ROS 234 dioxalate

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Cat.No. 2034 - ROS 234 dioxalate | C13H15N5.2C2H2O4 | CAS No. 184576-87-2
Description: Potent H3 antagonist
Chemical Name: N-[3-(1H-Imidazol-4-yl)propyl]-1H-benzimidazol-2-amine dioxalate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent H3 antagonist (pKB at guinea-pig ileum H3-receptor = 9.46). Limited blood brain barrier permeability (ED50 = 19.12 mg/kg i.p.).

Technical Data

M. Wt 421.37
Formula C13H15N5.2C2H2O4
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 184576-87-2
PubChem ID 56972188
InChI Key JKTBCMILCFDKEJ-UHFFFAOYSA-N
Smiles O=C(O)C(O)=O.O=C(O)C(O)=O.C1(CCCNC2=NC3=C(C=CC=C3)N2)=CNC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.07 50
water 21.07 50

Preparing Stock Solutions

The following data is based on the product molecular weight 421.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.87 mL 23.73 mL
5 mM 0.47 mL 2.37 mL 4.75 mL
10 mM 0.24 mL 1.19 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ballabeni et al (2002) CNS access of selected H3-antagonists: ex vivo binding study in rats. Inflamm.Res. 51 S55 PMID: 12013409

Mor et al (2004) Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H3-antagonists. Bioorg.Med.Chem.Lett. 12 663 PMID:


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Keywords: ROS 234 dioxalate, supplier, Potent, H3, antagonists, Receptors, Histamine, histaminergic, ROS234, dioxalate, Histamine, H3, Receptors, Histamine, H3, Receptors, Tocris Bioscience

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