Dopamine D2 autoreceptor agonist, with affinity for D3, D4 and 5-HT1 receptors (pKi values are 8.55, 8.93, 8.23, 9.42, 6.00 and 7.05 for human D2, D3, D4, 5-HT1A, 5-HT1B and 5-HT1D receptors). Inhibits 5-HT uptake and is antidepressant in vivo.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||19.15||50mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 382.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.61 mL||13.06 mL||26.11 mL|
|5 mM||0.52 mL||2.61 mL||5.22 mL|
|10 mM||0.26 mL||1.31 mL||2.61 mL|
|50 mM||0.05 mL||0.26 mL||0.52 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Bartoszyk et al (1996) Roxindole: psychopharmacological profile of a dopamine D2 autoreceptor agonist. J.Pharmacol.Exp.Ther. 276 41 PMID: 8558454
Newman-Tancredi et al (1999) Actions of roxindole at recombinant human dopamine D2, D3 and D4 and serotonin 5-HT1A, 5-HT1B and 5-HT1D receptors. Naunyn Schmiedebergs Arch.Pharmacol. 359 447 PMID: 10431754
Seyfried et al (1989) Biochemical and functional studies on EMD 49980: a potent, selectively presynaptic D-2 dopamine agonist with actions on serotonin systems. Eur.J.Pharmacol. 160 31 PMID: 2565817
If you know of a relevant reference for Roxindole hydrochloride, please let us know.
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Keywords: Roxindole hydrochloride, supplier, 5-HT, reuptake, inhibitors, inhibits, affinity, 5-HT1A, receptors, D2, dopamine, dopaminergic, agonists, autoreceptor, D3, D4, transporters, Serotonin, 5-HT-, 5-Hydroxytryptamine, Receptors, D2-like, Non-Selective, EMD49980, EMD, 49980, Non-selective, Dopamine, Tocris Bioscience
Citations for Roxindole hydrochloride
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Literature in this Area
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Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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