RJR 2429 dihydrochloride

Discontinued Product

RJR 2429 dihydrochloride (Cat. No. 1271) has been withdrawn from sale for commercial reasons.
Description: nAChR agonist; displays selectivity for α4β2, α1βγδ and α3β4 subtypes
Chemical Name: (±)-2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane dihydrochloride
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for RJR 2429 dihydrochloride

RJR 2429 dihydrochloride is a potent nAChR agonist that displays selectivity for α4β2 (Ki = 1 nM) and α1βγδ subtypes (EC50 values are 297 and 55 nM respectively). Induces dopamine release from striatal neurons (EC50 = 2 nM) and inhibits ion flux in thalamic neurons (IC50 = 154 nM). Also putative α3β4 agonist that potentiates catecholamine release.

Technical Data for RJR 2429 dihydrochloride

M. Wt 261.19
Formula C12H16N2.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1021418-53-0
PubChem ID 56972204
Smiles C1(C2N3CCC(CC3)C2)=CC=CN=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for RJR 2429 dihydrochloride

Certificate of Analysis / Product Datasheet
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Keywords: RJR 2429 dihydrochloride, RJR 2429 dihydrochloride supplier, Nicotinic, receptor, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, RJR2429, dihydrochloride, (Non-selective), 1271, Tocris Bioscience

Citations for RJR 2429 dihydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.