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Cat.No. 4604 - PTIQ | C13H17NO3 | CAS No. 1032822-42-6
Description: Potent MMP-3 expression inhibitor; neuroprotective
Chemical Name: 1-(3,4-Dihydro-7-hydroxy-6-methoxy-2(1H)-isoquinolinyl)-1-propanone
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity

Potent inhibitor of MMP-3 expression (IC50 = 60 nM); down-regulates induction of MMP-3 in both stressed dopaminergic cells and activated microglia. Also suppresses proinflammatory responses and inhibits NO production in activated microglia. Attenuates motor deficits, prevents neurodegeneration and suppresses microglial activation in a Parkinson's disease mouse model. Brain penetrant.

Technical Data

M. Wt 235.28
Formula C13H17NO3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1032822-42-6
PubChem ID 24812799
Smiles O=C(CC)N2CC1=CC(O)=C(OC)C=C1CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 23.53 100
1eq. NaOH 4.71 20

Preparing Stock Solutions

The following data is based on the product molecular weight 235.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.25 mL 21.25 mL 42.5 mL
5 mM 0.85 mL 4.25 mL 8.5 mL
10 mM 0.43 mL 2.13 mL 4.25 mL
50 mM 0.09 mL 0.43 mL 0.85 mL

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References are publications that support the biological activity of the product.

Son et al (2012) A novel compound PTIQ protects the nigral DArgic neurones in an animal model of Parkinsons disease induced by MPTP. Br.J.Pharmacol. 165 2213 PMID: 21951056

Seo et al (2008) Syntheses of tetrahydroisoquinoline derivatives that inhibit NO production in activated BV-2 microglial cells. Eur.J.Med.Chem. 43 1160 PMID: 17980460

If you know of a relevant reference for PTIQ, please let us know.

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Citations for PTIQ

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