. Inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays.

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for Rupintrivir

M. Wt 598.66
Formula C31H39FN4O7
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 223537-30-2
PubChem ID 6440352CAY
InChI Key CAYJBRBGZBCZKO-BHGBQCOSSA-N
Smiles O=C(C1=NOC(C)=C1)N[C@@H](C(C)C)C(C[C@@H](CC2=CC=C(F)C=C2)C(N[C@H](/C=C/C(OCC)=O)C[C@@H]3CCNC3=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Rupintrivir

References are publications that support the biological activity of the product.

Patick et al (1999) In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob.Agents Chemother. 43 2444 PMID: 10508022

Dragovich et al (1999) Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics. J.Med.Chem. 42 1203 PMID: 10197964

View Related Products by Product Action

View all 3C and 3CL Protease Inhibitors

Keywords: Rupintrivir, Rupintrivir supplier, HRV, inhibits, inhibitors, Potent, selective, irreversible, human, rhinovirus, 3C, protease, and, 3CL, Proteases, Other, Antivirals, 6414, Tocris Bioscience

Citations for Rupintrivir

Citations are publications that use Tocris products.

Currently there are no citations for Rupintrivir.

Reviews for Rupintrivir

There are currently no reviews for this product. Be the first to review Rupintrivir and earn rewards!

Have you used Rupintrivir?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Immunology Product Listing

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation