R 715

Pricing Availability Delivery Time Qty
Cat.No. 3407 - R 715 | Ac-Lys-Arg-Pro-Pro-Gly-Phe-Ser-DβNal-Ile | CAS No. 185052-09-9
Description: Potent and selective B1 antagonist
Datasheet
Citations (4)
Literature

Biological Activity

Potent and selective bradykinin B1 receptor antagonist (pA2 = 8.49). Displays no activity at B2 receptors. Reduces mechanical hypernociception in a mouse model of neuropathic pain. Metabolically stable.

Technical Data

M. Wt 1140.35
Formula C57H81N13O12
Sequence KRPPGFSXI

(Modifications: Lys-1 = N-terminal Ac, X = DβNal)

Storage Desiccate at -20°C
CAS Number 185052-09-9
PubChem ID 5311397
InChI Key DOSXOGUJJBDRGQ-VUBDHFCFSA-N
Smiles CC[C@H](C)[C@H](NC(=O)[C@@H](CC1=CC2=CC=CC=C2C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(C)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 5 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1140.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.88 mL 4.38 mL 8.77 mL
5 mM 0.18 mL 0.88 mL 1.75 mL
10 mM 0.09 mL 0.44 mL 0.88 mL
50 mM 0.02 mL 0.09 mL 0.18 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Gobeil et al (1996) Structure-activity studies of B1 receptor-related peptides. Hypertension. 28 833 PMID: 8901831

Quintao et al (2008) Neuropathic pain-like behavior after brachial plexus avulsion in mice: the relevance of kinin B1 and B2 receptors. J.Neurosci. 28 2856 PMID: 18337416

Abdouh et al (2008) Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B1 and B2 receptors. Br.J.Pharmacol. 154 136 PMID: 18311190


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Keywords: R 715, supplier, Potent, selective, B1, antagonists, Receptors, Bradykinin, R715, Bradykinin, Receptors, Bradykinin, Receptors, Tocris Bioscience

4 Citations for R 715

Citations are publications that use Tocris products. Selected citations for R 715 include:

Falsetta et al (2016) A role for bradykinin signaling in chronic vulvar pain. The Journal of Pain PMID: 27544818

Kawaguchi et al (2015) Functional expression of bradykinin B1 and B2 receptors in neonatal rat trigeminal ganglion neurons. J Cereb Blood Flow Metab 9 229 PMID: 26124706

Pinheiro et al (2013) Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. Cell Commun Signal 11 70 PMID: 24047499

Albert-Weissenberger et al (2012) Blocking of bradykinin receptor B1 protects from focal closed head injury in mice by reducing axonal damage and astroglia activation. EMBO Mol Med 32 1747 PMID: 22569191


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