(R)-(+)-HA-966

Pricing Availability   Qty
Description: NMDA partial agonist/antagonist; acts at glycine site
Chemical Name: (R)-(+)-3-Amino-1-hydroxypyrrolidin-2-one
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (6)

Biological Activity for (R)-(+)-HA-966

(R)-(+)-HA-966 is an antagonist/partial agonist at the glycine site of the NMDA receptor; able to cross the blood-brain barrier.

S-enantiomer also available.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data for (R)-(+)-HA-966

M. Wt 116.12
Formula C4H8N2O2
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 123931-04-4
PubChem ID 6603720
InChI Key HCKUBNLZMKAEIN-GSVOUGTGSA-N
Smiles N[C@@H]1CCN(O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (R)-(+)-HA-966

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 11.61 100

Preparing Stock Solutions for (R)-(+)-HA-966

The following data is based on the product molecular weight 116.12. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 8.61 mL 43.06 mL 86.12 mL
5 mM 1.72 mL 8.61 mL 17.22 mL
10 mM 0.86 mL 4.31 mL 8.61 mL
50 mM 0.17 mL 0.86 mL 1.72 mL

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Product Datasheets for (R)-(+)-HA-966

Certificate of Analysis / Product Datasheet
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References for (R)-(+)-HA-966

References are publications that support the biological activity of the product.

Kemp and Priestley (1991) Effects of (+)-HA-966 and 7-chlorokynurenic acid on the kinetics of N-MthD.-aspartate receptor agonist responses in cat cultured cortical neurons. Mol.Pharmacol. 39 666 PMID: 1674587

Pullan et al (1990) Stereoselectivity for the (R)-enantiomer of HA-966 (1-hydroxy-3-aminopyrrolidone-2) at the glycine site of the N-MthD.-aspartate receptor complex. J.Neurochem. 55 1346 PMID: 1975835

Pullan et al (1991) Agonist-like character of the (R) enantiomer of 1-hydroxy-3-amino-pyrrolid-2-one (HA-966). Eur.J.Pharmacol. 208 25 PMID: 1834473


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View Related Products by Target

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Keywords: (R)-(+)-HA-966, (R)-(+)-HA-966 supplier, Partial, NMDA, agonists, antagonists, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, merck, 0281, Tocris Bioscience

1 Citation for (R)-(+)-HA-966

Citations are publications that use Tocris products. Selected citations for (R)-(+)-HA-966 include:

Paquette et al (2008) σ ligands, but not N-MthD.-aspartate antagonists, reduce levodopa-induced dyskinesias. Elife 19 111 PMID: 18281903


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Reviews for (R)-(+)-HA-966

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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