Antagonist/partial agonist at the glycine site of the NMDA receptor; able to cross the blood-brain barrier. Also available as part of the NMDA Receptor - Glycine Site Tocriset™. S-enantiomer (Cat. No. 0282) available.
Sold with the permission of Merck Sharp and Dohme Ltd.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 116.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||8.61 mL||43.06 mL||86.12 mL|
|5 mM||1.72 mL||8.61 mL||17.22 mL|
|10 mM||0.86 mL||4.31 mL||8.61 mL|
|50 mM||0.17 mL||0.86 mL||1.72 mL|
References are publications that support the products' biological activity.
Kemp and Priestley (1991) Effects of (+)-HA-966 and 7-chlorokynurenic acid on the kinetics of N-methyl-D-aspartate receptor agonist responses in cat cultured cortical neurons. Mol.Pharmacol. 39 666 PMID: 1674587
Pullan et al (1990) Stereoselectivity for the (R)-enantiomer of HA-966 (1-hydroxy-3-aminopyrrolidone-2) at the glycine site of the N-methyl-D-aspartate receptor complex. J.Neurochem. 55 1346 PMID: 1975835
Pullan et al (1991) Agonist-like character of the (R) enantiomer of 1-hydroxy-3-amino-pyrrolid-2-one (HA-966). Eur.J.Pharmacol. 208 25 PMID: 1834473
If you know of a relevant reference for (R)-(+)-HA-966, please let us know.
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Keywords: (R)-(+)-HA-966, supplier, Partial, NMDA, agonists, antagonists, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, merck, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience
1 Citation for (R)-(+)-HA-966
Citations are publications that use Tocris products. Selected citations for (R)-(+)-HA-966 include:
Paquette et al (2008) σ ligands, but not N-methyl-D-aspartate antagonists, reduce levodopa-induced dyskinesias. Elife 19 111 PMID: 18281903
Do you know of a great paper that uses (R)-(+)-HA-966 from Tocris? If so please let us know.
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