PU 23

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Cat.No. 6885 - PU 23 | C21H19N3O3S2 | CAS No. 817635-93-1
Description: Multidrug resistance protein (MRP) 4 inhibitor
Chemical Name: N-[[[4-[[(Phenylmethyl)amino]sulfonyl]phenyl]amino]thioxomethyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity

Multidrug resistance protein (MRP) 4 inhibitor. Sensitizes MRP4-overexpressing cells to the anticancer agent 6-Mercaptopurine (Cat. No. 4103; 6-MP) (IC50 values are 14.11 and 6.06 μM in the absence and presence of compound, respectively). Increases accumulation of 6-MP in MRP4-overexpressing cells.

Technical Data

M. Wt 425.52
Formula C21H19N3O3S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 817635-93-1
PubChem ID 4779049
InChI Key RYIRRFWVFHEXTH-UHFFFAOYSA-N
Smiles O=C(NC(=S)NC1=CC=C(C=C1)[S](=O)(=O)NCC1=CC=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.28 50

Preparing Stock Solutions

The following data is based on the product molecular weight 425.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.7 mL 23.5 mL 47 mL
2.5 mM 0.94 mL 4.7 mL 9.4 mL
5 mM 0.47 mL 2.35 mL 4.7 mL
25 mM 0.09 mL 0.47 mL 0.94 mL

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References

References are publications that support the biological activity of the product.

Chen et al (2018) Discovery of novel multidrug resistance protein 4 (MRP4) inhibitors as active agents reducing resistance to anticancer drug 6-Mercaptopurine (6-MP) by structure and ligand-based virtual screening. PLoS One 13 e0205175 PMID: 30321196


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Keywords: PU 23, PU 23 supplier, PU23, multidrug, resistance, protein, 4, MRP4, inhibitor, inhibits, ABCC4, Multidrug, Transporters, 6885, Tocris Bioscience

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