Ro 0437626

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Cat.No. 2188 - Ro 0437626 | C27H35N5O4S | CAS No. 134362-79-1
Description: Selective P2X1 antagonist
Chemical Name: N-[(1R)-2-[[(1S,2R,3S)-1-(Cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]amino]-2-oxo-1-(4-thiazolylmethyl)ethyl]-1H-benzimidazole-2-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective P2X1 purinergic receptor antagonist (IC50 = 3 μM) that displays > 30-fold selectivity over P2X2, P2X3 and P2X2/3 receptors (IC50 > 100 μM).

Technical Data

M. Wt 525.66
Formula C27H35N5O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 134362-79-1
PubChem ID 11663667
InChI Key JHRSGCIIDRWHCD-UARRHKHWSA-N
Smiles O[C@@H](C1CC1)[C@H](O)[C@H](CC2CCCCC2)NC([C@@H](CC3=CSC=N3)NC(C(N4)=NC5=C4C=CC=C5)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 52.57 100
ethanol 52.57 100

Preparing Stock Solutions

The following data is based on the product molecular weight 525.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.9 mL 9.51 mL 19.02 mL
5 mM 0.38 mL 1.9 mL 3.8 mL
10 mM 0.19 mL 0.95 mL 1.9 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Jaime-Figueroa et al (2005) Discovery and synthesis of a novel and selective drug-like P2X1 antagonist. Bioorg.Med.Chem.Lett. 15 3292 PMID: 15927468

King et al (2004) Investigation of the effects of P2 purinoceptor ligands on the micturition reflex in female urethane-anaesthetized rats. Br.J.Pharmacol. 142 519 PMID: 15148261

Ford et al (2006) Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br.J.Pharmacol. 147 S132 PMID: 16465177


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Keywords: Ro 0437626, supplier, Selective, P2X1, antagonists, P2X, Receptors, Purinergic, purinoceptors, Ro0437626, P2X, Receptors, P2X, Receptors, Tocris Bioscience

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