RJR 2403 oxalate

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Cat.No. 1053 - RJR 2403 oxalate | C10H14N2.C2H2O4 | CAS No. 220662-95-3
Description: α4β2 selective nicotinic agonist
Alternative Names: Metanicotine, TC-2403
Chemical Name: (E)-N-Methyl-4-(3-pyridinyl)-3-buten-1-amine oxalate
Purity: ≥99% (HPLC)
Datasheet
Citations (6)
Literature

Biological Activity

A neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki values are 26 and 36000 nM for α4β2 and α7 receptors respectively). Active in vivo.

Technical Data

M. Wt 252.27
Formula C10H14N2.C2H2O4
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 220662-95-3
PubChem ID 23298272
InChI Key WTIZFOAIQXMQHC-DPZBITMOSA-N
Smiles O=C(O)C(O)=O.CNCC/C=C/C1=CC=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 25.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 252.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.96 mL 19.82 mL 39.64 mL
5 mM 0.79 mL 3.96 mL 7.93 mL
10 mM 0.4 mL 1.98 mL 3.96 mL
50 mM 0.08 mL 0.4 mL 0.79 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bencherif et al (1996) RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization. J.Pharmacol.Exp.Ther. 279 1413 PMID: 8968366

Damaj et al (1999) Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist. J.Pharmacol.Exp.Ther. 291 390 PMID: 10490929

Lippiello et al (1996) RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization. J.Pharmacol.Exp.Ther. 279 1422 PMID: 8968367


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View Related Products by Product Action

View all Nicotinic (α4β2) Receptor Agonists

Keywords: RJR 2403 oxalate, supplier, α4β2, selective, nicotinic, agonists, a4b2, Nicotinic, Receptors, Acetylcholine, nAChR, RJR2403, oxalate, Metanicotine, TC-2403, Nicotinic, (a4b2), Receptors, Nicotinic, (a4b2), Receptors, Tocris Bioscience

6 Citations for RJR 2403 oxalate

Citations are publications that use Tocris products. Selected citations for RJR 2403 oxalate include:

Zhong et al (2013) Nicotine elicits prolonged calcium signaling along ventral hippocampal axons. Dev Neurobiol 8 e82719 PMID: 24349346

Zakharova et al (2011) Chronic cerebral ischaemia forms new cholinergic mechanisms of learning and memory. Int J Alzheimers Dis 2010 954589 PMID: 21197444

Scholze et al (2011) α4β2 nicotinic acetylcholine receptors in the early postnatal mouse superior cervical ganglion. Cardiovasc Res 71 390 PMID: 21485013

Liu et al (2009) A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides. J Neurosci 29 918 PMID: 19176801

Li et al (2009) Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses. Neurosci Lett 462 20 PMID: 19573576

Kiss et al (2014) Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle. PLoS One 9 e109538 PMID: 25303328


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