You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Ro 48-8071 fumarate
Biological Activity for Ro 48-8071 fumarate
Ro 48-8071 fumarate is a 2,3-Oxidosqualene cyclase (OSC) inhibitor (IC50 = 6.5 nM); blocks cholesterol synthesis in HepG2 cells. Reduces viability of breast cancer cell lines. Also inhibits Ebola virus (EBOV) cell entry (IC50 = 1.74 μM).
Compound Libraries for Ro 48-8071 fumarate
Technical Data for Ro 48-8071 fumarate
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ro 48-8071 fumarate
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||11.29||20 with gentle warming|
Preparing Stock Solutions for Ro 48-8071 fumarate
The following data is based on the product molecular weight 564.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.77 mL||8.86 mL||17.72 mL|
|5 mM||0.35 mL||1.77 mL||3.54 mL|
|10 mM||0.18 mL||0.89 mL||1.77 mL|
|50 mM||0.04 mL||0.18 mL||0.35 mL|
Product Datasheets for Ro 48-8071 fumarate
References for Ro 48-8071 fumarate
References are publications that support the biological activity of the product.
Morand et al (1997) Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to SimV.. J.Lipid.Res. 38 373 PMID: 9162756
Grinter et al (2011) An inverse docking approach for identifying new potential anti-cancer targets. J.Mol.Graph Model. 29 795 PMID: 21315634
Shoemaker et al (2013) Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection. PLoS One. 8 e56265 PMID: 23441171
If you know of a relevant reference for Ro 48-8071 fumarate, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Ro 48-8071 fumarate, Ro 48-8071 fumarate supplier, Ro48-8071, fumarate, 2,3-Oxidosqualene, OSC, inhibitors, inhibits, cholesterol, synthesis, Ebola, virus, EBOV, Other, Isomerases, Lipid, Metabolism, Antivirals, 5389, Tocris Bioscience
Citations for Ro 48-8071 fumarate
Citations are publications that use Tocris products.
Currently there are no citations for Ro 48-8071 fumarate. Do you know of a great paper that uses Ro 48-8071 fumarate from Tocris? Please let us know.
Reviews for Ro 48-8071 fumarate
There are currently no reviews for this product. Be the first to review Ro 48-8071 fumarate and earn rewards!
Have you used Ro 48-8071 fumarate?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image