Discontinued Product

PTIQ (Cat. No. 4604) has been withdrawn from sale for commercial reasons.
Description: Potent MMP-3 expression inhibitor; neuroprotective
Chemical Name: 1-(3,4-Dihydro-7-hydroxy-6-methoxy-2(1H)-isoquinolinyl)-1-propanone
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for PTIQ

PTIQ is a potent inhibitor of MMP-3 expression (IC50 = 60 nM); down-regulates induction of MMP-3 in both stressed dopaminergic cells and activated microglia. Also suppresses proinflammatory responses and inhibits NO production in activated microglia. Attenuates motor deficits, prevents neurodegeneration and suppresses microglial activation in a Parkinson's disease mouse model. Brain penetrant.

Technical Data for PTIQ

M. Wt 235.28
Formula C13H17NO3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1032822-42-6
PubChem ID 24812799
Smiles O=C(CC)N2CC1=CC(O)=C(OC)C=C1CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for PTIQ

References are publications that support the biological activity of the product.

Son et al (2012) A novel compound PTIQ protects the nigral DArgic neurones in an animal model of Parkinsons disease induced by MPTP. Br.J.Pharmacol. 165 2213 PMID: 21951056

Seo et al (2008) Syntheses of tetrahydroisoquinoline derivatives that inhibit NO production in activated BV-2 microglial cells. Eur.J.Med.Chem. 43 1160 PMID: 17980460

Keywords: PTIQ, PTIQ supplier, potent, MMP-3, expression, inhibitors, neuroprotective, dopamingeric, dopamine, NO, nitric, oxide, neurodegeneration, Parkinson's, disease, blood, brain, barrier, permeable, MPTP, -, inhibits, PD, penetrant, Matrix, Metalloprotease, Non-selective, NOS, 4604, Tocris Bioscience

Citations for PTIQ

Citations are publications that use Tocris products.

Currently there are no citations for PTIQ.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.