RO 8191

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Cat.No. 7375 - RO 8191 | C14H5F6N5O | CAS No. 691868-88-9
Description: IFNα receptor 2 agonist
Chemical Name: 8-(1,3,4-Oxadiazol-2-yl)-2,4-bis(trifluoromethyl)imidazo[1,2-a][1,8]naphthyridine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for RO 8191

RO 8191 is an IFNα receptor 2 (IFNAR2) agonist (EC50 = 0.2 μM). RO 8191 induces phosphorylation and activation of STAT1 and STAT2. RO 8191 inhibits hepatitis C (HCV) cell culture-produced infectious particles and HCV subgenomic replicon (IC50 values 0.20 μM and 0.17 μM, respectively) and inhibits hepatitis B virus replication in cell cultures (IC50 = 0.1 μM). In an animal model RO 8191 inhibits prion invasion and prolongs survival; it also reverses the inhibitory effect of integrin β6 (ITGB6) on the JAK/STAT3 signaling and the epithelial-to-mesenchymal transition pathway and inhibits the proliferation, invasion, and migration of cervical cancer cells. Orally bioavailable.

Technical Data for RO 8191

M. Wt 373.22
Formula C14H5F6N5O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 691868-88-9
PubChem ID 2768133
InChI Key GRHYZVJEXKTJOS-UHFFFAOYSA-N
Smiles FC(F)(C1=CC(C(F)(F)F)=C2C=CC3=NC(C4=NN=CO4)=CN3C2=N1)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RO 8191

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 1.87 5

Preparing Stock Solutions for RO 8191

The following data is based on the product molecular weight 373.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 53.59 mL 267.94 mL 535.88 mL
0.25 mM 10.72 mL 53.59 mL 107.18 mL
0.5 mM 5.36 mL 26.79 mL 53.59 mL
2.5 mM 1.07 mL 5.36 mL 10.72 mL

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References for RO 8191

References are publications that support the biological activity of the product.

Konishi et al (2012) An orally available, small-molecule interferon inhibits viral replication. Sci.Rep. 2 PMID: 22355771

Zheng et al (2021) Silencing of ITGB6 inhibits the progression of cervical carcinoma via regulating JAK/STAT3 signaling pathway. Ann.Transl.Med. 9 PMID: 34268416

Furutani et al (2019) An interferon-like small chemical compound CDM-3008 suppresses hepatitis B virus through induction of interferon-stimulated genes. PLoS One 14 PMID: 31188831

Ishibashi et al (2019) Type I interferon protects neurons from prions in in vivo models. Brain 142 PMID: 30753318


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Keywords: RO 8191, RO 8191 supplier, RO8191, IFNAR2, receptor, agonist, phosphorylates, IFNalpha, interferon, alpha, IFN-alpha, Cytokine, Receptors, Hepatitis, Viruses, 7375, Tocris Bioscience

Citations for RO 8191

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