Ro 48-8071 fumarate

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Cat.No. 5389 - Ro 48-8071 fumarate | C23H27BrFNO2.C4H4O4 | CAS No. 189197-69-1
Description: 2,3-Oxidosqualene cyclase (OSC) inhibitor; blocks cholesterol synthesis
Chemical Name: (4-Bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]methanone
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

2,3-Oxidosqualene cyclase (OSC) inhibitor (IC50 = 6.5 nM); blocks cholesterol synthesis in HepG2 cells. Reduces viability of breast cancer cell lines. Also inhibits Ebola virus (EBOV) cell entry (IC50 = 1.74 μM).

Compound Libraries

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Technical Data

M. Wt 564.44
Formula C23H27BrFNO2.C4H4O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 189197-69-1
PubChem ID 9959583
InChI Key XCYAYLWZCRGKDS-WLHGVMLRSA-N
Smiles FC1=C(C(C2=CC=C(Br)C=C2)=O)C=CC(OCCCCCCN(C)CC=C)=C1.OC(/C=C/C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 56.44 100
water 11.29 20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 564.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.77 mL 8.86 mL 17.72 mL
5 mM 0.35 mL 1.77 mL 3.54 mL
10 mM 0.18 mL 0.89 mL 1.77 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Morand et al (1997) Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin. J.Lipid.Res. 38 373 PMID: 9162756

Grinter et al (2011) An inverse docking approach for identifying new potential anti-cancer targets. J.Mol.Graph Model. 29 795 PMID: 21315634

Shoemaker et al (2013) Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection. PLoS One. 8 e56265 PMID: 23441171


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Citations for Ro 48-8071 fumarate

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