QX 222

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Cat.No. 1043 - QX 222 | C13H21ClN2O | CAS No. 5369-00-6
Description: Na+ channel blocker
Chemical Name: 2-[(2,6-Dimethylphenyl)amino]-N,N,N-trimethyl-2-oxoethaniminium chloride
Citations (2)
Literature (5)

Biological Activity

Sodium channel blocker.

Technical Data

M. Wt 256.77
Formula C13H21ClN2O
Storage Desiccate at RT
CAS Number 5369-00-6
PubChem ID 9795082
Smiles [Cl-].CC1=CC=CC(C)=C1NC(=O)C[N+](C)(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 100 mM in water


References are publications that support the biological activity of the product.

Cuevas and Adams (1994) Local anaesthetic blockade of neuronal nicotinic ACh receptor-channels in rat parasympathetic ganglion cells. Br.J.Pharmacol. 11 663 PMID: 7517326

Hanck et al (1994) Kinetic effects of quaternary lidocaine block of cardiac sodium channels: a gating current study. J.Gen.Physiol. 103 19 PMID: 8169596

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Keywords: QX 222, QX 222 supplier, Na+, channel, blockers, Sodium, NaV, Channels, voltage-gated, voltage-dependent, QX222, Voltage-gated, 1043, Tocris Bioscience

2 Citations for QX 222

Citations are publications that use Tocris products. Selected citations for QX 222 include:

Slesinger (2001) Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels. Biophys J 80 707 PMID: 11159438

Li et al (2005) Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin. Antimicrob Agents Chemother 49 388 PMID: 15616319

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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