RS 67506 hydrochloride

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Cat.No. 0990 - RS 67506 hydrochloride | C18H28ClN3O4S.HCl | CAS No. 168986-61-6
Description: 5-HT4 partial agonist
Chemical Name: 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-2-methylsulphonylamino)ethyl-4-piperidinyl]-1-propanone hydrochloride
Datasheet
Citations (1)
Literature

Biological Activity

A potent and selective 5-HT4 partial agonist, with a pKi of 8.8 at 5-HT4 sites in guinea pig striatum, but < 6.0 at several other receptors including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. It is active in vivo and has an intrinsic activity compared to 5-HT of 0.6.

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data

M. Wt 454.41
Formula C18H28ClN3O4S.HCl
Storage Store at RT
CAS Number 168986-61-6
PubChem ID 133075
InChI Key GFWKWEHKHLTRRF-UHFFFAOYSA-N
Smiles Cl.COC1=C(C=C(Cl)C(N)=C1)C(=O)CCC1CCN(CCNS(C)(=O)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 80 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 454.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.2 mL 11 mL 22.01 mL
5 mM 0.44 mL 2.2 mL 4.4 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service.
Safety Datasheet

References

References are publications that support the products' biological activity.

Eglen et al (1995) Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo. Br.J.Pharmacol. 115 1387 PMID: 8564196

Eglen et al (1995) Central 5-HT4 receptors. TiPS 16 391 PMID: 8578609

Fontana et al (1997) The effects of novel, selective 5-hydroxytryptamine (5HT)4 ligands in rat spatial navigation. Neuropharmacology 36 689 PMID: 9225295


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1 Citation for RS 67506 hydrochloride

Citations are publications that use Tocris products. Selected citations for RS 67506 hydrochloride include:

Garavaglia et al (2010) Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates. BMC Neurosci 11 7 PMID: 20085655


Do you know of a great paper that uses RS 67506 hydrochloride from Tocris? If so please let us know.

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Pathways for RS 67506 hydrochloride

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