Raclopride

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Cat.No. 1810 - Raclopride | C15H20Cl2N2O3 | CAS No. 84225-95-6
Description: Potent and selective D2 and D3 antagonist
Chemical Name: 3,5-Dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide
Purity: ≥99% (HPLC)
Datasheet
Citations (12)
Reviews (1)
Literature (5)

Biological Activity for Raclopride

Raclopride is a selective and potent dopamine D2/D3 receptor antagonist (Ki values are 1.8, 3.5, 2400 and 18000 nM for D2, D3, D4 and D1 receptors respectively). Centrally active following systemic administration in vivo.

Compound Libraries for Raclopride

Raclopride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Raclopride

M. Wt 347.24
Formula C15H20Cl2N2O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 84225-95-6
PubChem ID 3033769
InChI Key WAOQONBSWFLFPE-VIFPVBQESA-N
Smiles ClC1=C(OC)C(C(NC[C@H]2N(CC)CCC2)=O)=C(O)C(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Raclopride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.72 100
ethanol 8.68 25

Preparing Stock Solutions for Raclopride

The following data is based on the product molecular weight 347.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.88 mL 14.4 mL 28.8 mL
5 mM 0.58 mL 2.88 mL 5.76 mL
10 mM 0.29 mL 1.44 mL 2.88 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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Product Datasheets for Raclopride

Certificate of Analysis / Product Datasheet
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References for Raclopride

References are publications that support the biological activity of the product.

Hall et al (1989) Animal pharmacology of raclopride, a selective DA D2 antagonist. Psychopharmacol.Ser. 7 123 PMID: 2687851

Ogren et al (1986) The selective DA D2 receptor antagonist raclopride discriminates between DA-mediated motor functions. Psychopharmacology 90 287 PMID: 2947255

Seeman and Van Tol (1994) DA receptor pharmacology. TiPS 15 264 PMID: 7940991


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Keywords: Raclopride, Raclopride supplier, Potent, selective, D2/D3, antagonists, Dopamine, D2-like, Non-Selective, Receptors, dopaminergic, Non-selective, 1810, Tocris Bioscience

12 Citations for Raclopride

Citations are publications that use Tocris products. Selected citations for Raclopride include:

Jiang et al (2015) SKF83959 produces antidepressant effects in a chronic social defeat stress model of depression through BDNF-TrkB pathway. Psychopharmacology (Berl) 18 PMID: 25522427

Heath et al (2015) Motivational assessment of mice using the touchscreen operant testing system: effects of DArgic drugs. Psychopharmacology (Berl) 232 4043 PMID: 26156636

Lassus et al (2018) Glutamatergic and dopaminergic modulation of cortico-striatal circuits probed by dynamic calcium imaging of networks reconstructed in microfluidic chips. Sci Rep 8 17461 PMID: 30498197

Ogata et al (2012) DA and full-field illumination activate D1 and D2-D5-type receptors in adult rat retinal ganglion cells. J Comp Neurol 520 4032 PMID: 22678972


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Reviews for Raclopride

Average Rating: 5 (Based on 1 Review.)

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Works as intended.
By Anonymous on 05/14/2019
Assay Type: In Vivo
Species: Mouse

Used at a range of doses to block dopamine D2 receptors in vivo to test effect on alcohol-cue learning and seeking behavior. Drug performed well and although didn't impact place preference it did have a clear effect in that it dose-dependently decrease locomotor activity.

PMID: 24005528
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