(RS)-MCPG disodium salt

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Cat.No. 3696 - (RS)-MCPG disodium salt | C10H9NNa2O4
Description: Non-selective mGlu antagonist; disodium salt of (RS)-MCPG (Cat. No. 0336)
Chemical Name: (RS)-α-Methyl-4-carboxyphenylglycine disodium salt
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (6)

Biological Activity

Sodium salt of (RS)-MCPG, a non-selective group I/group II metabotropic glutamate receptor antagonist.

S-enantiomer also available.

Technical Data

M. Wt 253.16
Formula C10H9NNa2O4
Storage Store at RT
Purity ≥99% (HPLC)
PubChem ID 90488871
InChI Key YGOTXTUQJLFNHB-UHFFFAOYSA-L
Smiles [Na+].[Na+].CC(N)(C([O-])=O)C1=CC=C(C=C1)C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 25.32 100

Preparing Stock Solutions

The following data is based on the product molecular weight 253.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.95 mL 19.75 mL 39.5 mL
5 mM 0.79 mL 3.95 mL 7.9 mL
10 mM 0.4 mL 1.98 mL 3.95 mL
50 mM 0.08 mL 0.4 mL 0.79 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Collingridge and Watkins (1994) Phenylglycine derivatives as metabotropic glutamate receptor antagonists. TiPS 15 333 PMID: 7992387

Joly et al (1995) Molecular, functional and pharmacological characterization of the metabotropic glutamate receptor Type 5 splice variants: comparison with mGluR1. J.Neurosci. 15 3970 PMID: 7751958

Eaton et al (1993) Competitive antagonist at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine (CPG) and (RS)-α-methyl-4-carboxyphenylglycine (MCPG). Eur.J.Pharmacol.Mol.Pharmacol.Sect. 244 195


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Citations for (RS)-MCPG disodium salt

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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