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Cat.No. 6414 - Rupintrivir | C31H39FN4O7 | CAS No. 223537-30-2
Description: Potent and selective irreversible human rhinovirus 3Cpro inhibitor
Chemical Name: Ethyl (2E,4S)-4-[[(2R,5S)-2-[(4-fluorophenyl)methyl]-6-methyl-5-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-1,4-dioxoheptyl]amino]-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoate
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for Rupintrivir

Rupintrivir is a potent and selective irreversible human rhinovirus (HRV) 3C protease inhibitor (EC50 = 5 nM). Exhibits no significant inhibition against a variety of serine and cysteine proteases. Inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays.

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for Rupintrivir

M. Wt 598.66
Formula C31H39FN4O7
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 223537-30-2
PubChem ID 6440352CAY
Smiles O=C(C1=NOC(C)=C1)N[C@@H](C(C)C)C(C[C@@H](CC2=CC=C(F)C=C2)C(N[C@H](/C=C/C(OCC)=O)C[C@@H]3CCNC3=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Rupintrivir

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 59.87 100

Preparing Stock Solutions for Rupintrivir

The following data is based on the product molecular weight 598.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.67 mL 8.35 mL 16.7 mL
5 mM 0.33 mL 1.67 mL 3.34 mL
10 mM 0.17 mL 0.84 mL 1.67 mL
50 mM 0.03 mL 0.17 mL 0.33 mL

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References for Rupintrivir

References are publications that support the biological activity of the product.

Patick et al (1999) In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob.Agents Chemother. 43 2444 PMID: 10508022

Dragovich et al (1999) Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics. J.Med.Chem. 42 1203 PMID: 10197964

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Citations for Rupintrivir

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