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Potent and selective bradykinin B1 receptor antagonist (pA2 = 8.49). Displays no activity at B2 receptors. Reduces mechanical hypernociception in a mouse model of neuropathic pain. Metabolically stable.
(Modifications: Lys-1 = N-terminal Ac, X = DβNal)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 5 mg/ml in water|
References are publications that support the biological activity of the product.
Gobeil et al (1996) Structure-activity studies of B1 receptor-related peptides. Hypertension. 28 833 PMID: 8901831
Quintao et al (2008) Neuropathic pain-like behavior after brachial plexus avulsion in mice: the relevance of kinin B1 and B2 receptors. J.Neurosci. 28 2856 PMID: 18337416
Abdouh et al (2008) Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B1 and B2 receptors. Br.J.Pharmacol. 154 136 PMID: 18311190
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Keywords: R 715, R 715 supplier, Potent, selective, B1, antagonists, Receptors, Bradykinin, R715, 3407, Tocris Bioscience
6 Citations for R 715
Citations are publications that use Tocris products. Selected citations for R 715 include:
Kawaguchi et al (2015) Functional expression of bradykinin B1 and B2 receptors in neonatal rat trigeminal ganglion neurons. J Cereb Blood Flow Metab 9 229 PMID: 26124706
Falsetta et al (2016) A role for bradykinin signaling in chronic vulvar pain. The Journal of Pain PMID: 27544818
Pinheiro et al (2013) Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. Cell Commun Signal 11 70 PMID: 24047499
Brailoiu (2017) Modulation of cardiac vagal tone by bradykinin acting on nucleus ambiguus. Neuroscience 365 23 PMID: 28951324
Xu et al (2014) Nicotine exaggerates LPS-induced airway hyperreactivity via JNK-mediated up-regulation of Toll-like receptor 4. Am J Respir Cell Mol Biol 51 370 PMID: 24669857
Albert-Weissenberger et al (2012) Blocking of bradykinin receptor B1 protects from focal closed head injury in mice by reducing axonal damage and astroglia activation. EMBO Mol Med 32 1747 PMID: 22569191
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