Rp-8-pCPT-cGMPS sodium

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: PKG inhibitor
Chemical Name: 8-[(4-Chlorophenyl)thio]-guanosine-cyclic 3',5'-[hydrogen [P(R)]-phosphorothioate] sodium
Purity: ≥99% (HPLC)
Citations (1)
Literature (1)

Biological Activity for Rp-8-pCPT-cGMPS sodium

Rp-8-pCPT-cGMPS sodium is a PKG inhibitor (Ki values are 0.45, 0.5 and 0.7 μM for PKGIβ, PKGIα and PKGII respectively). Exhibits selectivity for PKG over PKA and Epac-1. Reduces LTP in hippocampal slices in vitro.

Technical Data for Rp-8-pCPT-cGMPS sodium

M. Wt 525.86
Formula C16H14ClN5NaO6PS2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 208445-07-2
PubChem ID 91826097
Smiles O=C1N=C(N)NC2=C1N=C(SC4=CC=C(Cl)C=C4)N2[C@@H]3O[C@@](CO[P@](O5)(S[Na])=O)([H])[C@]5([H])[C@H]3O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Rp-8-pCPT-cGMPS sodium

Solvent Max Conc. mg/mL Max Conc. mM
water 52.59 100
DMSO 52.59 100

Preparing Stock Solutions for Rp-8-pCPT-cGMPS sodium

The following data is based on the product molecular weight 525.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.9 mL 9.51 mL 19.02 mL
5 mM 0.38 mL 1.9 mL 3.8 mL
10 mM 0.19 mL 0.95 mL 1.9 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Rp-8-pCPT-cGMPS sodium

References for Rp-8-pCPT-cGMPS sodium

References are publications that support the biological activity of the product.

Kim et al (2015) Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors. Proc.Natl.Acad.Sci.U.S.A. 112 3122 PMID: 25713349

Poppe et al (2008) Cyclic nucleotide analogs as probes of signaling pathways. Nat.Methods 5 277 PMID: 18376388

Gamm et al (1995) The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms. J.Biol.Chem. 270 27380 PMID: 7593002

If you know of a relevant reference for Rp-8-pCPT-cGMPS sodium, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Protein Kinase G Inhibitors

Keywords: Rp-8-pCPT-cGMPS sodium, Rp-8-pCPT-cGMPS sodium supplier, PKG, cGMP-dependent, kinases, PKGIbeta, PKGIb, PKGIμ, PKGIalpha, PKGIa, PKGIα, PKGII, LTP, potentiation, long, term, Protein, Kinase, G, 5524, Tocris Bioscience

1 Citation for Rp-8-pCPT-cGMPS sodium

Citations are publications that use Tocris products. Selected citations for Rp-8-pCPT-cGMPS sodium include:

Govindapillai et al (2018) Characterizing the role of atrial natriuretic peptide signaling in the development of embryonic ventricular conduction system. Sci Rep 8 6939 PMID: 29720615

Do you know of a great paper that uses Rp-8-pCPT-cGMPS sodium from Tocris? Please let us know.

Reviews for Rp-8-pCPT-cGMPS sodium

There are currently no reviews for this product. Be the first to review Rp-8-pCPT-cGMPS sodium and earn rewards!

Have you used Rp-8-pCPT-cGMPS sodium?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.