(R)-MG 132

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Cat.No. 6033 - (R)-MG 132 | C26H41N3O5 | CAS No. 1211877-36-9
Description: Potent 20S proteasome inhibitor
Chemical Name: N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-D-leucinamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent 20S proteasome inhibitor (IC50 = 0.22 nM). Exhibits cytostatic and cytotoxic effects in tumor cells in vitro.

Technical Data

M. Wt 475.63
Formula C26H41N3O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1211877-36-9
PubChem ID 45103781
InChI Key TZYWCYJVHRLUCT-ZRBLBEILSA-N
Smiles CC(C[C@@H](C=O)NC([C@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)CC(C)C)=O)CC(C)C)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 9.51 20
DMSO 47.56 100

Preparing Stock Solutions

The following data is based on the product molecular weight 475.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.1 mL 10.51 mL 21.02 mL
5 mM 0.42 mL 2.1 mL 4.2 mL
10 mM 0.21 mL 1.05 mL 2.1 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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References

References are publications that support the biological activity of the product.

Mroczkiewicz et al (2010) Studies of the synthesis of all stereoisomers of MG-132 proteasome inhibitors in the tumor targeting approach. J.Med.Chem. 53 1509 PMID: 20112914


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