(R)-(+)-m-Nitrobiphenyline oxalate

Discontinued Product

Unfortunately (R)-(+)-m-Nitrobiphenyline oxalate (Cat. No. 2948) has been withdrawn from sale for commercial reasons.
Cat.No. 2948 - (R)-(+)-m-Nitrobiphenyline oxalate | C17H17N3O3.C2H2O4 | CAS No. 945618-97-3
Description: Potent α2C agonist
Chemical Name: (R)-2-[1-(3'-Nitrobiphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole oxalate
Purity: ≥99% (HPLC)

Biological Activity

α2C-adrenoceptor agonist that potently inhibits cAMP accumulation in CHO cells (EC50 = 38 nM). Behaves as an antagonist at α2A and α2B adrenoceptors (pKb values are 7.11 and 6.07 respectively).

Technical Data

M. Wt 401.38
Formula C17H17N3O3.C2H2O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 945618-97-3
Smiles O=C(O)C(O)=O.[H][C@](C3=NCCN3)(C)OC1=CC=CC=C1C2=CC([N+]([O-])=O)=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 401.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.49 mL 12.46 mL 24.91 mL
5 mM 0.5 mL 2.49 mL 4.98 mL
10 mM 0.25 mL 1.25 mL 2.49 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Crassous et al (2007) α2-adrenoreceptor profile modulation. 3. 1 -(+)-m-Nitrobiphenyline, a new efficient α2C-subtype selective agonist. J.Med.Chem. 50 3964 PMID: 17630725

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Citations for (R)-(+)-m-Nitrobiphenyline oxalate

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