Ro 48-8071 fumarate

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Description: 2,3-Oxidosqualene cyclase (OSC) inhibitor; blocks cholesterol synthesis
Chemical Name: (4-Bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]methanone
Purity: ≥99% (HPLC)

Biological Activity for Ro 48-8071 fumarate

Ro 48-8071 fumarate is a 2,3-Oxidosqualene cyclase (OSC) inhibitor (IC50 = 6.5 nM); blocks cholesterol synthesis in HepG2 cells. Reduces viability of breast cancer cell lines. Also inhibits Ebola virus (EBOV) cell entry (IC50 = 1.74 μM).

Compound Libraries for Ro 48-8071 fumarate

Ro 48-8071 fumarate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Ro 48-8071 fumarate

M. Wt 564.44
Formula C23H27BrFNO2.C4H4O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 189197-69-1
PubChem ID 9959583
Smiles FC1=C(C(C2=CC=C(Br)C=C2)=O)C=CC(OCCCCCCN(C)CC=C)=C1.OC(/C=C/C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ro 48-8071 fumarate

Solvent Max Conc. mg/mL Max Conc. mM
water 11.29 20 with gentle warming
DMSO 56.44 100

Preparing Stock Solutions for Ro 48-8071 fumarate

The following data is based on the product molecular weight 564.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.77 mL 8.86 mL 17.72 mL
5 mM 0.35 mL 1.77 mL 3.54 mL
10 mM 0.18 mL 0.89 mL 1.77 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

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Product Datasheets for Ro 48-8071 fumarate

References for Ro 48-8071 fumarate

References are publications that support the biological activity of the product.

Morand et al (1997) Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to SimV.. J.Lipid.Res. 38 373 PMID: 9162756

Grinter et al (2011) An inverse docking approach for identifying new potential anti-cancer targets. J.Mol.Graph Model. 29 795 PMID: 21315634

Shoemaker et al (2013) Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection. PLoS One. 8 e56265 PMID: 23441171

If you know of a relevant reference for Ro 48-8071 fumarate, please let us know.

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Citations for Ro 48-8071 fumarate

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