RO-3

Pricing Availability Delivery Time Qty
Cat.No. 3052 - RO-3 | C16H22N4O2 | CAS No. 1026582-88-6
Description: Selective P2X3 and P2X2/3 antagonist
Chemical Name: 5-[[4,5-Dimethoxy-2-(methylethyl)phenyl]methyl]-2,4-pyrimidinediamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective homomeric P2X3 and heteromeric P2X2/3 receptor antagonist (pIC50 values are 7.0 and 5.9 respectively) that exhibits no activity at P2X1, P2X2, P2X4, P2X5 and P2X7 receptors (IC50 > 10 μM). Attenuates nociceptive sensitivity in animal models of pain. Orally active and brain penetrant.

Compound Libraries

RO-3 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 302.37
Formula C16H22N4O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1026582-88-6
PubChem ID 11289644
InChI Key PYNPWUIBJMVRIG-UHFFFAOYSA-N
Smiles NC1=NC(N)=NC=C1CC2=C(C(C)C)C=C(OC)C(OC)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.24 100

Preparing Stock Solutions

The following data is based on the product molecular weight 302.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.31 mL 16.54 mL 33.07 mL
5 mM 0.66 mL 3.31 mL 6.61 mL
10 mM 0.33 mL 1.65 mL 3.31 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Ford et al (2006) Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br.J.Pharmacol. 147 S132 PMID: 16465177

Donnelly-Roberts et al (2008) Painful purinergic receptors. J.Pharmacol.Exp.Ther. 324 409 PMID: 18042830

Gever et al (2006) Pharmacology of P2X channels. Eur.J.Physiol. 452 513 PMID:


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Keywords: RO-3, supplier, Selective, P2X2, P2X2/3, antagonists, Receptors, Purinergic, purinoceptors, P2X, Receptors, Tocris Bioscience

Citations for RO-3

Citations are publications that use Tocris products.

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Literature in this Area

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Pathways for RO-3

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