Roscovitine

Pricing Availability Delivery Time Qty
Cat.No. 1332 - Roscovitine | CAS No. 186692-46-6
Description: Potent, selective cyclin-dependent kinase inhibitor
Chemical Name: (2R)-2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent, selective inhibitor of cyclin-dependent kinases (cdk). Inhibits cdc2/cyclin B (IC50 = 650 nM), cdk2/cyclin A (IC50 = 700 nM), cdk2/cyclin E (IC50 = 700 nM), cdk5 / p35 (IC50 = 160 nM) and is selective over cdk4/cyclin D1 and cdk6/cyclin D3 (IC50 > 100 μM). Also selective over a wide range of related kinases including ERK1 and ERK2. Arrests L1210 cells in G1 phase. Inhibits phosphorylation of vimentin in vivo. Antimitotic.

Technical Data

M. Wt 354.45
Formula C19H26N6O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 186692-46-6
PubChem ID 160355
InChI Key BTIHMVBBUGXLCJ-OAHLLOKOSA-N
Smiles OC[C@@H](CC)NC1=NC(N(C(C)C)C=N2)=C2C(NCC3=CC=CC=C3)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.44 100
ethanol 35.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 354.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.82 mL 14.11 mL 28.21 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
10 mM 0.28 mL 1.41 mL 2.82 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

De Azevedo et al (1997) Inhibition of cyclin-dependent kinases by purine analogues. Eur.J.Biochem. 243 518 PMID: 9030780

Meijer (1996) Chemical inhibitors of cyclin-dependent kinases. Trends Cell.Biol. 6 393 PMID: 15157522

Meijer et al (1997) Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur.J.Biochem. 243 527 PMID: 9030781


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View all Cyclin-Dependent Protein Kinase Inhibitors

Keywords: Potent selective inhibitors inhibits cyclin dependent kinases cdks cdc2 cyclin B cdk2 cyclin A cdk2 cyclin E cdk5 p35 antimitotic Cyclin-dependent Kinase

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