PTIQ

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Cat.No. 4604 - PTIQ | C13H17NO3 | CAS No. 1032822-42-6
Description: Potent MMP-3 expression inhibitor; neuroprotective
Chemical Name: 1-(3,4-Dihydro-7-hydroxy-6-methoxy-2(1H)-isoquinolinyl)-1-propanone
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent inhibitor of MMP-3 expression (IC50 = 60 nM); down-regulates induction of MMP-3 in both stressed dopaminergic cells and activated microglia. Also suppresses proinflammatory responses and inhibits NO production in activated microglia. Attenuates motor deficits, prevents neurodegeneration and suppresses microglial activation in a Parkinson's disease mouse model. Brain penetrant.

Technical Data

M. Wt 235.28
Formula C13H17NO3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1032822-42-6
PubChem ID 24812799
InChI Key BEDYMEDICHGLSE-UHFFFAOYSA-N
Smiles O=C(CC)N2CC1=CC(O)=C(OC)C=C1CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 4.71 20
DMSO 23.53 100

Preparing Stock Solutions

The following data is based on the product molecular weight 235.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.25 mL 21.25 mL 42.5 mL
5 mM 0.85 mL 4.25 mL 8.5 mL
10 mM 0.43 mL 2.13 mL 4.25 mL
50 mM 0.09 mL 0.43 mL 0.85 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Son et al (2012) A novel compound PTIQ protects the nigral dopaminergic neurones in an animal model of Parkinsons disease induced by MPTP. Br.J.Pharmacol. 165 2213 PMID: 21951056

Seo et al (2008) Syntheses of tetrahydroisoquinoline derivatives that inhibit NO production in activated BV-2 microglial cells. Eur.J.Med.Chem. 43 1160 PMID: 17980460


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Keywords: potent MMP-3 expression inhibitors neuroprotective dopamingeric dopamine NO nitric oxide neurodegeneration Parkinson's disease blood brain barrier permeable MPTP - inhibits PD brain penetrant Matrix Metalloprotease

Citations for PTIQ

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Angiogenesis in Cancer

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Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Pathways for PTIQ

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