Rp-8-pCPT-cGMPS sodium

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Description: PKG inhibitor
Chemical Name: 8-[(4-Chlorophenyl)thio]-guanosine-cyclic 3',5'-[hydrogen [P(R)]-phosphorothioate] sodium
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (4)

Biological Activity for Rp-8-pCPT-cGMPS sodium

Rp-8-pCPT-cGMPS sodium is a PKG inhibitor (Ki values are 0.45, 0.5 and 0.7 μM for PKGIβ, PKGIα and PKGII respectively). Exhibits selectivity for PKG over PKA and Epac-1. Reduces LTP in hippocampal slices in vitro.

Technical Data for Rp-8-pCPT-cGMPS sodium

M. Wt 525.86
Formula C16H14ClN5NaO6PS2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 208445-07-2
PubChem ID 91826097
InChI Key JERAACMSJYSCBY-OZOPYAHTSA-M
Smiles O=C1N=C(N)NC2=C1N=C(SC4=CC=C(Cl)C=C4)N2[C@@H]3O[C@@](CO[P@](O5)(S[Na])=O)([H])[C@]5([H])[C@H]3O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Rp-8-pCPT-cGMPS sodium

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 52.59 100
DMSO 52.59 100

Preparing Stock Solutions for Rp-8-pCPT-cGMPS sodium

The following data is based on the product molecular weight 525.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.9 mL 9.51 mL 19.02 mL
5 mM 0.38 mL 1.9 mL 3.8 mL
10 mM 0.19 mL 0.95 mL 1.9 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets for Rp-8-pCPT-cGMPS sodium

References for Rp-8-pCPT-cGMPS sodium

References are publications that support the biological activity of the product.

Kim et al (2015) Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors. Proc.Natl.Acad.Sci.U.S.A. 112 3122 PMID: 25713349

Poppe et al (2008) Cyclic nucleotide analogs as probes of signaling pathways. Nat.Methods 5 277 PMID: 18376388

Gamm et al (1995) The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms. J.Biol.Chem. 270 27380 PMID: 7593002


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Keywords: Rp-8-pCPT-cGMPS sodium, Rp-8-pCPT-cGMPS sodium supplier, PKG, cGMP-dependent, kinases, PKGIbeta, PKGIb, PKGIμ, PKGIalpha, PKGIa, PKGIα, PKGII, LTP, potentiation, long, term, Protein, Kinase, G, 5524, Tocris Bioscience

1 Citation for Rp-8-pCPT-cGMPS sodium

Citations are publications that use Tocris products. Selected citations for Rp-8-pCPT-cGMPS sodium include:

Govindapillai et al (2018) Characterizing the role of atrial natriuretic peptide signaling in the development of embryonic ventricular conduction system. Sci Rep 8 6939 PMID: 29720615


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Literature in this Area

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