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Rec 15/2615 dihydrochloride is a selective α1B-adrenoceptor antagonist (Ki values are 0.3, 1.9 and 2.6 nM at human α1B, α1A and α1D receptors respectively).
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Testa et al (1997) Pharmacological characterization of the uroselective alpha-1 antagonist Rec 15/2739 (SB 216469): Role of the alpha-1L adrenoceptor in tissue selectivity, part II. J.Pharmacol.Exp.Ther. 281 1284 PMID: 9190864
Bremner et al (2000) Ligand design for α1 adrenoceptor subtype selective antagonist. Bioorg.Med.Chem. 8 201 PMID: 10968279
Morston et al (2007) α1A-adrenoceptors mediate contractions to phenylephrine in rabbit penile arteries. Br.J.Pharmacol. 150 112 PMID: 17115072
Keywords: Rec 15/2615 dihydrochloride, Rec 15/2615 dihydrochloride supplier, Selective, α1B-adrenoceptor, alpha1B-adrenoceptor, a1b-adrenoceptor, antagonists, α1b-adrenergic, alpha1b-adrenergic, a1b-adrenergic, Receptors, Rec15/2615, dihydrochloride, Adrenergic, Alpha-1, 3284, Tocris Bioscience
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.