RU 24969 hemisuccinate

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Description: 5-HT1A and 5-HT1B agonist
Chemical Name: 5-Methoxy-3-(1,2,5,6-tetrahydro-4-pyridinyl)-1H-indole hemisuccinate
Purity: ≥99% (HPLC)
Citations (1)
Reviews (1)
Literature (3)

Biological Activity for RU 24969 hemisuccinate

RU 24969 hemisuccinate is a potent 5-HT1A/1B and moderate 5-HT2C agonist that may also release 5-HT. Centrally active following systemic administration.

Technical Data for RU 24969 hemisuccinate

M. Wt 287.34
Formula C14H16N2O.½C4H6O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 66611-27-6
PubChem ID 3050530

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RU 24969 hemisuccinate

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 14.37 50
water 8.62 30

Preparing Stock Solutions for RU 24969 hemisuccinate

The following data is based on the product molecular weight 287.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.96 mL 34.8 mL 69.6 mL
2.5 mM 1.39 mL 6.96 mL 13.92 mL
5 mM 0.7 mL 3.48 mL 6.96 mL
25 mM 0.14 mL 0.7 mL 1.39 mL

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Product Datasheets for RU 24969 hemisuccinate

Certificate of Analysis / Product Datasheet
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References for RU 24969 hemisuccinate

References are publications that support the biological activity of the product.

Gudermann et al (1993) Human S31 serotonin receptor clone encodes a 5-hydroxytryptamine1E-like serotonin receptor. Mol.Pharmacol. 43 412 PMID: 8450834

Tomkins and O'Neill (2000) Effect of 5-HT1B receptor ligands on self-administration of ethanol in an operant procedure in rats. Pharmacol.Biochem.Behav. 66 129 PMID: 10837852

Guillaume et al (1987) Synthesis of 3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles and study of their serotonergic and antiDArgic properties. Eur.J.Med.Chem. 22 33

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Keywords: RU 24969 hemisuccinate, RU 24969 hemisuccinate supplier, 5-HT1B/1A, agonists, Serotonin, Receptors, RU24969, hemisuccinate, C14H16N2O.0.5C4H6O4, 5-HT1A, 0912, Tocris Bioscience

1 Citation for RU 24969 hemisuccinate

Citations are publications that use Tocris products. Selected citations for RU 24969 hemisuccinate include:

Lawson et al (2016) Effects of oxyt. on Serotonin 1B Agonist-induced Autism-like Behavior in Mice Behavioural Brain Research 314 52 PMID: 27439030

Do you know of a great paper that uses RU 24969 hemisuccinate from Tocris? Please let us know.

Reviews for RU 24969 hemisuccinate

Average Rating: 5 (Based on 1 Review.)

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5-HT1B agonist-induced social and attention deficits in mice.
By Anonymous on 05/09/2020
Assay Type: In Vivo
Species: Mouse
Cell Line/Tissue: brain

Drug treatment 0 or 10 mg/kg RU24969

PMID: 27439030 Reference
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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.