PKG inhibitor (Ki values are 0.45, 0.5 and 0.7 μM for PKGIβ, PKGIα and PKGII respectively). Exhibits selectivity for PKG over PKA and Epac-1. Reduces LTP in hippocampal slices in vitro.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 525.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.9 mL||9.51 mL||19.02 mL|
|5 mM||0.38 mL||1.9 mL||3.8 mL|
|10 mM||0.19 mL||0.95 mL||1.9 mL|
|50 mM||0.04 mL||0.19 mL||0.38 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Kim et al (2015) Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors. Proc.Natl.Acad.Sci.U.S.A. 112 3122 PMID: 25713349
Poppe et al (2008) Cyclic nucleotide analogs as probes of signaling pathways. Nat.Methods 5 277 PMID: 18376388
Gamm et al (1995) The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms. J.Biol.Chem. 270 27380 PMID: 7593002
If you know of a relevant reference for Rp-8-pCPT-cGMPS sodium, please let us know.
View Related Products by Product Action
Keywords: PKG cGMP-dependent kinases PKGIbeta PKGIb PKGIμ PKGIalpha PKGIa PKGIα PKGII LTP potentiation long term Protein Kinase G
Citations for Rp-8-pCPT-cGMPS sodium
Citations are publications that use Tocris products.
Currently there are no citations for Rp-8-pCPT-cGMPS sodium. Do you know of a great paper that uses Rp-8-pCPT-cGMPS sodium from Tocris? If so please let us know.