Pricing Availability   Qty
Description: Potent and selective D2 and D3 antagonist
Chemical Name: 3,5-Dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide
Purity: ≥98% (HPLC)
Citations (12)
Reviews (1)
Literature (2)

Biological Activity for Raclopride

Raclopride is a selective and potent dopamine D2/D3 receptor antagonist (Ki values are 1.8, 3.5, 2400 and 18000 nM for D2, D3, D4 and D1 receptors respectively). Centrally active following systemic administration in vivo.

Compound Libraries for Raclopride

Raclopride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Raclopride

M. Wt 347.24
Formula C15H20Cl2N2O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 84225-95-6
PubChem ID 3033769
Smiles ClC1=C(OC)C(C(NC[C@H]2N(CC)CCC2)=O)=C(O)C(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Raclopride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 34.72 100
ethanol 8.68 25

Preparing Stock Solutions for Raclopride

The following data is based on the product molecular weight 347.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.88 mL 14.4 mL 28.8 mL
5 mM 0.58 mL 2.88 mL 5.76 mL
10 mM 0.29 mL 1.44 mL 2.88 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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Product Datasheets for Raclopride

Certificate of Analysis / Product Datasheet
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References for Raclopride

References are publications that support the biological activity of the product.

Hall et al (1989) Animal pharmacology of raclopride, a selective DA D2 antagonist. Psychopharmacol.Ser. 7 123 PMID: 2687851

Ogren et al (1986) The selective DA D2 receptor antagonist raclopride discriminates between DA-mediated motor functions. Psychopharmacology 90 287 PMID: 2947255

Seeman and Van Tol (1994) DA receptor pharmacology. TiPS 15 264 PMID: 7940991

If you know of a relevant reference for Raclopride, please let us know.

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Keywords: Raclopride, Raclopride supplier, Potent, selective, D2/D3, antagonists, Dopamine, D2-like, Non-Selective, Receptors, dopaminergic, Non-selective, 1810, Tocris Bioscience

12 Citations for Raclopride

Citations are publications that use Tocris products. Selected citations for Raclopride include:

Ogata et al (2012) DA and full-field illumination activate D1 and D2-D5-type receptors in adult rat retinal ganglion cells. J Comp Neurol 520 4032 PMID: 22678972

Guo (2017) DA D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice. Aging Cell 16 1323 PMID: 28975698

Verharen et al (2019) Differential contributions of striatal dopamine D1 and D2 receptors to component processes of value-based decision making. Neuropsychopharmacology 44 2195 PMID: 31254972

Lassus et al (2018) Glutamatergic and dopaminergic modulation of cortico-striatal circuits probed by dynamic calcium imaging of networks reconstructed in microfluidic chips. Sci Rep 8 17461 PMID: 30498197

Do you know of a great paper that uses Raclopride from Tocris? Please let us know.

Reviews for Raclopride

Average Rating: 5 (Based on 1 Review.)

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Works as intended.
By Anonymous on 05/14/2019
Assay Type: In Vivo
Species: Mouse

Used at a range of doses to block dopamine D2 receptors in vivo to test effect on alcohol-cue learning and seeking behavior. Drug performed well and although didn't impact place preference it did have a clear effect in that it dose-dependently decrease locomotor activity.

PMID: 24005528
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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.