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Description: Potent MMP-3 expression inhibitor; neuroprotective
Chemical Name: 1-(3,4-Dihydro-7-hydroxy-6-methoxy-2(1H)-isoquinolinyl)-1-propanone
Purity: ≥98% (HPLC)
Biological Activity
Potent inhibitor of MMP-3 expression (IC50 = 60 nM); down-regulates induction of MMP-3 in both stressed dopaminergic cells and activated microglia. Also suppresses proinflammatory responses and inhibits NO production in activated microglia. Attenuates motor deficits, prevents neurodegeneration and suppresses microglial activation in a Parkinson's disease mouse model. Brain penetrant.
Technical Data
| M. Wt | 235.28 |
| Formula | C13H17NO3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1032822-42-6 |
| PubChem ID | 24812799 |
| InChI Key | BEDYMEDICHGLSE-UHFFFAOYSA-N |
| Smiles | O=C(CC)N2CC1=CC(O)=C(OC)C=C1CC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.53 | 100 | |
| 1eq. NaOH | 4.71 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 235.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.25 mL | 21.25 mL | 42.5 mL |
| 5 mM | 0.85 mL | 4.25 mL | 8.5 mL |
| 10 mM | 0.43 mL | 2.13 mL | 4.25 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.85 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Son et al (2012) A novel compound PTIQ protects the nigral DArgic neurones in an animal model of Parkinsons disease induced by MPTP. Br.J.Pharmacol. 165 2213 PMID: 21951056
Seo et al (2008) Syntheses of tetrahydroisoquinoline derivatives that inhibit NO production in activated BV-2 microglial cells. Eur.J.Med.Chem. 43 1160 PMID: 17980460
If you know of a relevant reference for PTIQ, please let us know.
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Literature in this Area
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