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ROS 234 dioxalate
Discontinued ProductROS 234 dioxalate (Cat. No. 2034) has been withdrawn from sale for commercial reasons.
Biological Activity for ROS 234 dioxalate
ROS 234 dioxalate is a potent H3 antagonist (pKB at guinea-pig ileum H3-receptor = 9.46). Limited blood brain barrier permeability (ED50 = 19.12 mg/kg i.p.).
Technical Data for ROS 234 dioxalate
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ROS 234 dioxalate
References for ROS 234 dioxalate
References are publications that support the biological activity of the product.
Ballabeni et al (2002) CNS access of selected H3-antagonists: ex vivo binding study in rats. Inflamm.Res. 51 S55 PMID: 12013409
Mor et al (2004) Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H3-antagonists. Bioorg.Med.Chem.Lett. 12 663
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Citations for ROS 234 dioxalate
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Currently there are no citations for ROS 234 dioxalate.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.