Roxindole hydrochloride

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Cat.No. 1559 - Roxindole hydrochloride | C23H26N2O.HCl | CAS No. 108050-82-4
Description: Dopamine D2 autoreceptor agonist. Also has affinity for D3, D4, 5-HT1A receptors and the 5-HT transporter
Alternative Names: EMD 49980
Chemical Name: 3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-ol hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Dopamine D2 autoreceptor agonist, with affinity for D3, D4 and 5-HT1 receptors (pKi values are 8.55, 8.93, 8.23, 9.42, 6.00 and 7.05 for human D2, D3, D4, 5-HT1A, 5-HT1B and 5-HT1D receptors). Inhibits 5-HT uptake and is antidepressant in vivo.

Technical Data

M. Wt 382.93
Formula C23H26N2O.HCl
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 108050-82-4
PubChem ID 9886286
InChI Key ZCEPVNSWLLJECX-UHFFFAOYSA-N
Smiles OC(C=C4)=CC1=C4NC=C1CCCCN2CCC(C3=CC=CC=C3)=CC2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.15 50 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 382.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.22 mL 26.11 mL 52.23 mL
2.5 mM 1.04 mL 5.22 mL 10.45 mL
5 mM 0.52 mL 2.61 mL 5.22 mL
25 mM 0.1 mL 0.52 mL 1.04 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Bartoszyk et al (1996) Roxindole: psychopharmacological profile of a dopamine D2 autoreceptor agonist. J.Pharmacol.Exp.Ther. 276 41 PMID: 8558454

Newman-Tancredi et al (1999) Actions of roxindole at recombinant human dopamine D2, D3 and D4 and serotonin 5-HT1A, 5-HT1B and 5-HT1D receptors. Naunyn Schmiedebergs Arch.Pharmacol. 359 447 PMID: 10431754

Seyfried et al (1989) Biochemical and functional studies on EMD 49980: a potent, selectively presynaptic D-2 dopamine agonist with actions on serotonin systems. Eur.J.Pharmacol. 160 31 PMID: 2565817


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Citations for Roxindole hydrochloride

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Literature in this Area

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