R 1485 dihydrochloride

Discontinued Product

R 1485 dihydrochloride (Cat. No. 4964) has been withdrawn from sale for commercial reasons.
Description: Selective and high affinity 5-HT6 antagonist
Chemical Name: 4-[(2-Fluorophenyl)sulfonyl]-3,4-dihydro-8-(1-piperazinyl)-2H-1,4-benzoxazine dihydrochloride
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for R 1485 dihydrochloride

R 1485 dihydrochloride is a selective and high affinity 5-HT6 antagonist (pKi = 8.9); displays low hERG inhibition. Exhibits >100 fold selectivity against a panel of 50 targets including other 5-HT receptor subtypes. Brain penetrant.

Technical Data for R 1485 dihydrochloride

M. Wt 450.35
Formula C18H20FN3O3S.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 90488993
Smiles FC(C=CC=C4)=C4S(N2CCOC1=C(N3CCNCC3)C=CC=C12)(=O)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for R 1485 dihydrochloride

References for R 1485 dihydrochloride

References are publications that support the biological activity of the product.

Zhao et al (2007) 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT6 receptor antagonists. Bioorg.Med.Chem.Lett. 17 3504 PMID: 17485206

Liu et al (2009) 5-HT6 antagonists as potential treatment for cognitive dysfunction. Drug Des.Rev. 70 145

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Citations for R 1485 dihydrochloride

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Currently there are no citations for R 1485 dihydrochloride.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.