RS 67506 hydrochloride

Discontinued Product

RS 67506 hydrochloride (Cat. No. 0990) has been withdrawn from sale for commercial reasons.
Description: 5-HT4 partial agonist
Chemical Name: 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-2-methylsulphonylamino)ethyl-4-piperidinyl]-1-propanone hydrochloride
Citations (1)
Literature (2)

Biological Activity for RS 67506 hydrochloride

RS 67506 hydrochloride is a potent and selective 5-HT4 partial agonist, with a pKi of 8.8 at 5-HT4 sites in guinea pig striatum, but < 6.0 at several other receptors including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. It is active in vivo and has an intrinsic activity compared to 5-HT of 0.6.

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data for RS 67506 hydrochloride

M. Wt 454.41
Formula C18H28ClN3O4S.HCl
Storage Store at RT
CAS Number 168986-61-6
PubChem ID 133075
Smiles Cl.COC1=C(C=C(Cl)C(N)=C1)C(=O)CCC1CCN(CCNS(C)(=O)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for RS 67506 hydrochloride

Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service

References for RS 67506 hydrochloride

References are publications that support the biological activity of the product.

Eglen et al (1995) Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo. Br.J.Pharmacol. 115 1387 PMID: 8564196

Eglen et al (1995) Central 5-HT4 receptors. TiPS 16 391 PMID: 8578609

Fontana et al (1997) The effects of novel, selective 5-hydroxytryptamine (5HT)4 ligands in rat spatial navigation. Neuropharmacology 36 689 PMID: 9225295

View Related Products by Target

View Related Products by Product Action

View all 5-HT4 Receptor Agonists

Keywords: RS 67506 hydrochloride, RS 67506 hydrochloride supplier, 5-HT4, partial, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, RS67506, hydrochloride, 0990, Tocris Bioscience

1 Citation for RS 67506 hydrochloride

Citations are publications that use Tocris products. Selected citations for RS 67506 hydrochloride include:

Garavaglia et al (2010) Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates. BMC Neurosci 11 7 PMID: 20085655

Reviews for RS 67506 hydrochloride

There are currently no reviews for this product. Be the first to review RS 67506 hydrochloride and earn rewards!

Have you used RS 67506 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.