Ro 51

Pricing Availability   Qty
Description: Potent P2X3 and P2X2/3 antagonist
Chemical Name: 2-[[4-Amino-5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinyl]amino]-1,3-propanediol
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)

Biological Activity for Ro 51

Ro 51 is a potent, dual P2X3 and P2X2/3 antagonist (IC50 values are 2 and 5 nM for rP2X3 and hP2X2/3 respectively). Selective for P2X3 and P2X2/3 over other P2X receptors (IC50 values are > 10 μM for P2X1, P2X2, P2X4, P2X5, and P2X7). Cell permeable.

Technical Data for Ro 51

M. Wt 474.29
Formula C17H23IN4O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1050670-85-3
PubChem ID 24883277
Smiles NC1=NC(NC(CO)CO)=NC=C1OC2=C(C(C)C)C=C(OC)C(I)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ro 51

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 47.43 100
ethanol 47.43 100

Preparing Stock Solutions for Ro 51

The following data is based on the product molecular weight 474.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.11 mL 10.54 mL 21.08 mL
5 mM 0.42 mL 2.11 mL 4.22 mL
10 mM 0.21 mL 1.05 mL 2.11 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Product Datasheets for Ro 51

Certificate of Analysis / Product Datasheet
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References for Ro 51

References are publications that support the biological activity of the product.

Jahangir et al (2009) Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X3/P2X2/3 antagonist for the treatment of pain. Bioorg.Med.Chem.Lett. 19 1632 PMID: 19231178

Syed and Kennedy (2012) Pharmacology of P2X receptors WIREs.Membr.Transp.Signal. 1 16

If you know of a relevant reference for Ro 51, please let us know.

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Keywords: Ro 51, Ro 51 supplier, Ro51, Potent, selective, P2X3, P2X2/3, P2X, purinergic, receptors, antagonists, purinoceptors, Receptors, 4391, Tocris Bioscience

1 Citation for Ro 51

Citations are publications that use Tocris products. Selected citations for Ro 51 include:

Lu et al (2019) Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons. Nat.Commun. 10 1029 PMID: 30833673

Do you know of a great paper that uses Ro 51 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.