Ro 04-6790

Pricing Availability Delivery Time Qty
Cat.No. 2911 - Ro 04-6790 | C12H16N6O2S | CAS No. 202466-68-0
Description: Potent and selective 5-HT6 antagonist
Chemical Name: 4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-benzenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective 5-HT6 receptor antagonist (pKi values are 7.26 and 7.35 at rat and human 5-HT6 receptors respectively). Displays no affinity at a range of other receptors (IC50 > 10 μM). Induces stretching behavior in rats in vivo.

Technical Data

M. Wt 308.36
Formula C12H16N6O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 202466-68-0
PubChem ID 5312145
InChI Key JELFWSXQTXRMAJ-UHFFFAOYSA-N
Smiles NC1=CC=C(S(NC2=NC(NC)=NC(NC)=C2)(=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.84 100

Preparing Stock Solutions

The following data is based on the product molecular weight 308.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.24 mL 16.21 mL 32.43 mL
5 mM 0.65 mL 3.24 mL 6.49 mL
10 mM 0.32 mL 1.62 mL 3.24 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Sleight et al (1998) Characterization of Ro 04-6790 and Ro 63-2563: potent and selective antagonists at human and rat 5-HT6 receptors. Br.J.Pharmacol. 124 556 PMID: 9647481

Bentley et al (1999) Investigation of stretching behaviour induced by the selective 5-HT6 receptor antagonist, Ro 04-6790, in rats. Br.J.Pharmacol. 126 1537 PMID: 10323584

Fone (2008) An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function. Neuropharmacology 55 1015 PMID: 18655798


If you know of a relevant reference for Ro 04-6790, please let us know.

View Related Products by Target

View Related Products by Product Action

View all 5-HT6 Receptor Antagonists

Keywords: Ro 04-6790, supplier, Potent, selective, 5-HT6, antagonists, Serotonin, Receptors, 5-Hydroxytryptamine, Ro04-6790, 5-HT6, Receptors, 5-HT6, Receptors, Tocris Bioscience

Citations for Ro 04-6790

Citations are publications that use Tocris products.

Currently there are no citations for Ro 04-6790. Do you know of a great paper that uses Ro 04-6790 from Tocris? If so please let us know.

Ro 04-6790 Reviews

Average Rating:

(Based on 0 Reviews)


1 Star
0%
2 Star
0%
3 Star
0%
4 Star
0%
5 Star
0%

Have you used Ro 04-6790?

Submit a review and receive a $25US/€18/£15/$25CAN Amazon gift card if you include an image -$10US/€7/£6/$10CAN Amazon gift card for reviews without an image. Limited to verified customers in USA, Canada and Europe.


Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Alzheimer's

Alzheimer's Poster

Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.