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Submit Review(R)-(+)-m-Nitrobiphenyline oxalate
Discontinued Product
(R)-(+)-m-Nitrobiphenyline oxalate (Cat. No. 2948) has been withdrawn from sale for commercial reasons.
Description: Potent α2C agonist
Chemical Name: (R)-2-[1-(3'-Nitrobiphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole oxalate
Purity: ≥99% (HPLC)
Biological Activity for (R)-(+)-m-Nitrobiphenyline oxalate
α2C-adrenoceptor agonist that potently inhibits cAMP accumulation in CHO cells (EC50 = 38 nM). Behaves as an antagonist at α2A and α2B adrenoceptors (pKb values are 7.11 and 6.07 respectively).
Technical Data for (R)-(+)-m-Nitrobiphenyline oxalate
| M. Wt | 401.38 |
| Formula | C17H17N3O3.C2H2O4 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 945618-97-3 |
| Smiles | O=C(O)C(O)=O.[H][C@](C3=NCCN3)(C)OC1=CC=CC=C1C2=CC([N+]([O-])=O)=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (R)-(+)-m-Nitrobiphenyline oxalate
References for (R)-(+)-m-Nitrobiphenyline oxalate
References are publications that support the biological activity of the product.
Crassous et al (2007) α2-adrenoreceptor profile modulation. 3. 1 -(+)-m-Nitrobiphenyline, a new efficient α2C-subtype selective agonist. J.Med.Chem. 50 3964 PMID: 17630725
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Keywords: (R)-(+)-m-Nitrobiphenyline oxalate, (R)-(+)-m-Nitrobiphenyline oxalate supplier, Potent, α2C-adrenoceptor, alpha2C-adrenoceptors, a2c-adrenoceptors, a2c-adrenergic, α2c-adrenergic, alpha2c-adrenergic, agonists, Receptors, Adrenergic, Alpha-2, 2948, Tocris Bioscience
Citations for (R)-(+)-m-Nitrobiphenyline oxalate
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Currently there are no citations for (R)-(+)-m-Nitrobiphenyline oxalate.
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Literature in this Area
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.