RS 67506 hydrochloride

Discontinued Product

RS 67506 hydrochloride (Cat. No. 0990) has been withdrawn from sale for commercial reasons.
Cat.No. 0990 - RS 67506 hydrochloride | C18H28ClN3O4S.HCl | CAS No. 168986-61-6
Description: 5-HT4 partial agonist
Chemical Name: 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-2-methylsulphonylamino)ethyl-4-piperidinyl]-1-propanone hydrochloride
Datasheet
Citations (1)
Reviews
Literature (4)

Biological Activity for RS 67506 hydrochloride

RS 67506 hydrochloride is a potent and selective 5-HT4 partial agonist, with a pKi of 8.8 at 5-HT4 sites in guinea pig striatum, but < 6.0 at several other receptors including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. It is active in vivo and has an intrinsic activity compared to 5-HT of 0.6.

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data for RS 67506 hydrochloride

M. Wt 454.41
Formula C18H28ClN3O4S.HCl
Storage Store at RT
CAS Number 168986-61-6
PubChem ID 133075
InChI Key GFWKWEHKHLTRRF-UHFFFAOYSA-N
Smiles Cl.COC1=C(C=C(Cl)C(N)=C1)C(=O)CCC1CCN(CCNS(C)(=O)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for RS 67506 hydrochloride

Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service

References for RS 67506 hydrochloride

References are publications that support the biological activity of the product.

Eglen et al (1995) Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo. Br.J.Pharmacol. 115 1387 PMID: 8564196

Eglen et al (1995) Central 5-HT4 receptors. TiPS 16 391 PMID: 8578609

Fontana et al (1997) The effects of novel, selective 5-hydroxytryptamine (5HT)4 ligands in rat spatial navigation. Neuropharmacology 36 689 PMID: 9225295

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Keywords: RS 67506 hydrochloride, RS 67506 hydrochloride supplier, 5-HT4, partial, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, RS67506, hydrochloride, 0990, Tocris Bioscience

1 Citation for RS 67506 hydrochloride

Citations are publications that use Tocris products. Selected citations for RS 67506 hydrochloride include:

Garavaglia et al (2010) Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates. BMC Neurosci 11 7 PMID: 20085655


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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