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Submit ReviewRamipril
Description: Non-peptide, competitive angiotensin-converting enzyme (ACE) inhibitor
Chemical Name: (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid
Purity: ≥99% (HPLC)
Biological Activity for Ramipril
Ramipril is a non-peptide, competitive angiotensin converting enzyme (ACE) inhibitor (IC50 = 5 nM). Prodrug which is hydrolyzed in vivo to the active metabolite ramiprilat. Displays protective effects on endothelium against high-glucose induced dysfunction. Exhibits antihypertensive effects.
Compound Libraries for Ramipril
Ramipril is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Ramipril
| M. Wt | 416.51 |
| Formula | C23H32N2O5 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 87333-19-5 |
| PubChem ID | 5362129 |
| InChI Key | HDACQVRGBOVJII-JBDAPHQKSA-N |
| Smiles | [H][C@@]12CCC[C@@]([H])1N(C([C@H](C)N[C@H]([C@@](OCC)=O)CCC3=CC=CC=C3)=O)[C@H]([C@@](O)=O)C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ramipril
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.65 | 100 | |
| ethanol | 41.65 | 100 |
Preparing Stock Solutions for Ramipril
The following data is based on the product molecular weight 416.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.4 mL | 12 mL | 24.01 mL |
| 5 mM | 0.48 mL | 2.4 mL | 4.8 mL |
| 10 mM | 0.24 mL | 1.2 mL | 2.4 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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Product Datasheets for Ramipril
References for Ramipril
References are publications that support the biological activity of the product.
Tian et al (2014) Ramipril protects the endothelium from high glucose-induced dysfunction through CaMKK beta /AMPK and heme oxygenase-1 activation. J.Pharmacol.Exp.Ther. 350 5 PMID: 24741076
Levitt et al (2006) Human physiologically based pharmacokinetic model for ACE inhibitors: ram. and ramiprilat. BMC Clin. Pharmacol. 6 1 PMID: 16398929
Stevens et al (1988) Ramipril inhibition of rabbit (Oryctolagus cuniculus) small intestinal brush border membrane angiotensin converting enzyme. Comp.Biochem.Physiol C. 91 493 PMID: 2905962
If you know of a relevant reference for Ramipril, please let us know.
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Keywords: Ramipril, Ramipril supplier, Non-peptide, competitive, angiotensin, converting, enzyme, ACE, inhibitors, inhibits, antihypertensive, Angiotensin-Converting, Enzyme, 5250, Tocris Bioscience
Citations for Ramipril
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Literature in this Area
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Cardiovascular Research Product Guide
A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:
- Hypertension
- Thrombosis and Hemostasis
- Atherosclerosis
- Myocardial Infarction
- Ischemia/Reperfusion Injury
- Arrhythmias
- Heart Failure