PZ 3022

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Description: PanK Activator
Chemical Name: 6-[4-[2-(4-Cyclopropylphenyl)acetyl]-1-piperazinyl]-3-pyridazinecarbonitrile
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for PZ 3022

PZ 3022 is a potent allosteric pantothenate kinase (PanK) activator (EC50=5.3 nM for PanK3). In a mouse model of propionic acidemia, treatment with PZ 3022 increases hepatic CoASH and C2-CoA, and decreases C3-CoA, improving intracellular C3:C2-CoA ratio and plasma C3:C2-carnitine ratios. PZ 3022 is orally bioavailable.

Licensing Information

Sold under license from St. Jude Children's Research Hospital

Technical Data for PZ 3022

M. Wt 347.42
Formula C20H21N5O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2170608-85-0
PubChem ID 132261124
InChI Key CXSADKGUEBUMLH-UHFFFAOYSA-N
Smiles N#CC1=NN=C(N2CCN(CC2)C(CC3=CC=C(C4CC4)C=C3)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PZ 3022

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.74 100

Preparing Stock Solutions for PZ 3022

The following data is based on the product molecular weight 347.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.88 mL 14.39 mL 28.78 mL
5 mM 0.58 mL 2.88 mL 5.76 mL
10 mM 0.29 mL 1.44 mL 2.88 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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References for PZ 3022

References are publications that support the biological activity of the product.

Subramanian et al (2021) Pantothenate kinase activation relieves coenzyme A sequestration and improves mitochondrial function in mice with propionic acidemia. Sci.Transl.Med. 13 eabf5965 PMID: 34524863


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Keywords: PZ 3022, PZ 3022 supplier, PZ3022, orally, bioavailable, in, vivo, PZ-3022, hepatic, CoASH, C2-CoA, C3-CoA, C3:C2-CoA, C3:C2-carnitine, carnitine, TCA, cycle, Other, Kinases, 7876, Tocris Bioscience

Citations for PZ 3022

Citations are publications that use Tocris products.

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