QX 222

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Cat.No. 1043 - QX 222 | C13H21ClN2O | CAS No. 5369-00-6
Description: Na+ channel blocker
Chemical Name: 2-[(2,6-Dimethylphenyl)amino]-N,N,N-trimethyl-2-oxoethaniminium chloride
Datasheet
Citations (2)
Literature

Biological Activity

Sodium channel blocker.

Technical Data

M. Wt 256.77
Formula C13H21ClN2O
Storage Desiccate at RT
CAS Number 5369-00-6
PubChem ID 9795082
InChI Key WFKXSWWTOZBDME-UHFFFAOYSA-N
Smiles [Cl-].CC1=CC=CC(C)=C1NC(=O)C[N+](C)(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 256.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.89 mL 19.47 mL 38.95 mL
5 mM 0.78 mL 3.89 mL 7.79 mL
10 mM 0.39 mL 1.95 mL 3.89 mL
50 mM 0.08 mL 0.39 mL 0.78 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Cuevas and Adams (1994) Local anaesthetic blockade of neuronal nicotinic ACh receptor-channels in rat parasympathetic ganglion cells. Br.J.Pharmacol. 11 663 PMID: 7517326

Hanck et al (1994) Kinetic effects of quaternary lidocaine block of cardiac sodium channels: a gating current study. J.Gen.Physiol. 103 19 PMID: 8169596


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Keywords: QX 222, supplier, Na+, channel, blockers, Sodium, NaV, Channels, voltage-gated, voltage-dependent, QX222, Voltage-gated, Sodium, Channels, Voltage-gated, Sodium, Channels, Tocris Bioscience

2 Citations for QX 222

Citations are publications that use Tocris products. Selected citations for QX 222 include:

Li et al (2005) Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin. Antimicrob Agents Chemother 49 388 PMID: 15616319

Slesinger (2001) Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels. Biophys J 80 707 PMID: 11159438


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