RS 67333 hydrochloride

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Cat.No. 0989 - RS 67333 hydrochloride | C19H29ClN2O2.HCl | CAS No. 168986-60-5
Description: 5-HT4 partial agonist
Chemical Name: 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-butyl-4-piperidinyl]-1-propanone hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Reviews
Literature

Biological Activity

A potent and highly selective 5-HT4 partial agonist, with pKi values of 8.7 at 5-HT4 sites in guinea pig striatum and > 6 at various other receptors, including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. Active in vivo, with an intrinsic activity relative to 5-HT of 0.5.

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data

M. Wt 389.36
Formula C19H29ClN2O2.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 168986-60-5
PubChem ID 9800491
InChI Key XVBGLZNYWUUAFF-UHFFFAOYSA-N
Smiles Cl.CCCCN1CCC(CCC(=O)C2=CC(Cl)=C(N)C=C2OC)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 9.73 25mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 389.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.57 mL 12.84 mL 25.68 mL
5 mM 0.51 mL 2.57 mL 5.14 mL
10 mM 0.26 mL 1.28 mL 2.57 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Eglen et al (1995) Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo. Br.J.Pharmacol. 115 1387 PMID: 8564196

Eglen et al (1995) Central 5-HT4 receptors. TiPS 16 391 PMID: 8578609

Fontana et al (1997) The effects of novel, selective 5-hydroxytryptamine (5HT)4 receptor ligands in rat spatial navigation. Neuropharmacology 36 689 PMID: 9225295


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Keywords: RS 67333 hydrochloride, supplier, 5-HT4, partial, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, RS67333, hydrochloride, 5-HT4, Receptors, 5-HT4, Receptors, Tocris Bioscience

5 Citations for RS 67333 hydrochloride

Citations are publications that use Tocris products. Selected citations for RS 67333 hydrochloride include:

Eriksson et al (2013) Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11. Learn Mem 18 1096 PMID: 23032875

Müller et al (2009) 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS One 4 e6453 PMID: 19649285

Warner-Schmidt et al (2009) Role of p11 in cellular and behavioral effects of 5-HT4 receptor stimulation. J Neurosci 29 1937 PMID: 19211900

Huang and Kandel (2007) Low-frequency stimulation induces a pathway-specific late phase of LTP in the amygdala that is mediated by PKA and dependent on protein synthesis. J Neurosci 14 497 PMID: 17626908

Huang and Kandel (2007) 5-Hydroxytryptamine induces a protein kinase A/mitogen-activated protein kinase-mediated and macromolecular synthesis-dependent late phase of long-term potentiation in the amygdala. Obesity (Silver Spring) 27 3111 PMID: 17376972


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