R 892
Biological Activity
Potent and selective bradykinin B1 receptor antagonist (ID50 values are 2.8 and > 600 nM at B1 and B2 receptors respectively). Exhibits no intrinsic agonist activity and is resistant to aminopeptidase and kininase II (ACE) cleavage. Displays hypertensive activity in vivo.
Technical Data
| M. Wt | 1154.37 |
| Formula | C58H83N13O12 |
| Sequence |
KRPPGFSXI (Modifications: Lys-1 = N-terminal Ac, Phe-6 = (αMe)Phe, X = DβNal) |
| Storage | Desiccate at -20°C |
| CAS Number | 229030-05-1 |
| PubChem ID | 10374059 |
| InChI Key | STDZHNYUPODPLD-DDLDLQAOSA-N |
| Smiles | CC[C@H](C)[C@H](NC(=O)[C@@H](CC1=CC2=CC=CC=C2C=C1)NC(=O)[C@H](CO)NC(=O)[C@](C)(CC1=CC=CC=C1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(C)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 2 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1154.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.87 mL | 4.33 mL | 8.66 mL |
| 5 mM | 0.17 mL | 0.87 mL | 1.73 mL |
| 10 mM | 0.09 mL | 0.43 mL | 0.87 mL |
| 50 mM | 0.02 mL | 0.09 mL | 0.17 mL |
Molarity Calculator
Reconstitution Calculator
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Gobeil et al (1996) Structure-activity studies of B1 receptor related peptide. Hypertension 28 833 PMID: 8901831
Duka et al (2003) Mechanisms mediating the vasoactive effects of the B1 receptors of bradykinin. Hypertension 42 1021 PMID: 14557281
Gobeil et al (1998) Kinin B1 receptor antagonists containing α-methyl-L-phenylalanine: in vitro and in vivo antagonistic activities. Hypertension 33 823 PMID:
If you know of a relevant reference for R 892, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Potent selective B1 antagonists Receptors Bradykinin R892 Bradykinin Receptors
1 Citation for R 892
Citations are publications that use Tocris products. Selected citations for R 892 include:
Mattis et al (2014) Frequency-dependent, cell type-divergent signaling in the hippocamposeptal projection. J Neurosci 34 11769 PMID: 25164672
Do you know of a great paper that uses R 892 from Tocris? If so please let us know.
Literature in this Area
GPCR Product Listing
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
- Rhodopsin-like Receptors
- Secretin-like Receptors
- Glutamate Receptors
- Frizzled Receptors
- GPCR Signaling
Pain Research Product Guide
A collection of over 250 products for pain research, the guide includes research tools for the study of:
- Nociception
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
Peptide Hormone Receptors Product Listing
A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:
- Anterior Pituitary Regulation
- Blood Pressure Regulation
- Feeding and Appetite Regulation
- Glucose Regulation
- Peptide Hormone Processing
Cardiovascular Poster
Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.
