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Submit ReviewPyroxamide
Discontinued Product
Pyroxamide (Cat. No. 4403) has been withdrawn from sale for commercial reasons.
Description: Histone deacetylase inhibitor
Chemical Name: N-Hydroxy-N'-3-pyridinyloctanediamide
Purity: ≥98% (HPLC)
Biological Activity for Pyroxamide
Pyroxamide is an inhibitor of histone deacetylase (HDAC); potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells.
Technical Data for Pyroxamide
| M. Wt | 265.31 |
| Formula | C13H19N3O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 382180-17-8 |
| PubChem ID | 4996 |
| InChI Key | PTJGLFIIZFVFJV-UHFFFAOYSA-N |
| Smiles | O=C(CCCCCCC(NO)=O)NC1=CC=CN=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Pyroxamide
References for Pyroxamide
References are publications that support the biological activity of the product.
Butler et al (2001) Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. Clin.Cancer Res. 7 962 PMID: 11309347
Remiszewski et al (2002) Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J.Med.Chem. 45 755 PMID: 11831887
Bradner et al (2010) Chemical phylogenetics of histone deacetylases. Nat.Chem.Biol. 6 238 PMID: 20139990
Carrillo et al (2015) Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT). Bioorg.Med.Chem. 23 5151 PMID: 25637120
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Keywords: Pyroxamide, Pyroxamide supplier, Pyroxamide, hdac, histone, deacetylase, inhibitors, inhibits, epigenetics, Class, I, HDACs, 4403, Tocris Bioscience
1 Citation for Pyroxamide
Citations are publications that use Tocris products. Selected citations for Pyroxamide include:
Kim (2018) Suppression of TGFβ-mediated conversion of endothelial cells and fibroblasts into cancer associated (myo)fibroblasts via HDAC inhibition. Br J Cancer 118 1359 PMID: 29695769
Reviews for Pyroxamide
Average Rating: 5 (Based on 1 Review.)
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TGF beta high responder treated with 1.5 μM Pyroxamide (HDAC 1 inhibitor) for 48 h. Cell lysates were analysed by western blot..
By
Anonymous on 11/15/2019
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: C3-TAg tumour cell
TGF beta high responder treated with 1.5 μM Pyroxamide (HDAC 1 inhibitor) for 48 h. Cell lysates were analysed by western blot.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
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