R 892

Pricing Availability Delivery Time Qty
Cat.No. 3226 - R 892 | Ac-Lys-Arg-Pro-Pro-Gly-(αmethyl)Phe-Ser-DβNal-Ile | CAS No. 229030-05-1
Description: Potent and selective B1 antagonist
Datasheet
Citations (1)
Literature

Biological Activity

Potent and selective bradykinin B1 receptor antagonist (ID50 values are 2.8 and > 600 nM at B1 and B2 receptors respectively). Exhibits no intrinsic agonist activity and is resistant to aminopeptidase and kininase II (ACE) cleavage. Displays hypertensive activity in vivo.

Technical Data

M. Wt 1154.37
Formula C58H83N13O12
Sequence KRPPGFSXI

(Modifications: Lys-1 = N-terminal Ac, Phe-6 = (αMe)Phe, X = DβNal)

Storage Desiccate at -20°C
CAS Number 229030-05-1
PubChem ID 10374059
InChI Key STDZHNYUPODPLD-DDLDLQAOSA-N
Smiles CC[C@H](C)[C@H](NC(=O)[C@@H](CC1=CC2=CC=CC=C2C=C1)NC(=O)[C@H](CO)NC(=O)[C@](C)(CC1=CC=CC=C1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(C)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1154.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.87 mL 4.33 mL 8.66 mL
5 mM 0.17 mL 0.87 mL 1.73 mL
10 mM 0.09 mL 0.43 mL 0.87 mL
50 mM 0.02 mL 0.09 mL 0.17 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Gobeil et al (1996) Structure-activity studies of B1 receptor related peptide. Hypertension 28 833 PMID: 8901831

Duka et al (2003) Mechanisms mediating the vasoactive effects of the B1 receptors of bradykinin. Hypertension 42 1021 PMID: 14557281

Gobeil et al (1998) Kinin B1 receptor antagonists containing α-methyl-L-phenylalanine: in vitro and in vivo antagonistic activities. Hypertension 33 823 PMID:


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Keywords: Potent selective B1 antagonists Receptors Bradykinin R892 Bradykinin Receptors

1 Citation for R 892

Citations are publications that use Tocris products. Selected citations for R 892 include:

Mattis et al (2014) Frequency-dependent, cell type-divergent signaling in the hippocamposeptal projection. J Neurosci 34 11769 PMID: 25164672


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