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Biological Activity for (R)-MG 132
(R)-MG 132 is a potent 20S proteasome inhibitor (IC50 = 0.22 nM). Exhibits cytostatic and cytotoxic effects in tumor cells in vitro.
Technical Data for (R)-MG 132
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (R)-MG 132
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for (R)-MG 132
The following data is based on the product molecular weight 475.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.1 mL||10.51 mL||21.02 mL|
|5 mM||0.42 mL||2.1 mL||4.2 mL|
|10 mM||0.21 mL||1.05 mL||2.1 mL|
|50 mM||0.04 mL||0.21 mL||0.42 mL|
References for (R)-MG 132
References are publications that support the biological activity of the product.
Mroczkiewicz et al (2010) Studies of the synthesis of all stereoisomers of MG-132 proteasome inhibitors in the tumor targeting approach. J.Med.Chem. 53 1509 PMID: 20112914
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Keywords: (R)-MG 132, (R)-MG 132 supplier, (R)-MG132, 20S, proteasome, inhibitors, inhibits, potent, Proteasome, 6033, Tocris Bioscience
3 Citations for (R)-MG 132
Citations are publications that use Tocris products. Selected citations for (R)-MG 132 include:
Armando A et al (2022) Calcineurin Controls Cellular Prion Protein Expression in Mouse Astrocytes. Cells 11 PMID: 35203261
C David et al (2019) Identification of Novel RAS Signaling Therapeutic Vulnerabilities in Diffuse Intrinsic Pontine Gliomas. Cancer Res 79 4026-4041 PMID: 31201162
Eleonora et al (2020) Calcineurin Controls Expression of EAAT1/GLAST in Mouse and Human Cultured Astrocytes through Dynamic Regulation of Protein Synthesis and Degradation. Int J Mol Sci 21 PMID: 32210081
Do you know of a great paper that uses (R)-MG 132 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Targeted Protein Degradation Research Product Guide
This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Ubiquitin-Proteasome System Proteins
- Assays for Protein Degradation
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia