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RJR 2403 oxalate
Biological Activity for RJR 2403 oxalate
RJR 2403 oxalate is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki values are 26 and 36000 nM for α4β2 and α7 receptors respectively). Active in vivo.
Technical Data for RJR 2403 oxalate
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for RJR 2403 oxalate
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for RJR 2403 oxalate
The following data is based on the product molecular weight 252.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.96 mL||19.82 mL||39.64 mL|
|5 mM||0.79 mL||3.96 mL||7.93 mL|
|10 mM||0.4 mL||1.98 mL||3.96 mL|
|50 mM||0.08 mL||0.4 mL||0.79 mL|
Product Datasheets for RJR 2403 oxalate
References for RJR 2403 oxalate
References are publications that support the biological activity of the product.
Bencherif et al (1996) RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization. J.Pharmacol.Exp.Ther. 279 1413 PMID: 8968366
Damaj et al (1999) Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist. J.Pharmacol.Exp.Ther. 291 390 PMID: 10490929
Lippiello et al (1996) RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization. J.Pharmacol.Exp.Ther. 279 1422 PMID: 8968367
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Keywords: RJR 2403 oxalate, RJR 2403 oxalate supplier, α4β2, selective, nicotinic, agonists, a4b2, Nicotinic, Receptors, Acetylcholine, nAChR, RJR2403, oxalate, Metanicotine, TC-2403, (a4b2), 1053, Tocris Bioscience
6 Citations for RJR 2403 oxalate
Citations are publications that use Tocris products. Selected citations for RJR 2403 oxalate include:
Liu et al (2009) A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides. J Neurosci 29 918 PMID: 19176801
Li et al (2009) Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses. Neurosci Lett 462 20 PMID: 19573576
Kiss et al (2014) Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle. PLoS One 9 e109538 PMID: 25303328
Zhong et al (2013) Nicotine elicits prolonged calcium signaling along ventral hippocampal axons. Dev Neurobiol 8 e82719 PMID: 24349346
Zakharova et al (2011) Chronic cerebral ischaemia forms new cholinergic mechanisms of learning and memory. Int J Alzheimers Dis 2010 954589 PMID: 21197444
Scholze et al (2011) α4β2 nicotinic acetylcholine receptors in the early postnatal mouse superior cervical ganglion. Cardiovasc Res 71 390 PMID: 21485013
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.