Home / Pharmacology / Transporters / Multidrug Transporters / Multidrug Transporter Inhibitors / PU 23

PU 23

Cat. No. 6885 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Multidrug resistance protein (MRP) 4 inhibitor
Chemical Name: N-[[[4-[[(Phenylmethyl)amino]sulfonyl]phenyl]amino]thioxomethyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for PU 23

PU 23 is a multidrug resistance protein (MRP) 4 inhibitor. Sensitizes MRP4-overexpressing cells to the anticancer agent 6-Mercaptopurine (Cat. No. 4103; 6-MP) (IC50 values are 14.11 and 6.06 μM in the absence and presence of compound, respectively). Increases accumulation of 6-MP in MRP4-overexpressing cells.

Technical Data for PU 23

M. Wt 425.52
Formula C21H19N3O3S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 817635-93-1
PubChem ID 4779049
InChI Key RYIRRFWVFHEXTH-UHFFFAOYSA-N
Smiles O=C(NC(=S)NC1=CC=C(C=C1)[S](=O)(=O)NCC1=CC=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PU 23

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.28 50

Preparing Stock Solutions for PU 23

The following data is based on the product molecular weight 425.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.7 mL 23.5 mL 47 mL
2.5 mM 0.94 mL 4.7 mL 9.4 mL
5 mM 0.47 mL 2.35 mL 4.7 mL
25 mM 0.09 mL 0.47 mL 0.94 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for PU 23

References are publications that support the biological activity of the product.

Chen et al (2018) Discovery of novel multidrug resistance protein 4 (MRP4) inhibitors as active agents reducing resistance to anticancer drug 6-Mercaptopurine (6-MP) by structure and ligand-based virtual screening. PLoS One 13 e0205175 PMID: 30321196

If you know of a relevant reference for PU 23, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Multidrug Transporter Inhibitors

Keywords: PU 23, PU 23 supplier, PU23, multidrug, resistance, protein, 4, MRP4, inhibitor, inhibits, ABCC4, Multidrug, Transporters, 6885, Tocris Bioscience

Citations for PU 23

Citations are publications that use Tocris products.

Currently there are no citations for PU 23. Do you know of a great paper that uses PU 23 from Tocris? Please let us know.

Reviews for PU 23

There are currently no reviews for this product. Be the first to review PU 23 and earn rewards!

Have you used PU 23?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.