Ro 48-8071 fumarate
2,3-Oxidosqualene cyclase (OSC) inhibitor (IC50 = 6.5 nM); blocks cholesterol synthesis in HepG2 cells. Reduces viability of breast cancer cell lines. Also inhibits Ebola virus (EBOV) cell entry (IC50 = 1.74 μM).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||11.29||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 564.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.77 mL||8.86 mL||17.72 mL|
|5 mM||0.35 mL||1.77 mL||3.54 mL|
|10 mM||0.18 mL||0.89 mL||1.77 mL|
|50 mM||0.04 mL||0.18 mL||0.35 mL|
References are publications that support the biological activity of the product.
Morand et al (1997) Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin. J.Lipid.Res. 38 373 PMID: 9162756
Grinter et al (2011) An inverse docking approach for identifying new potential anti-cancer targets. J.Mol.Graph Model. 29 795 PMID: 21315634
Shoemaker et al (2013) Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection. PLoS One. 8 e56265 PMID: 23441171
If you know of a relevant reference for Ro 48-8071 fumarate, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Ro 48-8071 fumarate, Ro 48-8071 fumarate supplier, Ro48-8071, fumarate, 2,3-Oxidosqualene, OSC, inhibitors, inhibits, cholesterol, synthesis, Ebola, virus, EBOV, Other, Isomerases, Antivirals, Lipid, Metabolism, 5389, Tocris Bioscience
Citations for Ro 48-8071 fumarate
Citations are publications that use Tocris products.
Currently there are no citations for Ro 48-8071 fumarate. Do you know of a great paper that uses Ro 48-8071 fumarate from Tocris? Please let us know.
Reviews for Ro 48-8071 fumarate
There are currently no reviews for this product. Be the first to review Ro 48-8071 fumarate and earn rewards!
Have you used Ro 48-8071 fumarate?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide (Spring/Summer 2018)
Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Cell Metabolism
- Fluorescent Imaging
- Signal Transduction
- Stem Cells