Rp-8-pCPT-cGMPS sodium

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Cat.No. 5524 - Rp-8-pCPT-cGMPS sodium | C16H14ClN5NaO6PS2 | CAS No. 208445-07-2
Description: PKG inhibitor
Chemical Name: 8-[(4-Chlorophenyl)thio]-guanosine-cyclic 3',5'-[hydrogen [P(R)]-phosphorothioate] sodium
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

PKG inhibitor (Ki values are 0.45, 0.5 and 0.7 μM for PKGIβ, PKGIα and PKGII respectively). Exhibits selectivity for PKG over PKA and Epac-1. Reduces LTP in hippocampal slices in vitro.

Technical Data

M. Wt 525.86
Formula C16H14ClN5NaO6PS2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 208445-07-2
PubChem ID 91826097
InChI Key JERAACMSJYSCBY-OZOPYAHTSA-M
Smiles O=C1N=C(N)NC2=C1N=C(SC4=CC=C(Cl)C=C4)N2[C@@H]3O[C@@](CO[P@](O5)(S[Na])=O)([H])[C@]5([H])[C@H]3O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 52.59 100
ethanol 52.59 100
water 52.59 100

Preparing Stock Solutions

The following data is based on the product molecular weight 525.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.9 mL 9.51 mL 19.02 mL
5 mM 0.38 mL 1.9 mL 3.8 mL
10 mM 0.19 mL 0.95 mL 1.9 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kim et al (2015) Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors. Proc.Natl.Acad.Sci.U.S.A. 112 3122 PMID: 25713349

Poppe et al (2008) Cyclic nucleotide analogs as probes of signaling pathways. Nat.Methods 5 277 PMID: 18376388

Gamm et al (1995) The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms. J.Biol.Chem. 270 27380 PMID: 7593002


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View all Protein Kinase G Inhibitors

Keywords: PKG cGMP-dependent kinases PKGIbeta PKGIb PKGIμ PKGIalpha PKGIa PKGIα PKGII LTP potentiation long term Protein Kinase G

Citations for Rp-8-pCPT-cGMPS sodium

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