Ramipril

Pricing Availability Delivery Time Qty
Cat.No. 5250 - Ramipril | C23H32N2O5 | CAS No. 87333-19-5
Description: Non-peptide, competitive angiotensin-converting enzyme (ACE) inhibitor
Chemical Name: (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Non-peptide, competitive angiotensin converting enzyme (ACE) inhibitor (IC50 = 5 nM). Prodrug which is hydrolyzed in vivo to the active metabolite ramiprilat. Displays protective effects on endothelium against high-glucose induced dysfunction. Exhibits antihypertensive effects.

Compound Libraries

Ramipril is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 416.51
Formula C23H32N2O5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 87333-19-5
PubChem ID 5362129
InChI Key HDACQVRGBOVJII-JBDAPHQKSA-N
Smiles [H][C@@]12CCC[C@@]([H])1N(C([C@H](C)N[C@H]([C@@](OCC)=O)CCC3=CC=CC=C3)=O)[C@H]([C@@](O)=O)C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.65 100
ethanol 41.65 100

Preparing Stock Solutions

The following data is based on the product molecular weight 416.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.4 mL 12 mL 24.01 mL
5 mM 0.48 mL 2.4 mL 4.8 mL
10 mM 0.24 mL 1.2 mL 2.4 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Tian et al (2014) Ramipril protects the endothelium from high glucose-induced dysfunction through CaMKK beta /AMPK and heme oxygenase-1 activation. J.Pharmacol.Exp.Ther. 350 5 PMID: 24741076

Levitt et al (2006) Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat. BMC Clin. Pharmacol. 6 1 PMID: 16398929

Stevens et al (1988) Ramipril inhibition of rabbit (Oryctolagus cuniculus) small intestinal brush border membrane angiotensin converting enzyme. Comp.Biochem.Physiol C. 91 493 PMID: 2905962


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Citations for Ramipril

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Literature in this Area

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Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure