Discontinued Product

(R)-(+)-Methanandamide (Cat. No. 1121) has been withdrawn from sale for commercial reasons.
Description: Potent and selective CB1 agonist
Chemical Name: (R)-N-(2-Hydroxy-1-methylethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Purity: ≥98% (HPLC)
Citations (7)
Reviews (1)
Literature (2)

Biological Activity for (R)-(+)-Methanandamide

Stable anandamide analog that is a selective agonist for the CB1 receptor (Ki values are 20 and 815 nM for CB1 and CB2 receptors respectively). Also displays agonist activity at vanilloid receptors.

Water Soluble Emulsion also available.

Technical Data for (R)-(+)-Methanandamide

M. Wt 361.57
Formula C23H39NO2
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 157182-49-5
PubChem ID 6321351

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for (R)-(+)-Methanandamide

Certificate of Analysis / Product Datasheet
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References for (R)-(+)-Methanandamide

References are publications that support the biological activity of the product.

Abadji et al (1994) (R)-Methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability. J.Med.Chem. 37 1889 PMID: 8021930

Carriero et al (1998) A detailed characterization of the effects of four cannabinoid agonists on operant lever pressing. Psychopharmacology (Berl.) 137 147 PMID: 9630001

Khanolkar et al (1996) Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand. J.Med.Chem. 39 4515 PMID: 8893848

Zygmunt et al (1999) Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 400 452 PMID: 10440374

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Keywords: (R)-(+)-Methanandamide, (R)-(+)-Methanandamide supplier, Potent, selective, CB1, agonists, Cannabinoids, Receptors, cb1r, 1121, Tocris Bioscience

7 Citations for (R)-(+)-Methanandamide

Citations are publications that use Tocris products. Selected citations for (R)-(+)-Methanandamide include:

Justinova et al (2008) Blockade of THC-seeking behavior and relapse in monkeys by the cannabinoid CB(1)-receptor antagonist rimon. Neuropsychopharmacology 33 2870 PMID: 18305459

Grace et al (2014) Identification of a pharmacological target for genioglossus reactivation throughout sleep. Nat Chem Biol 37 41 PMID: 24470694

Korossy-Mruk et al (2013) Neonatal DSP-4 treatment modifies antinociceptive effects of the CB1 receptor agonist methanandamide in adult rats. Neurotox Res 23 39 PMID: 22488162

Mendiguren and Pineda (2009) Effect of the CB(1) receptor antagonists rimon. and AM251 on the firing rate of dorsal raphe nucleus neurons in rat brain slices. Br J Pharmacol 158 1579 PMID: 19845674

Reviews for (R)-(+)-Methanandamide

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Low affinity CB1 agonist.
By Jonathan Fay on 05/30/2019
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: COSH-1

Used as an agonist to induce a spectroscopic change of a fluorescent reporter attached to trans-membrane helix six of purified CB1.

PMID: 22846992
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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.