RU 24969 hemisuccinate
Potent 5-HT1A/1B and moderate 5-HT2C agonist that may also release 5-HT. Centrally active following systemic administration.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 287.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.48 mL||17.4 mL||34.8 mL|
|5 mM||0.7 mL||3.48 mL||6.96 mL|
|10 mM||0.35 mL||1.74 mL||3.48 mL|
|50 mM||0.07 mL||0.35 mL||0.7 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Gudermann et al (1993) Human S31 serotonin receptor clone encodes a 5-hydroxytryptamine1E-like serotonin receptor. Mol.Pharmacol. 43 412 PMID: 8450834
Tomkins and O'Neill (2000) Effect of 5-HT1B receptor ligands on self-administration of ethanol in an operant procedure in rats. Pharmacol.Biochem.Behav. 66 129 PMID: 10837852
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Keywords: 5-HT1B/1A agonists Serotonin Receptors RU24969 hemisuccinate C14H16N2O.0.5C4H6O4 5-HT1A Receptors
1 Citation for RU 24969 hemisuccinate
Citations are publications that use Tocris products. Selected citations for RU 24969 hemisuccinate include:
Lawson et al (2016) Effects of Oxytocin on Serotonin 1B Agonist-induced Autism-like Behavior in Mice Behavioural Brain Research 314 52 PMID: 27439030
Do you know of a great paper that uses RU 24969 hemisuccinate from Tocris? If so please let us know.
Literature in this Area
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
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