RJR 2403 oxalate

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Description: Selective α4β2 nAChR agonist
Alternative Names: Metanicotine,TC-2403
Chemical Name: (E)-N-Methyl-4-(3-pyridinyl)-3-buten-1-amine oxalate
Purity: ≥99% (HPLC)
Datasheet
Citations (6)
Reviews
Literature (2)

Biological Activity for RJR 2403 oxalate

RJR 2403 oxalate is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki values are 26 and 36000 nM for α4β2 and α7 receptors respectively). Active in vivo.

Technical Data for RJR 2403 oxalate

M. Wt 252.27
Formula C10H14N2.C2H2O4
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 220662-95-3
PubChem ID 23298272
InChI Key WTIZFOAIQXMQHC-DPZBITMOSA-N
Smiles O=C(O)C(O)=O.CNCC/C=C/C1=CC=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RJR 2403 oxalate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 25.23 100

Preparing Stock Solutions for RJR 2403 oxalate

The following data is based on the product molecular weight 252.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.96 mL 19.82 mL 39.64 mL
5 mM 0.79 mL 3.96 mL 7.93 mL
10 mM 0.4 mL 1.98 mL 3.96 mL
50 mM 0.08 mL 0.4 mL 0.79 mL

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Product Datasheets for RJR 2403 oxalate

Certificate of Analysis / Product Datasheet
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References for RJR 2403 oxalate

References are publications that support the biological activity of the product.

Bencherif et al (1996) RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization. J.Pharmacol.Exp.Ther. 279 1413 PMID: 8968366

Damaj et al (1999) Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist. J.Pharmacol.Exp.Ther. 291 390 PMID: 10490929

Lippiello et al (1996) RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization. J.Pharmacol.Exp.Ther. 279 1422 PMID: 8968367


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View Related Products by Product Action

View all Nicotinic (α4β2) Receptor Agonists

Keywords: RJR 2403 oxalate, RJR 2403 oxalate supplier, α4β2, selective, nicotinic, agonists, a4b2, Nicotinic, Receptors, Acetylcholine, nAChR, RJR2403, oxalate, Metanicotine, TC-2403, (a4b2), 1053, Tocris Bioscience

6 Citations for RJR 2403 oxalate

Citations are publications that use Tocris products. Selected citations for RJR 2403 oxalate include:

Scholze et al (2011) α4β2 nicotinic acetylcholine receptors in the early postnatal mouse superior cervical ganglion. Cardiovasc Res 71 390 PMID: 21485013

Zhong et al (2013) Nicotine elicits prolonged calcium signaling along ventral hippocampal axons. Dev Neurobiol 8 e82719 PMID: 24349346

Zakharova et al (2011) Chronic cerebral ischaemia forms new cholinergic mechanisms of learning and memory. Int J Alzheimers Dis 2010 954589 PMID: 21197444

Kiss et al (2014) Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle. PLoS One 9 e109538 PMID: 25303328


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.