Pyroxamide

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Cat.No. 4403 - Pyroxamide | C13H19N3O3 | CAS No. 382180-17-8
Description: Histone deacetylase inhibitor
Chemical Name: N-Hydroxy-N'-3-pyridinyloctanediamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of histone deacetylase (HDAC); potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells.

Compound Libraries

Pyroxamide is also offered as part of the Tocriscreen Plus and Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 265.31
Formula C13H19N3O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 382180-17-8
PubChem ID 4996
InChI Key PTJGLFIIZFVFJV-UHFFFAOYSA-N
Smiles O=C(CCCCCCC(NO)=O)NC1=CC=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.53 100
ethanol 5.31 20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 265.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.77 mL 18.85 mL 37.69 mL
5 mM 0.75 mL 3.77 mL 7.54 mL
10 mM 0.38 mL 1.88 mL 3.77 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Butler et al (2001) Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. Clin.Cancer Res. 7 962 PMID: 11309347

Remiszewski et al (2002) Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J.Med.Chem. 45 755 PMID: 11831887

Bradner et al (2010) Chemical phylogenetics of histone deacetylases. Nat.Chem.Biol. 6 238 PMID: 20139990


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Keywords: Pyroxamide hdac histone deacetylase inhibitors inhibits epigenetics Histone Deacetylases

Citations for Pyroxamide

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Literature in this Area

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Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics

Epigenetics Research Bulletin

Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

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  • Histone Deacetylases
  • Histone Demethylases
  • Histone Methyltransferases
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Pathways for Pyroxamide

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