Pricing Availability Delivery Time Qty
Cat.No. 5250 - Ramipril | C23H32N2O5 | CAS No. 87333-19-5
Description: Non-peptide, competitive angiotensin-converting enzyme (ACE) inhibitor
Chemical Name: (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid
Purity: ≥99% (HPLC)

Biological Activity

Non-peptide, competitive angiotensin converting enzyme (ACE) inhibitor (IC50 = 5 nM). Prodrug which is hydrolyzed in vivo to the active metabolite ramiprilat. Displays protective effects on endothelium against high-glucose induced dysfunction. Exhibits antihypertensive effects.

Compound Libraries

Ramipril is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 416.51
Formula C23H32N2O5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 87333-19-5
PubChem ID 5362129
Smiles [H][C@@]12CCC[C@@]([H])1N(C([C@H](C)N[C@H]([C@@](OCC)=O)CCC3=CC=CC=C3)=O)[C@H]([C@@](O)=O)C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 41.65 100
ethanol 41.65 100

Preparing Stock Solutions

The following data is based on the product molecular weight 416.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.4 mL 12 mL 24.01 mL
5 mM 0.48 mL 2.4 mL 4.8 mL
10 mM 0.24 mL 1.2 mL 2.4 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Tian et al (2014) Ramipril protects the endothelium from high glucose-induced dysfunction through CaMKK beta /AMPK and heme oxygenase-1 activation. J.Pharmacol.Exp.Ther. 350 5 PMID: 24741076

Levitt et al (2006) Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat. BMC Clin. Pharmacol. 6 1 PMID: 16398929

Stevens et al (1988) Ramipril inhibition of rabbit (Oryctolagus cuniculus) small intestinal brush border membrane angiotensin converting enzyme. Comp.Biochem.Physiol C. 91 493 PMID: 2905962

If you know of a relevant reference for Ramipril, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Angiotensin-Converting Enzyme Inhibitors

Keywords: Non-peptide competitive angiotensin converting enzyme ACE inhibitors inhibits antihypertensive Angiotensin-Converting Enzyme

Citations for Ramipril

Citations are publications that use Tocris products.

Currently there are no citations for Ramipril. Do you know of a great paper that uses Ramipril from Tocris? If so please let us know.

Commented out for usability testing


TODO: Add Reviews

Literature in this Area


Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure

Pathways for Ramipril


TODO: Add Protocols