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Sodium channel blocker.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 100 mM in water|
References are publications that support the biological activity of the product.
Cuevas and Adams (1994) Local anaesthetic blockade of neuronal nicotinic ACh receptor-channels in rat parasympathetic ganglion cells. Br.J.Pharmacol. 11 663 PMID: 7517326
Hanck et al (1994) Kinetic effects of quaternary lidocaine block of cardiac sodium channels: a gating current study. J.Gen.Physiol. 103 19 PMID: 8169596
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Keywords: QX 222, QX 222 supplier, Na+, channel, blockers, Sodium, NaV, Channels, voltage-gated, voltage-dependent, QX222, Voltage-gated, 1043, Tocris Bioscience
2 Citations for QX 222
Citations are publications that use Tocris products. Selected citations for QX 222 include:
Slesinger (2001) Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels. Biophys J 80 707 PMID: 11159438
Li et al (2005) Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin. Antimicrob Agents Chemother 49 388 PMID: 15616319
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.