(RS)-MCPG disodium salt

Pricing Availability   Qty
Description: Non-selective mGlu antagonist; disodium salt of (RS)-MCPG (Cat. No. 0336)
Chemical Name: (RS)-α-Methyl-4-carboxyphenylglycine disodium salt
Purity: ≥99% (HPLC)
Citations (2)
Reviews (1)
Literature (2)

Biological Activity for (RS)-MCPG disodium salt

(RS)-MCPG disodium salt is a sodium salt of (RS)-MCPG, a non-selective group I/group II metabotropic glutamate receptor antagonist.

S-enantiomer also available.

Technical Data for (RS)-MCPG disodium salt

M. Wt 253.16
Formula C10H9NNa2O4
Storage Store at RT
Purity ≥99% (HPLC)
PubChem ID 90488871
Smiles [Na+].[Na+].CC(N)(C([O-])=O)C1=CC=C(C=C1)C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (RS)-MCPG disodium salt

Solvent Max Conc. mg/mL Max Conc. mM
water 25.32 100

Preparing Stock Solutions for (RS)-MCPG disodium salt

The following data is based on the product molecular weight 253.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.95 mL 19.75 mL 39.5 mL
5 mM 0.79 mL 3.95 mL 7.9 mL
10 mM 0.4 mL 1.98 mL 3.95 mL
50 mM 0.08 mL 0.4 mL 0.79 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for (RS)-MCPG disodium salt

Certificate of Analysis / Product Datasheet
Select another batch:

References for (RS)-MCPG disodium salt

References are publications that support the biological activity of the product.

Collingridge and Watkins (1994) Phenylglycine derivatives as metabotropic glutamate receptor antagonists. TiPS 15 333 PMID: 7992387

Joly et al (1995) Molecular, functional and pharmacological characterization of the metabotropic glutamate receptor Type 5 splice variants: comparison with mGluR1. J.Neurosci. 15 3970 PMID: 7751958

Eaton et al (1993) Competitive antagonist at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine (CPG) and (RS)-α-methyl-4-carboxyphenylglycine (MCPG). Eur.J.Pharmacol.Mol.Pharmacol.Sect. 244 195

If you know of a relevant reference for (RS)-MCPG disodium salt, please let us know.

View Related Products by Product Action

View all Non-selective Metabotropic Glutamate Antagonists

Keywords: (RS)-MCPG disodium salt, (RS)-MCPG disodium salt supplier, Non-Selective, mGlur, antagonists, Group, I, II, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, mGlu1, mGlu5, mGluR1, mGluR5, 1303994-09-3, Non-selective, mGlu, 3696, Tocris Bioscience

2 Citations for (RS)-MCPG disodium salt

Citations are publications that use Tocris products. Selected citations for (RS)-MCPG disodium salt include:

Hajime et al (2022) Activation of Glutamate Transport Increases Arteriole Diameter in v ivo: Implications for Neurovascular Coupling. Front Cell Neurosci 16 831061 PMID: 35308116

David D et al (2019) Distinct Modes of Presynaptic Inhibition of Cutaneous Afferents and Their Functions in Behavior. Neuron 102 420-434.e8 PMID: 30826183

Do you know of a great paper that uses (RS)-MCPG disodium salt from Tocris? Please let us know.

Reviews for (RS)-MCPG disodium salt

Average Rating: 5 (Based on 1 Review.)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used (RS)-MCPG disodium salt?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

Suppression of mGluR action triggered by glutamate application.
By Sergiy Sylantyev on 10/15/2020
Species: Human
Cell Line/Tissue: Stem cell - derived neurons

(RS)-MCPG disodium salt was in use to prevent contamination of NMDA-receptor – generated response to prolonged application of glutamate with (possible) impact from metabotropic glutamate receptors (mGluRs). APV, applied after glutamate, fully suppressed NMDA-receptor response, thus suggesting no input from mGluRs (see illustration). MCPG disodium salt works as expected; the effects and time interval for response development are same with those of (RS)-MCPG, but the salt is much easier soluble.

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.