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Description: Selective TRPV4 agonist
Chemical Name: 1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine
Purity: ≥98% (HPLC)
Biological Activity
Selective TRPV4 agonist (EC50 values are 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively). Displays selectivity over other TRP channels (EC50 values are 0.77, >30, >30 and >100 μM for TRPV4, TRPM8, TRPV3 and TRPV1 receptors respectively). Also antagonizes TRPM8 at relevant concentrations (IC50 = 4 μM).
Compound Libraries
RN 1747 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 395.87 |
| Formula | C17H18ClN3O4S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1024448-59-6 |
| PubChem ID | 5068295 |
| InChI Key | ZNLVYSJQUMALEO-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(S(N2CCN(CC3=CC=CC=C3)CC2)(=O)=O)C([N+]([O-])=O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.59 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 395.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.53 mL | 12.63 mL | 25.26 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.05 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.53 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
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References
References are publications that support the biological activity of the product.
Vincent et al (2009) Identification and characterization of novel TRPV4 modulators. Biochem.Biophys.Res.Comms. 389 490
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Keywords: RN 1747, RN 1747 supplier, RN1747, selective, TRPV4, agonists, transient, receptors, potential, channels, vanilloid, TRPV, 3745, Tocris Bioscience
3 Citations for RN 1747
Citations are publications that use Tocris products. Selected citations for RN 1747 include:
Vizin et al (2015) TRPV4 activates autonomic and behavioural warmth-defence responses in Wistar rats. Acta Physiol 214 275 PMID: 25739906
Shabir et al (2013) Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. World J Gastroenterol 305 F396 PMID: 23720349
Shi et al (2015) Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. Am J Physiol Renal Physiol 21 4852 PMID: 25944998
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Literature in this Area
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Pain Research Product GuideUpdated
A collection of over 280 products for pain research, the guide includes research tools for the study of:
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- G-Protein-Coupled Receptors
- Intracellular Signaling
Pain Poster
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.