Roxindole hydrochloride

Discontinued Product

Roxindole hydrochloride (Cat. No. 1559) has been withdrawn from sale for commercial reasons.
Description: Dopamine D2 autoreceptor agonist. Also has affinity for D3, D4, 5-HT1A receptors and the 5-HT transporter
Alternative Names: EMD 49980
Chemical Name: 3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-ol hydrochloride
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for Roxindole hydrochloride

Roxindole hydrochloride is a dopamine D2 autoreceptor agonist, with affinity for D3, D4 and 5-HT1 receptors (pKi values are 8.55, 8.93, 8.23, 9.42, 6.00 and 7.05 for human D2, D3, D4, 5-HT1A, 5-HT1B and 5-HT1D receptors). Inhibits 5-HT uptake and is antidepressant in vivo.

Technical Data for Roxindole hydrochloride

M. Wt 382.93
Formula C23H26N2O.HCl
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 108050-82-4
PubChem ID 9886286
Smiles OC(C=C4)=CC1=C4NC=C1CCCCN2CCC(C3=CC=CC=C3)=CC2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Roxindole hydrochloride

Certificate of Analysis / Product Datasheet
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References for Roxindole hydrochloride

References are publications that support the biological activity of the product.

Bartoszyk et al (1996) Roxindole: psychopharmacological profile of a DA D2 autoreceptor agonist. J.Pharmacol.Exp.Ther. 276 41 PMID: 8558454

Newman-Tancredi et al (1999) Actions of roxindole at recombinant human DA D2, D3 and D4 and serotonin 5-HT1A, 5-HT1B and 5-HT1D receptors. Naunyn Schmiedebergs Arch.Pharmacol. 359 447 PMID: 10431754

Seyfried et al (1989) Biochemical and functional studies on EMD 49980: a potent, selectively presynaptic D-2 DA agonist with actions on serotonin systems. Eur.J.Pharmacol. 160 31 PMID: 2565817

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Citations for Roxindole hydrochloride

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Currently there are no citations for Roxindole hydrochloride.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.