PTIQ
Biological Activity
Potent inhibitor of MMP-3 expression (IC50 = 60 nM); down-regulates induction of MMP-3 in both stressed dopaminergic cells and activated microglia. Also suppresses proinflammatory responses and inhibits NO production in activated microglia. Attenuates motor deficits, prevents neurodegeneration and suppresses microglial activation in a Parkinson's disease mouse model. Brain penetrant.
Technical Data
| M. Wt | 235.28 |
| Formula | C13H17NO3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1032822-42-6 |
| PubChem ID | 24812799 |
| InChI Key | BEDYMEDICHGLSE-UHFFFAOYSA-N |
| Smiles | O=C(CC)N2CC1=CC(O)=C(OC)C=C1CC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. NaOH | 4.71 | 20 | |
| DMSO | 23.53 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 235.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.25 mL | 21.25 mL | 42.5 mL |
| 5 mM | 0.85 mL | 4.25 mL | 8.5 mL |
| 10 mM | 0.43 mL | 2.13 mL | 4.25 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.85 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Son et al (2012) A novel compound PTIQ protects the nigral dopaminergic neurones in an animal model of Parkinsons disease induced by MPTP. Br.J.Pharmacol. 165 2213 PMID: 21951056
Seo et al (2008) Syntheses of tetrahydroisoquinoline derivatives that inhibit NO production in activated BV-2 microglial cells. Eur.J.Med.Chem. 43 1160 PMID: 17980460
If you know of a relevant reference for PTIQ, please let us know.
View Related Products by Target
Keywords: potent MMP-3 expression inhibitors neuroprotective dopamingeric dopamine NO nitric oxide neurodegeneration Parkinson's disease blood brain barrier permeable MPTP - inhibits PD brain penetrant Matrix Metalloprotease
Citations for PTIQ
Citations are publications that use Tocris products.
Currently there are no citations for PTIQ. Do you know of a great paper that uses PTIQ from Tocris? If so please let us know.
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