Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewR 892
Description: Potent and selective B1 antagonist
Biological Activity
Potent and selective bradykinin B1 receptor antagonist (ID50 values are 2.8 and > 600 nM at B1 and B2 receptors respectively). Exhibits no intrinsic agonist activity and is resistant to aminopeptidase and kininase II (ACE) cleavage. Displays hypertensive activity in vivo.
Technical Data
| M. Wt | 1154.37 |
| Formula | C58H83N13O12 |
| Sequence |
KRPPGFSXI (Modifications: Lys-1 = N-terminal Ac, Phe-6 = (αMe)Phe, X = DβNal) |
| Storage | Desiccate at -20°C |
| CAS Number | 229030-05-1 |
| PubChem ID | 10374059 |
| InChI Key | STDZHNYUPODPLD-DDLDLQAOSA-N |
| Smiles | CC[C@H](C)[C@H](NC(=O)[C@@H](CC1=CC2=CC=CC=C2C=C1)NC(=O)[C@H](CO)NC(=O)[C@](C)(CC1=CC=CC=C1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(C)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solubility | Soluble to 2 mg/ml in water |
Product Datasheets
References
References are publications that support the biological activity of the product.
Gobeil et al (1996) Structure-activity studies of B1 receptor related peptide. Hypertension 28 833 PMID: 8901831
Duka et al (2003) Mechanisms mediating the vasoactive effects of the B1 receptors of bradykinin. Hypertension 42 1021 PMID: 14557281
Gobeil et al (1998) Kinin B1 receptor antagonists containing α-methyl-L-phenylalanine: in vitro and in vivo antagonistic activities. Hypertension 33 823
If you know of a relevant reference for R 892, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: R 892, R 892 supplier, Potent, selective, B1, antagonists, Receptors, Bradykinin, R892, 3226, Tocris Bioscience
1 Citation for R 892
Citations are publications that use Tocris products. Selected citations for R 892 include:
Mattis et al (2014) Frequency-dependent, cell type-divergent signaling in the hippocamposeptal projection. J Neurosci 34 11769 PMID: 25164672
Do you know of a great paper that uses R 892 from Tocris? Please let us know.
Reviews for R 892
There are currently no reviews for this product. Be the first to review R 892 and earn rewards!
Have you used R 892?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GPCR Product Listing
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
- Rhodopsin-like Receptors
- Glutamate Receptors
- Frizzled Receptors
- GPCR Signaling
Pain Research Product GuideUpdated
A collection of over 250 products for pain research, the guide includes research tools for the study of:
- Nociception
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
Peptide Hormone Receptors Product ListingUpdated
A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:
- Anterior Pituitary Regulation
- Blood Pressure Regulation
- Feeding and Appetite Regulation
- Glucose Regulation
- Peptide Hormone Processing
Cardiovascular Poster
Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.