Pricing Availability   Qty
Description: Non-peptide, competitive angiotensin-converting enzyme (ACE) inhibitor
Chemical Name: (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid
Purity: ≥99% (HPLC)

Biological Activity for Ramipril

Ramipril is a non-peptide, competitive angiotensin converting enzyme (ACE) inhibitor (IC50 = 5 nM). Prodrug which is hydrolyzed in vivo to the active metabolite ramiprilat. Displays protective effects on endothelium against high-glucose induced dysfunction. Exhibits antihypertensive effects.

Compound Libraries for Ramipril

Ramipril is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Ramipril

M. Wt 416.51
Formula C23H32N2O5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 87333-19-5
PubChem ID 5362129
Smiles [H][C@@]12CCC[C@@]([H])1N(C([C@H](C)N[C@H]([C@@](OCC)=O)CCC3=CC=CC=C3)=O)[C@H]([C@@](O)=O)C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ramipril

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 41.65 100
ethanol 41.65 100

Preparing Stock Solutions for Ramipril

The following data is based on the product molecular weight 416.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.4 mL 12 mL 24.01 mL
5 mM 0.48 mL 2.4 mL 4.8 mL
10 mM 0.24 mL 1.2 mL 2.4 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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References for Ramipril

References are publications that support the biological activity of the product.

Tian et al (2014) Ramipril protects the endothelium from high glucose-induced dysfunction through CaMKK beta /AMPK and heme oxygenase-1 activation. J.Pharmacol.Exp.Ther. 350 5 PMID: 24741076

Levitt et al (2006) Human physiologically based pharmacokinetic model for ACE inhibitors: ram. and ramiprilat. BMC Clin. Pharmacol. 6 1 PMID: 16398929

Stevens et al (1988) Ramipril inhibition of rabbit (Oryctolagus cuniculus) small intestinal brush border membrane angiotensin converting enzyme. Comp.Biochem.Physiol C. 91 493 PMID: 2905962

If you know of a relevant reference for Ramipril, please let us know.

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Keywords: Ramipril, Ramipril supplier, Non-peptide, competitive, angiotensin, converting, enzyme, ACE, inhibitors, inhibits, antihypertensive, Angiotensin-Converting, Enzyme, 5250, Tocris Bioscience

Citations for Ramipril

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