Ro 04-6790

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Cat.No. 2911 - Ro 04-6790 | C12H16N6O2S | CAS No. 202466-68-0
Description: Potent and selective 5-HT6 antagonist
Chemical Name: 4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-benzenesulfonamide
Purity: ≥98% (HPLC)

Biological Activity

Potent and selective 5-HT6 receptor antagonist (pKi values are 7.26 and 7.35 at rat and human 5-HT6 receptors respectively). Displays no affinity at a range of other receptors (IC50 > 10 μM). Induces stretching behavior in rats in vivo.

Technical Data

M. Wt 308.36
Formula C12H16N6O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 202466-68-0
PubChem ID 5312145
Smiles NC1=CC=C(S(NC2=NC(NC)=NC(NC)=C2)(=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 30.84 100

Preparing Stock Solutions

The following data is based on the product molecular weight 308.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.24 mL 16.21 mL 32.43 mL
5 mM 0.65 mL 3.24 mL 6.49 mL
10 mM 0.32 mL 1.62 mL 3.24 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Sleight et al (1998) Characterization of Ro 04-6790 and Ro 63-2563: potent and selective antagonists at human and rat 5-HT6 receptors. Br.J.Pharmacol. 124 556 PMID: 9647481

Bentley et al (1999) Investigation of stretching behaviour induced by the selective 5-HT6 receptor antagonist, Ro 04-6790, in rats. Br.J.Pharmacol. 126 1537 PMID: 10323584

Fone (2008) An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function. Neuropharmacology 55 1015 PMID: 18655798

If you know of a relevant reference for Ro 04-6790, please let us know.

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Keywords: Potent selective 5-HT6 antagonists Serotonin Receptors 5-Hydroxytryptamine Ro04-6790 5-HT6 Receptors

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