(R)-(+)-HA-966

Pricing Availability Delivery Time Qty
Cat.No. 0281 - (R)-(+)-HA-966 | C4H8N2O2 | CAS No. 123931-04-4
Description: NMDA partial agonist/antagonist; acts at glycine site
Chemical Name: (R)-(+)-3-Amino-1-hydroxypyrrolidin-2-one
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Antagonist/partial agonist at the glycine site of the NMDA receptor; able to cross the blood-brain barrier. Also available as part of the NMDA Receptor - Glycine Site Tocriset™. S-enantiomer (Cat. No. 0282) available.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data

M. Wt 116.12
Formula C4H8N2O2
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 123931-04-4
PubChem ID 6603720
InChI Key HCKUBNLZMKAEIN-GSVOUGTGSA-N
Smiles N[C@@H]1CCN(O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 11.61 100

Preparing Stock Solutions

The following data is based on the product molecular weight 116.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 8.61 mL 43.06 mL 86.12 mL
5 mM 1.72 mL 8.61 mL 17.22 mL
10 mM 0.86 mL 4.31 mL 8.61 mL
50 mM 0.17 mL 0.86 mL 1.72 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Kemp and Priestley (1991) Effects of (+)-HA-966 and 7-chlorokynurenic acid on the kinetics of N-methyl-D-aspartate receptor agonist responses in cat cultured cortical neurons. Mol.Pharmacol. 39 666 PMID: 1674587

Pullan et al (1990) Stereoselectivity for the (R)-enantiomer of HA-966 (1-hydroxy-3-aminopyrrolidone-2) at the glycine site of the N-methyl-D-aspartate receptor complex. J.Neurochem. 55 1346 PMID: 1975835

Pullan et al (1991) Agonist-like character of the (R) enantiomer of 1-hydroxy-3-amino-pyrrolid-2-one (HA-966). Eur.J.Pharmacol. 208 25 PMID: 1834473


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Keywords: (R)-(+)-HA-966, supplier, Partial, NMDA, agonists, antagonists, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, merck, NMDA, Receptors, Tocris Bioscience

1 Citation for (R)-(+)-HA-966

Citations are publications that use Tocris products. Selected citations for (R)-(+)-HA-966 include:

Paquette et al (2008) σ ligands, but not N-methyl-D-aspartate antagonists, reduce levodopa-induced dyskinesias. Elife 19 111 PMID: 18281903


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