Ro 04-6790

Discontinued Product

Ro 04-6790 (Cat. No. 2911) has been withdrawn from sale for commercial reasons.
Description: Potent and selective 5-HT6 antagonist
Chemical Name: 4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-benzenesulfonamide
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for Ro 04-6790

Ro 04-6790 is a potent and selective 5-HT6 receptor antagonist (pKi values are 7.26 and 7.35 at rat and human 5-HT6 receptors respectively). Displays no affinity at a range of other receptors (IC50 > 10 μM). Induces stretching behavior in rats in vivo.

Technical Data for Ro 04-6790

M. Wt 308.36
Formula C12H16N6O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 202466-68-0
PubChem ID 5312145
Smiles NC1=CC=C(S(NC2=NC(NC)=NC(NC)=C2)(=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Ro 04-6790

Certificate of Analysis / Product Datasheet
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References for Ro 04-6790

References are publications that support the biological activity of the product.

Sleight et al (1998) Characterization of Ro 04-6790 and Ro 63-2563: potent and selective antagonists at human and rat 5-HT6 receptors. Br.J.Pharmacol. 124 556 PMID: 9647481

Bentley et al (1999) Investigation of stretching behaviour induced by the selective 5-HT6 receptor antagonist, Ro 04-6790, in rats. Br.J.Pharmacol. 126 1537 PMID: 10323584

Fone (2008) An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function. Neuropharmacology 55 1015 PMID: 18655798

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Keywords: Ro 04-6790, Ro 04-6790 supplier, Potent, selective, 5-HT6, antagonists, Serotonin, Receptors, 5-Hydroxytryptamine, Ro04-6790, 2911, Tocris Bioscience

Citations for Ro 04-6790

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Currently there are no citations for Ro 04-6790.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

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