Possesses potent sedative and ataxic action, probably through disruption of striatal dopaminergic mechanisms.
R-enantiomer also available.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 100 mM in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 116.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||8.61 mL||43.06 mL||86.12 mL|
|5 mM||1.72 mL||8.61 mL||17.22 mL|
|10 mM||0.86 mL||4.31 mL||8.61 mL|
|50 mM||0.17 mL||0.86 mL||1.72 mL|
References are publications that support the products' biological activity.
Grobaski et al (1997) Responses of rat substantia nigra dopamine-containing neurones to (-)-HA-966 in vitro. Br.J.Pharmacol. 120 575 PMID: 9051293
Shepard and Lehmann (1992) (±)-1-Hydroxy-3-aminopyrrolidone-2 (HA-966) inhibits the activity of substantia nigra dopamine neurons through a non-N-methyl-D-aspartate receptor mediated mechanism. J.Pharmacol.Exp.Ther. 261 387 PMID: 1578355
Singh et al (1990) Enantiomers of HA-966 (3-amino-1-hydroxypyrrolidin-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA966 is a potent γ-butyrolactone-like sedative. Proc.Natl.Acad.Sci.U.S.A. 87 347 PMID: 2153294
If you know of a relevant reference for (S)-(-)-HA-966, please let us know.
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Keywords: (S)-(-)-HA-966, supplier, NMDA, antagonists, partial, agonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlu, Ionotropic, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience
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