Rec 15/2615 dihydrochloride

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Cat.No. 3284 - Rec 15/2615 dihydrochloride | C26H33N5O5.2HCl | CAS No. 173059-17-1
Description: Selective α1B antagonist
Chemical Name: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[[2-methoxy-6-(1-methylethyl)phenoxy]acetyl]piperazine dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective α1B-adrenoceptor antagonist (Ki values are 0.3, 1.9 and 2.6 nM at human α1B, α1A and α1D receptors respectively).

Compound Libraries

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Technical Data

M. Wt 568.49
Formula C26H33N5O5.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 173059-17-1
PubChem ID 56972225
InChI Key XZGSTPYGKYGQLD-UHFFFAOYSA-N
Smiles NC2=NC(N3CCN(C(COC4=C(OC)C=CC=C4C(C)C)=O)CC3)=NC1=CC(OC)=C(OC)C=C12.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 56.85 100

Preparing Stock Solutions

The following data is based on the product molecular weight 568.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.76 mL 8.8 mL 17.59 mL
5 mM 0.35 mL 1.76 mL 3.52 mL
10 mM 0.18 mL 0.88 mL 1.76 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

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References

References are publications that support the biological activity of the product.

Testa et al (1997) Pharmacological characterization of the uroselective alpha-1 antagonist Rec 15/2739 (SB 216469): Role of the alpha-1L adrenoceptor in tissue selectivity, part II. J.Pharmacol.Exp.Ther. 281 1284 PMID: 9190864

Bremner et al (2000) Ligand design for α1 adrenoceptor subtype selective antagonist. Bioorg.Med.Chem. 8 201 PMID: 10968279

Morston et al (2007) α1A-adrenoceptors mediate contractions to phenylephrine in rabbit penile arteries. Br.J.Pharmacol. 150 112 PMID: 17115072


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Citations for Rec 15/2615 dihydrochloride

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