Discontinued ProductUnfortunately (RS)-α-Methyl-3-carboxymethylphenylglycine (Cat. No. 0856) has been withdrawn from sale for commercial reasons.
Group I/group II mGlu antagonist at cloned receptors.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 223.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.48 mL||22.4 mL||44.8 mL|
|5 mM||0.9 mL||4.48 mL||8.96 mL|
|10 mM||0.45 mL||2.24 mL||4.48 mL|
|50 mM||0.09 mL||0.45 mL||0.9 mL|
References are publications that support the products' biological activity.
Bedingfield et al (1995) Structure-activity relationships for a series of phenylglycine derivatives at metabotropic glutamate receptors (mGluRs). Br.J.Pharmacol. 116 3323 PMID: 8719814
Sekiyama et al (1996) Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br.J.Pharmacol. 117 1493 PMID: 8730745
Watkins and Collingridge (1994) Phenylglycine derivatives as antagonists of metabotropic glutamate receptors. TiPS 15 333 PMID: 7992387
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Keywords: (RS)-a-Methyl-3-carboxymethylphenylglycine, supplier, Non-selective, mGlu, Non-selective, mGlu, Tocris Bioscience
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Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.