ROS 234 dioxalate

Discontinued Product

ROS 234 dioxalate (Cat. No. 2034) has been withdrawn from sale for commercial reasons.
Cat.No. 2034 - ROS 234 dioxalate | C13H15N5.2C2H2O4 | CAS No. 1781941-93-2
Description: Potent H3 antagonist
Chemical Name: N-[3-(1H-Imidazol-4-yl)propyl]-1H-benzimidazol-2-amine dioxalate
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity for ROS 234 dioxalate

ROS 234 dioxalate is a potent H3 antagonist (pKB at guinea-pig ileum H3-receptor = 9.46). Limited blood brain barrier permeability (ED50 = 19.12 mg/kg i.p.).

Technical Data for ROS 234 dioxalate

M. Wt 421.37
Formula C13H15N5.2C2H2O4
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1781941-93-2
PubChem ID 56972188
InChI Key JKTBCMILCFDKEJ-UHFFFAOYSA-N
Smiles O=C(O)C(O)=O.O=C(O)C(O)=O.C1(CCCNC2=NC3=C(C=CC=C3)N2)=CNC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for ROS 234 dioxalate

References for ROS 234 dioxalate

References are publications that support the biological activity of the product.

Ballabeni et al (2002) CNS access of selected H3-antagonists: ex vivo binding study in rats. Inflamm.Res. 51 S55 PMID: 12013409

Mor et al (2004) Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H3-antagonists. Bioorg.Med.Chem.Lett. 12 663

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Citations for ROS 234 dioxalate

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