Remacemide hydrochloride

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Cat.No. 1622 - Remacemide hydrochloride | C17H20N2O.HCl | CAS No. 111686-79-4
Description: NMDA antagonist; blocks ion channel and allosteric modulatory site
Alternative Names: FPL 12924AA
Chemical Name: 2-Amino-N-(1-methyl-1,2-diphenylethyl)acetamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Non-competitive NMDA receptor antagonist; blocks ion channel and allosteric modulatory site (IC50 = 8 - 68 mM). Anticonvulsant in vivo and metabolizes to a more potent desglycine analog. Weakly blocks voltage-dependent Na+ channels (IC50 = 161 mM).

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M. Wt 304.82
Formula C17H20N2O.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 111686-79-4
PubChem ID 60510
InChI Key HYQMIUSWZXGTCC-UHFFFAOYSA-N
Smiles Cl.CC(CC1=CC=CC=C1)(NC(=O)CN)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 30.48 100
phosphate buffered saline 15.24 50

Preparing Stock Solutions

The following data is based on the product molecular weight 304.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.28 mL 16.4 mL 32.81 mL
5 mM 0.66 mL 3.28 mL 6.56 mL
10 mM 0.33 mL 1.64 mL 3.28 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Palmer et al (1995) Neuroprotective properties of the uncompetitive NMDA receptor antagonist remacemide hydrochloride. Ann.N.Y.Acad.Sci. 765 236 PMID: 7486610

Santangeli et al (2002) Na+ channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes. Eur.J.Pharmacol. 438 63 PMID: 11906711

Subramaniam et al (1996) Block of the N-methyl-D-aspartate receptor by remacemide and its des-glycine metabolite. J.Pharmacol.Exp.Ther. 276 161 PMID: 8558426


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Keywords: NMDA antagonists blocks ion channel allosteric modulatory site Glutamate Receptors N-Methyl-D-Aspartate iGluR Ionotropic AstraZeneca FPL 12924AA NMDA Receptors

Citations for Remacemide hydrochloride

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