(R)-(-)-α-Methylhistamine dihydrobromide

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Cat.No. 0569 - (R)-(-)-alpha-Methylhistamine dihydrobromide | C6H11N3.2HBr | CAS No. 868698-49-1
Description: Potent, standard H3 agonist
Chemical Name: (R)-(-)-α-Methyl-1H-imidazole-4-ethanamine dihydrobromide
Purity: ≥99% (HPLC)
Citations (4)

Biological Activity

Very potent, high affinity H3 agonist (KD = 50.3 nM) that displays > 200-fold selectivity over H4 receptors. Inhibits H3-mediated histamine synthesis and release in the CNS and stimulates H4-mediated eosinophil shape change (EC50 = 66 nM).

Available as part of the Histamine H3 Receptor Tocriset™. S-enantiomer also available.

Technical Data

M. Wt 287
Formula C6H11N3.2HBr
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 868698-49-1
PubChem ID 45037031
Smiles N[C@H](C)CC1=CNC=N1.Br.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 28.7 100

Preparing Stock Solutions

The following data is based on the product molecular weight 287. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.48 mL 17.42 mL 34.84 mL
5 mM 0.7 mL 3.48 mL 6.97 mL
10 mM 0.35 mL 1.74 mL 3.48 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Buckland et al (2003) Histamine induces cytoskeletal changes in human eosinophils via the H4 receptor. Br.J.Pharmacol. 140 1117 PMID: 14530216

Hew et al (1990) Characterization of histamine-H3 receptors in guinea pig ileum with H3-selective ligands. Br.J.Pharmacol. 101 621 PMID: 1963802

Oishi et al (1989) Effects of histamine H3-agonist (R)-α-methylhistamine and the antagonist thioperamide on histamine modulation in the mouse and rat brain. J.Neurochem. 52 1388 PMID: 2540269

Schwartz et al (1990) A third histamine receptor subtype - characterization, localization and functions of the H3-receptor. Agents Actions 30 13 PMID: 1695431

Shahid et al (2009) Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review. Open Immunol.J. 2 9 PMID:

If you know of a relevant reference for (R)-(-)-α-Methylhistamine dihydrobromide, please let us know.

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Keywords: (R)-(-)-alpha-Methylhistamine dihydrobromide, supplier, Potent, H3, agonists, Receptors, Histamine, histaminergic, (R)-(-)-alpha-Methylhistamine, dihydrobromide, Histamine, H3, Receptors, Histamine, H3, Receptors, Tocris Bioscience

4 Citations for (R)-(-)-α-Methylhistamine dihydrobromide

Citations are publications that use Tocris products. Selected citations for (R)-(-)-α-Methylhistamine dihydrobromide include:

Rapanelli et al (2016) The Histamine H3 Receptor Differentially Modulates Mitogen-activated Protein Kinase (MAPK) and Akt Signaling in Striatonigral and Striatopallidal Neurons. J Biol Chem. 291 21042 PMID: 27510032

Spaethling et al (2014) Serotonergic neuron regulation informed by in vivo single-cell transcriptomics. J Clin Invest 28 771 PMID: 24192459

Kim et al (2013) Effects of histamine on cultured interstitial cells of cajal in murine small intestine. Korean J Physiol Pharmacol 17 149 PMID: 23626477

Holden et al (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. FASEB J 152 891 PMID: 17891168

Do you know of a great paper that uses (R)-(-)-α-Methylhistamine dihydrobromide from Tocris? If so please let us know.

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