ROS 234 dioxalate

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Cat.No. 2034 - ROS 234 dioxalate | C13H15N5.2C2H2O4 | CAS No. 1781941-93-2
Description: Potent H3 antagonist
Chemical Name: N-[3-(1H-Imidazol-4-yl)propyl]-1H-benzimidazol-2-amine dioxalate
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity

Potent H3 antagonist (pKB at guinea-pig ileum H3-receptor = 9.46). Limited blood brain barrier permeability (ED50 = 19.12 mg/kg i.p.).

Technical Data

M. Wt 421.37
Formula C13H15N5.2C2H2O4
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1781941-93-2
PubChem ID 56972188
InChI Key JKTBCMILCFDKEJ-UHFFFAOYSA-N
Smiles O=C(O)C(O)=O.O=C(O)C(O)=O.C1(CCCNC2=NC3=C(C=CC=C3)N2)=CNC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 21.07 50
DMSO 21.07 50

Preparing Stock Solutions

The following data is based on the product molecular weight 421.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.75 mL 23.73 mL 47.46 mL
2.5 mM 0.95 mL 4.75 mL 9.49 mL
5 mM 0.47 mL 2.37 mL 4.75 mL
25 mM 0.09 mL 0.47 mL 0.95 mL

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References

References are publications that support the biological activity of the product.

Ballabeni et al (2002) CNS access of selected H3-antagonists: ex vivo binding study in rats. Inflamm.Res. 51 S55 PMID: 12013409

Mor et al (2004) Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H3-antagonists. Bioorg.Med.Chem.Lett. 12 663


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