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PU 23 is a multidrug resistance protein (MRP) 4 inhibitor. Sensitizes MRP4-overexpressing cells to the anticancer agent 6-Mercaptopurine (Cat. No. 4103; 6-MP) (IC50 values are 14.11 and 6.06 μM in the absence and presence of compound, respectively). Increases accumulation of 6-MP in MRP4-overexpressing cells.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 425.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.7 mL||23.5 mL||47 mL|
|2.5 mM||0.94 mL||4.7 mL||9.4 mL|
|5 mM||0.47 mL||2.35 mL||4.7 mL|
|25 mM||0.09 mL||0.47 mL||0.94 mL|
References are publications that support the biological activity of the product.
Chen et al (2018) Discovery of novel multidrug resistance protein 4 (MRP4) inhibitors as active agents reducing resistance to anticancer drug 6-Mercaptopurine (6-MP) by structure and ligand-based virtual screening. PLoS One 13 e0205175 PMID: 30321196
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Keywords: PU 23, PU 23 supplier, PU23, multidrug, resistance, protein, 4, MRP4, inhibitor, inhibits, ABCC4, Multidrug, Transporters, 6885, Tocris Bioscience
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There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.