Reparixin L-lysine salt

Pricing Availability   Qty
Description: Potent CXCR1 and CXCR2 allosteric antagonist
Alternative Names: Repertaxin L-lysine salt
Chemical Name:R)-α-Methyl-4-(2-methylpropyl)-N-(methylsulfonyl)benzeneacetamide L-Lysine salt
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for Reparixin L-lysine salt

Reparixin L-lysine salt is a potent and noncompetitive CXCR1 and CXCR2 allosteric antagonist (IC50 = 1 nM for inhibition of CXCL8-induced human polymorphonuclear cell migration). Also inhibits migration of rodent neutrophils induced by CXCL1, CXCL2, CXCL8 and CINC-1. Inhibits vascular permeability and neutrophil recruitment in in vivo models of mild and severe ischemia/reperfusion injury. Also selectively depletes cancer stem cells in human breast cancer cell lines and xenograft models.

Technical Data for Reparixin L-lysine salt

M. Wt 429.58
Formula C14H21NO3S.C6H14N2O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 266359-93-7
PubChem ID 9932389
Smiles NCCCC[C@H](N)C(O)=O.CC(C)CC1=CC=C(C=C1)[C@@H](C)C(=O)N[S](C)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Reparixin L-lysine salt

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 21.48 50
water 2.15 5 with gentle warming

Preparing Stock Solutions for Reparixin L-lysine salt

The following data is based on the product molecular weight 429.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.66 mL 23.28 mL 46.56 mL
2.5 mM 0.93 mL 4.66 mL 9.31 mL
5 mM 0.47 mL 2.33 mL 4.66 mL
25 mM 0.09 mL 0.47 mL 0.93 mL

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Product Datasheets for Reparixin L-lysine salt

References for Reparixin L-lysine salt

References are publications that support the biological activity of the product.

Bertini et al (2004) Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury. Proc.Natl.Acad.Sci.U.S.A. 101 11791 PMID: 15282370

Souza et al (2004) Repertaxin, a novel inhibitor of rat CXCR2 function, inhibits inflammatory responses that follow intestinal ischaemia and reperfusion injury. Br.J.Pharmacol. 143 132 PMID: 15302676

Ginestier et al (2010) CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. J.Clin.Invest. 120 485 PMID: 20051626

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Citations for Reparixin L-lysine salt

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