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Discontinued Product(S)-(-)-HA-966 (Cat. No. 0282) has been withdrawn from sale for commercial reasons.
Biological Activity for (S)-(-)-HA-966
(S)-(-)-HA-966 is an possesses potent sedative and ataxic action, probably through disruption of striatal dopaminergic mechanisms.
R-enantiomer also available.
Technical Data for (S)-(-)-HA-966
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for (S)-(-)-HA-966
References are publications that support the biological activity of the product.
Grobaski et al (1997) Responses of rat substantia nigra DA-containing neurones to (-)-HA-966 in vitro. Br.J.Pharmacol. 120 575 PMID: 9051293
Shepard and Lehmann (1992) (±)-1-Hydroxy-3-aminopyrrolidone-2 (HA-966) inhibits the activity of substantia nigra DA neurons through a non-N-MthD.-aspartate receptor mediated mechanism. J.Pharmacol.Exp.Ther. 261 387 PMID: 1578355
Singh et al (1990) Enantiomers of HA-966 (3-amino-1-hydroxypyrrolidin-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-MthD.-aspartate receptor antagonist, but (-)-HA966 is a potent γ-butyrolactone-like sedative. Proc.Natl.Acad.Sci.U.S.A. 87 347 PMID: 2153294
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Keywords: (S)-(-)-HA-966, (S)-(-)-HA-966 supplier, NMDA, antagonists, partial, agonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlu, Ionotropic, 0282, Tocris Bioscience
Citations for (S)-(-)-HA-966
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Currently there are no citations for (S)-(-)-HA-966.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Huntington's Disease Poster
Huntington's disease (HD) is a monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the MSN intracellular signaling pathways implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.