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RO 8191 is an IFNα receptor 2 (IFNAR2) agonist (EC50 = 0.2 μM). RO 8191 induces phosphorylation and activation of STAT1 and STAT2. RO 8191 inhibits hepatitis C (HCV) cell culture-produced infectious particles and HCV subgenomic replicon (IC50 values 0.20 μM and 0.17 μM, respectively) and inhibits hepatitis B virus replication in cell cultures (IC50 = 0.1 μM). In an animal model RO 8191 inhibits prion invasion and prolongs survival; it also reverses the inhibitory effect of integrin β6 (ITGB6) on the JAK/STAT3 signaling and the epithelial-to-mesenchymal transition pathway and inhibits the proliferation, invasion, and migration of cervical cancer cells. Orally bioavailable.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 373.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||53.59 mL||267.94 mL||535.88 mL|
|0.25 mM||10.72 mL||53.59 mL||107.18 mL|
|0.5 mM||5.36 mL||26.79 mL||53.59 mL|
|2.5 mM||1.07 mL||5.36 mL||10.72 mL|
References are publications that support the biological activity of the product.
Konishi et al (2012) An orally available, small-molecule interferon inhibits viral replication. Sci.Rep. 2 PMID: 22355771
Zheng et al (2021) Silencing of ITGB6 inhibits the progression of cervical carcinoma via regulating JAK/STAT3 signaling pathway. Ann.Transl.Med. 9 PMID: 34268416
Furutani et al (2019) An interferon-like small chemical compound CDM-3008 suppresses hepatitis B virus through induction of interferon-stimulated genes. PLoS One 14 PMID: 31188831
Ishibashi et al (2019) Type I interferon protects neurons from prions in in vivo models. Brain 142 PMID: 30753318
If you know of a relevant reference for RO 8191, please let us know.
Keywords: RO 8191, RO 8191 supplier, RO8191, IFNAR2, receptor, agonist, phosphorylates, IFNalpha, interferon, alpha, IFN-alpha, Cytokine, Receptors, Hepatitis, Viruses, Prion, Protein, 7375, Tocris Bioscience
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.