Sodium channel blocker.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 100 mM in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 256.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.89 mL||19.47 mL||38.95 mL|
|5 mM||0.78 mL||3.89 mL||7.79 mL|
|10 mM||0.39 mL||1.95 mL||3.89 mL|
|50 mM||0.08 mL||0.39 mL||0.78 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Cuevas and Adams (1994) Local anaesthetic blockade of neuronal nicotinic ACh receptor-channels in rat parasympathetic ganglion cells. Br.J.Pharmacol. 11 663 PMID: 7517326
Hanck et al (1994) Kinetic effects of quaternary lidocaine block of cardiac sodium channels: a gating current study. J.Gen.Physiol. 103 19 PMID: 8169596
If you know of a relevant reference for QX 222, please let us know.
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Keywords: Na+ channel blockers Sodium NaV Channels voltage-gated voltage-dependent QX222 Voltage-gated Sodium Channels
2 Citations for QX 222
Citations are publications that use Tocris products. Selected citations for QX 222 include:
Li et al (2005) Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin. Antimicrob Agents Chemother 49 388 PMID: 15616319
Slesinger (2001) Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels. Biophys J 80 707 PMID: 11159438
Do you know of a great paper that uses QX 222 from Tocris? If so please let us know.