R 1485 dihydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 4964 - R 1485 dihydrochloride | C18H20FN3O3S.2HCl
Description: Selective and high affinity 5-HT6 antagonist
Chemical Name: 4-[(2-Fluorophenyl)sulfonyl]-3,4-dihydro-8-(1-piperazinyl)-2H-1,4-benzoxazine dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective and high affinity 5-HT6 antagonist (pKi = 8.9); displays low hERG inhibition. Exhibits >100 fold selectivity against a panel of 50 targets including other 5-HT receptor subtypes. Brain penetrant.

Compound Libraries

R 1485 dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 450.35
Formula C18H20FN3O3S.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 90488993
InChI Key SNXURKRGPYXWRN-UHFFFAOYSA-N
Smiles FC(C=CC=C4)=C4S(N2CCOC1=C(N3CCNCC3)C=CC=C12)(=O)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.03 100
water 45.03 100

Preparing Stock Solutions

The following data is based on the product molecular weight 450.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.1 mL 22.2 mL
5 mM 0.44 mL 2.22 mL 4.44 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Zhao et al (2007) 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT6 receptor antagonists. Bioorg.Med.Chem.Lett. 17 3504 PMID: 17485206

Liu et al (2009) 5-HT6 antagonists as potential treatment for cognitive dysfunction. Drug Des.Rev. 70 145 PMID:


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Citations for R 1485 dihydrochloride

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Literature in this Area

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Pathways for R 1485 dihydrochloride

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