Rupintrivir

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Cat.No. 6414 - Rupintrivir | C31H39FN4O7 | CAS No. 223537-30-2
Description: Potent and selective irreversible human rhinovirus 3C protease inhibitor
Chemical Name: Ethyl (2E,4S)-4-[[(2R,5S)-2-[(4-fluorophenyl)methyl]-6-methyl-5-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-1,4-dioxoheptyl]amino]-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective irreversible human rhinovirus (HRV) 3C protease inhibitor (EC50 = 5 nM). Exhibits no significant inhibition against a variety of serine and cysteine proteases. Inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 598.66
Formula C31H39FN4O7
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 223537-30-2
PubChem ID 6440352CAY
InChI Key CAYJBRBGZBCZKO-BHGBQCOSSA-N
Smiles O=C(C1=NOC(C)=C1)N[C@@H](C(C)C)C(C[C@@H](CC2=CC=C(F)C=C2)C(N[C@H](/C=C/C(OCC)=O)C[C@@H]3CCNC3=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 59.87 100

Preparing Stock Solutions

The following data is based on the product molecular weight 598.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.67 mL 8.35 mL 16.7 mL
5 mM 0.33 mL 1.67 mL 3.34 mL
10 mM 0.17 mL 0.84 mL 1.67 mL
50 mM 0.03 mL 0.17 mL 0.33 mL

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References

References are publications that support the biological activity of the product.

Patick et al (1999) In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob.Agents Chemother. 43 2444 PMID: 10508022

Dragovich et al (1999) Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics. J.Med.Chem. 42 1203 PMID: 10197964


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Keywords: Rupintrivir, Rupintrivir supplier, HRV, inhibits, inhibitors, Potent, selective, irreversible, human, rhinovirus, 3C, protease, Other, Proteases, Antivirals, 6414, Tocris Bioscience

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