RuBi-Glutamate

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Cat.No. 3574 - RuBi-Glutamate | C28H32N5O4PRu.2NaPF6
Description: Caged glutamate; excited by visible wavelengths
Chemical Name: (bis(2,2'-Bipyridine-N,N')trimethylphosphine)-(S)-1-aminopropane-1,3-dicarboxylic acid ruthenium(2+) complex sodium hexafluorophosphate salt
Datasheet
Citations (1)
Literature

Biological Activity

Ruthenium-bipyridine-trimethylphosphine caged glutamate that can be excited by visible wavelengths and releases glutamate after one- or two-photon excitation. Has high quantum efficiency and can be used at low concentrations, partly avoiding blockade of GABAergic transmission seen with other caged glutamate compounds. Displays high spatial resolution and generates excitatory responses in individual dendritic spines with physiological kinetics.

Licensing Information

Sold under licence from Columbia University

Technical Data

M. Wt 970.54
Formula C28H32N5O4PRu.2NaPF6
Storage Store at -20°C
PubChem ID 90488860
InChI Key SQQVSHWHIPVYSZ-UHFFFAOYSA-L
Smiles [Na+].[Na+].[Ru++].CP(C)C.F[P-](F)(F)(F)(F)F.F[P-](F)(F)(F)(F)F.NC(CCC([O-])=O)C([O-])=O.C1=CN=C(C=C1)C1=CC=CC=N1.C1=CN=C(C=C1)C1=CC=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 16.07 20

Preparing Stock Solutions

The following data is based on the product molecular weight 970.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.03 mL 5.15 mL 10.3 mL
5 mM 0.21 mL 1.03 mL 2.06 mL
10 mM 0.1 mL 0.52 mL 1.03 mL
50 mM 0.02 mL 0.1 mL 0.21 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Fino et al (2009) RuBi-Glutamate: two-photon and visible-light photoactivation of neurons and dendritic spines. Front.Neural Circuits 3 1 PMID: 19506708

Salierno et al (2010) A fast ruthenium polypyridine cage complex photoreleases glutamate with visible or IR light in one and two photon regimes. J.Inorg.Biochem. 104 418 PMID: 20060592


If you know of a relevant reference for RuBi-Glutamate, please let us know.

Keywords: RuBi-Glutamate, supplier, Caged, Glutamate, mGluR, iGluR, Receptors, agonists, ionotropic, metabotropic, Caged, Glutamate, Compounds, Tocris Bioscience

1 Citation for RuBi-Glutamate

Citations are publications that use Tocris products. Selected citations for RuBi-Glutamate include:

Blaesse et al (2015) μ-Opioid Receptor-Mediated Inhibition of Intercalated Neurons and Effect on Synaptic Transmission to the Central Amygdala. Neuroscience 35 7317 PMID: 25972162


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Pathways for RuBi-Glutamate

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